| Project/Area Number |
25461313
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
Ito Mizuki 名古屋大学, 医学部附属病院, 助教 (50437042)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hirohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)
SOBUE Gen 名古屋大学, 医学系研究科, 特任教授 (20148315)
SENDA Joe 名古屋大学, 医学部附属病院, 医員 (80569781)
ATSUTA Naoki 名古屋大学, 医学部附属病院, 病院講師 (90547457)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 多系統萎縮症（MSA） / VBM / TBSS / 安静時機能MRI / バイオマーカー / 安静時脳機能MRI / 多系統萎縮症 / Mean diffusivity / fractional anisotropy / voxel-based morphometry |
|---|
| Outline of Final Research Achievements |
Although the patients with multiple system atrophy (MSA) had decreased scores of Addenbrooke’s Cognitive Examination Revised (ACE-R), MRI showed atrophy of the cerebellum, not the cerebral cortex. By contrast, the MSA patients with low scores of ACE-R showed broad anatomical impairments of neural circuits in the frontal lobe, especially the superior longitudinal fasciculus, in the analysis using the tract-based spatial statistics technique, compared with those with normal scores of ACE-R and normal controls.
Together, MSA showed the anatomical atrophy of white matter earlier than that of the cerebral cortex. These results suggested a decline of cognitive function in MSA might be associated with these anatomical damages of neural circuits.
|
