| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
We developed high-density surface electrode and its analysis methods for detect a single motor unit potential (SMUP) non-invasively in order to diagnosis for amyotrophic lateral sclerosis (ALS) using commonly-used EMG machine. The amplitude and negative waveform area of the SMUP were significantly higher in ALS patients than in healthy controls. There was no correlation between the size of SMUP and disease duration. Fasciculation potentials were also able to distinguish between voluntary contraction potential at 94% probability. The use of ultrasound is thought to be effective in the non-invasive diagnosis of neuromuscular disease, we also able to confirm that usefulness ultrasound diaphragm thickness, compound muscle action potential amplitude and forced vital capacity were well correlated. High-density surface EMG is non-invasive examination, but it is necessary to use in combination with other non-invasive test such as ultrasound for early diagnosis of ALS.
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