A novel electrophysiological method to detect muscle fatigue in myasthenia gravis

• Project/Area Number: 25461321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Sapporo Medical University
• Principal Investigator: Imai Tomihiro 札幌医科大学, 保健医療学部, 教授 (40231162)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO DAISUKE 札幌医科大学, 医学部, 研究員 (00514556) ; TSUDA EMIKO 札幌医科大学, 医学部, 助教 (90464495)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 重症筋無力症 / 筋疲労 / 興奮収縮連関 / 反復刺激試験 / テタヌス刺激後増強 / 加速度 / 咬筋 / 冷却 / アイスパックテスト / カルシウムイオン / 反復刺激後増強 / 短母指外転筋 / 反復刺激増強

Outline of Final Research Achievements

This study demonstrated that our novel method using an accelerometer was used to evaluate post-tetanic potentiation of muscle twitch in myasthenia gravis. Significant decrease in post-tetanic potentiation of muscle twitch may be associated with impairment of excitation-contraction coupling in myasthenia gravis. The present method has high sensitivity in detecting impairment of excitation-contraction coupling in myasthenia gravis.

Research Products

• [Journal Article] Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis (2016)
  • Author(s): Daisuke Yamamoto, Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Rika Yamauchi, Shin Hisahara, Jun Kawamata, Shun Shimohama
  • Journal Title: Clinical Neurophysiology Volume: 127 Issue: 2 Pages: 1689-1693
  • DOI: 10.1016/j.clinph.2015.10.037
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] A possible electrophysiological mechanism underlying the ice pack test in myasthenia gravis (2015)
  • Author(s): Daisuke Yamamoto, Tomihiro Imai, Emiko Tsuda, Shun Shimohama
  • Organizer: American Association of Neuromuscular & Electrodiagnostic Medicine
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-10-31
  • Int'l Joint Research
• [Presentation] A possible electrophysiological mechanism underlying ice pack test (2015)
  • Author(s): 山本大輔，今井富裕，津田笑子，下濱俊
  • Organizer: 第56回日本神経学会総会
  • Place of Presentation: 朱鷺メッセ（新潟市）
  • Year and Date: 2015-05-20
• [Presentation] 興奮収縮連関障害：up-to-date (2014)
  • Author(s): 今井富裕
  • Organizer: 日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-21
• [Presentation] アイスパックテストの電気生理学的検討 (2014)
  • Author(s): 山本大輔，今井富裕，津田笑子，下濱俊
  • Organizer: 日本神経学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-22
• [Presentation] 重症筋無力症における興奮収縮連関の障害：反復刺激後増強法による検討
  • Author(s): 山本大輔
  • Organizer: 日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] Impairment of excitation-contraction coupling in myasthenia gravis – a new method using post-tetanic potentiation
  • Author(s): Daisuke Yamamoto
  • Organizer: International Congress of Clinical Neurophysiology
  • Place of Presentation: ベルリン