A new therapeutic attempt to target neuronal ionic channels for ALS

Research Project

Project/Area Number	25461316
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurology
Research Institution	The University of Tokushima
Principal Investigator	NODERA Hiroyuki 徳島大学, 大学院医歯薬学研究部, 講師 (40363147)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	筋萎縮性側索硬化症 / イオンチャネル / 神経保護作用 / 筋萎縮側索硬化症
Outline of Final Research Achievements	Neuronal ionic channels have been considered to play a major role in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Medications that influence ionic channels have been administered to SOD1 model mice. There was no significant clinical neuroprotective effect by any of the agent, presumably due to its rapid progression after onset. We developed a new animal model for ALS that has slower onset and progression that mimics human diseases. We continue to test the channel hypothesis with the use of the new animal model.

Report

(4 results)