Development of MMP specific 19F-MRS tracer to assess the disruption of neuro vascular unit in brain
| Project/Area Number |
25461310
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HUBER J Vincent 新潟大学, 脳研究所, 准教授 (40422620)
TSUJITA Mika 新潟大学, 脳研究所, 准教授 (60397180)
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| Research Collaborator |
NAKADA Tsutomu
KWEE L Ingrid
ZHANG Bingwen
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経機能画像学 / 磁気共鳴学 / 19F / 脳虚血 / 出血性梗塞 |
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| Outline of Final Research Achievements |
Hemorrhagic transformation (HT) is one of the most severe side effects in clot buster therapy for an acute stage of cerebral infarction. However, there is no objective biomarker to predict HT in a clinical situation at this point. To solve this issue, we developed the new type 19F molecular ligand, TGF-019, that can assess the disruption of neuro vascular unit in the brain. We prooved the sensitivity and specificity of TGF-019 for MMP2, MMP9 and MMP3. Then we utilized it to assess the disruption of neuro vascular unit of ischemic mouse brain. 19F-MR image of TGN-019 administered mouse with acute cerebral infarction showed the high signal intensity in the case with most severe disruption of neuro vascular unit. Beside signal intensity was correlated with total MMP2 and MMP9 activity confirmed with biological test of the specimen.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Multiple therapeutic effects of progranulin on experimental acute ischemic stroke.2015
Author(s)
Kanazawa K, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T
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Journal Title
Brain
Volume: 79
Issue: 7
Pages: 1-17
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy.2014
Author(s)
Natsumeda M, Igarashi H, Nomura T, Ogura R, Tsukamoto Y, Kobayashi T, Aoki H, Okamoto K, Kakita A, Takahashi H, Nakada T, Fujii Y.
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Journal Title
Acta Neuropathol Commun.
Volume: 2
Pages: 158-158
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 高磁場MRSの展望2014
Author(s)
五十嵐 博中
Organizer
第26回日本王循環代謝学会
Place of Presentation
岡山
Year and Date
2014-11-21 – 2014-11-22
Related Report
Invited
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