Novel therapeutic strategy for amyotrophic lateral sclerosis targeting calretinin and monocyte chemoattractant protein-1
| Project/Area Number |
25461317
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
HAYASHI SHINTARO 九州大学, 医学(系)研究科(研究院), 研究員 (90312876)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHYAGI YASUMASA 愛媛大学, 医学系研究科, 教授 (30301336)
TATEISHI TAKAHISA 九州大学, 医学研究院, 共同研究員 (50423546)
KAWAMURA NOBUTOSHI 九州大学, 医学研究院, 共同研究員 (00432930)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 筋萎縮性側索硬化症 / カルレチニン / 単球走化性蛋白質１ / ミクログリア / マクロファージ / TDP-43 / 脊髄前側索 / カルシウム結合蛋白 / 運動ニューロン / 孤発性筋萎縮性側索硬化症 / 樹状細胞 / 単球走化性蛋白1 |
|---|
| Outline of Final Research Achievements |
We examined relationships between massive microglia/macrophage (Mi/MΦ) infiltrations in the anterolateral funiculus of amyotrophic lateral sclerosis (ALS) spinal cord and TDP-43 pathology, calretinin (CR, calcium-binding protein), and CCL2 (monocyte chemoattractant protein-1). The results showed that among the Mi/MΦ with various morphologies, the numbers of Mi/MΦ with foamy appearance had a positive correlation with amount of motor neurons with TDP-43 pathology in ALS patients. It was also revealed morphologically that CCL2, elevated in the patient's cerebrospinal fluid, might be derived from the astrocytes. Although, distributions of Mi/MΦ in ALS spinal cord are similar to those of CR-immunoreactive axons in normal human spinal cord, administration of anti-CR antibodies to ALS mouse model (G93A) or CR peptide to normal rat indicated no pathogenicity of CR.
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
-
-
[Journal Article] Decreased CCR2 and CD62L expression on peripheral blood classical monocytes in amyotrophic lateral sclerosis2014
Author(s)
Yi Wen Cui, Yuji Kawano, Ryo Yamasaki, Nan Shi, Katsuhisa Masaki, Noriko Isobe, Tomomi Yonekawa, Takuya Matsushita, Takahisa Tateishi, Shintaro Hayashi, and Jun-ichi Kira
-
Journal Title
Clinical and Experimental Neuroimmunology
Volume: in press
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
