Considering an objective evaluating system for acute reperfusion therapy utilizing perfusion imaging
| Project/Area Number |
25461320
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyorin University (2014-2016)
Oita University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 灌流画像 / 急性期脳梗塞 / 血行再建療法 / 国際研究者交流 / 虚血性脳血管障害 / 側副血行 / 虚血性ペナンブラ / 豪州 |
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| Outline of Final Research Achievements |
Evidence of therapeutic effect of mechanical thrombectomy (MT) for acute ischemic stroke had not been established at 2013, when this study was designed and started. This study aimed to develop novel system that enables objective evaluation of MT using perfusion imaging (CT perfusion: CTP). In 2015, however, 5 randomized controlled trials revealed positive result and showed solid efficacy of MT in patients within 6 hours of stroke onset. Therefore, this study was forced to modify its original plan. During the study period, feasibility of CTP based imaging strategy was confirmed among the consecutive stroke patients admitted in 2016. The threshold level of cerebral blood flow on CTP was estimated as <40% of contralateral side, though the tracer delay (> 2 sec) needed to be corrected.
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Report
(5 results)
Research Products
(83 results)
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[Journal Article] Design and Rationale of the RELAXED (Recurrent Embolism Lessened by rivaroxaban, an Anti-Xa agent, of Early Dosing for acute ischemic stroke and transient ischemic attack with atrial fibrillation) Study.2016
Author(s)
Yasaka M, Minematsu K, Toyoda K, Yamagami H, Yoshimura S, Nagao T, Mori E, Hirano T, Hamasaki T, Yamaguchi T.
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Journal Title
J Stroke Cerebrovasc Dis
Volume: 25
Issue: 6
Pages: 1342-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Genotypic and phenotypic spectrum of CADASIL in Japan: the experience at a referral center in Kumamoto University from 1997 to 2014.2015
Author(s)
Ueda A., Ueda M., Nagatoshi A., Hirano T., Ito T., Arai N., Uyama E., Mori K., Nakamura M., Shinriki S., Ikeda K., Ando Y.
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Journal Title
J. Neurol.
Volume: 262
Issue: 8
Pages: 1828-1836
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 循環器医のための脳卒中講座2014
Author(s)
平野照之
Organizer
第1回日本心血管脳卒中学会学術集会
Place of Presentation
大宮ソニックシティ
Year and Date
2014-06-06 – 2014-06-07
Related Report
Invited
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