A novel electrophysiological method to detect muscle fatigue in myasthenia gravis
| Project/Area Number |
25461321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Imai Tomihiro 札幌医科大学, 保健医療学部, 教授 (40231162)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO DAISUKE 札幌医科大学, 医学部, 研究員 (00514556)
TSUDA EMIKO 札幌医科大学, 医学部, 助教 (90464495)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 重症筋無力症 / 筋疲労 / 興奮収縮連関 / 反復刺激試験 / テタヌス刺激後増強 / 加速度 / 咬筋 / 冷却 / アイスパックテスト / カルシウムイオン / 反復刺激後増強 / 短母指外転筋 / 反復刺激増強 |
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| Outline of Final Research Achievements |
This study demonstrated that our novel method using an accelerometer was used to evaluate post-tetanic potentiation of muscle twitch in myasthenia gravis. Significant decrease in post-tetanic potentiation of muscle twitch may be associated with impairment of excitation-contraction coupling in myasthenia gravis. The present method has high sensitivity in detecting impairment of excitation-contraction coupling in myasthenia gravis.
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Report
(4 results)
Research Products
(7 results)
