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A novel electrophysiological method to detect muscle fatigue in myasthenia gravis

Research Project

Project/Area Number 25461321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionSapporo Medical University

Principal Investigator

Imai Tomihiro  札幌医科大学, 保健医療学部, 教授 (40231162)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO DAISUKE  札幌医科大学, 医学部, 研究員 (00514556)
TSUDA EMIKO  札幌医科大学, 医学部, 助教 (90464495)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords重症筋無力症 / 筋疲労 / 興奮収縮連関 / 反復刺激試験 / テタヌス刺激後増強 / 加速度 / 咬筋 / 冷却 / アイスパックテスト / カルシウムイオン / 反復刺激後増強 / 短母指外転筋 / 反復刺激増強
Outline of Final Research Achievements

This study demonstrated that our novel method using an accelerometer was used to evaluate post-tetanic potentiation of muscle twitch in myasthenia gravis. Significant decrease in post-tetanic potentiation of muscle twitch may be associated with impairment of excitation-contraction coupling in myasthenia gravis. The present method has high sensitivity in detecting impairment of excitation-contraction coupling in myasthenia gravis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis2016

    • Author(s)
      Daisuke Yamamoto, Tomihiro Imai, Emiko Tsuda, Takayoshi Hozuki, Rika Yamauchi, Shin Hisahara, Jun Kawamata, Shun Shimohama
    • Journal Title

      Clinical Neurophysiology

      Volume: 127 Issue: 2 Pages: 1689-1693

    • DOI

      10.1016/j.clinph.2015.10.037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] A possible electrophysiological mechanism underlying the ice pack test in myasthenia gravis2015

    • Author(s)
      Daisuke Yamamoto, Tomihiro Imai, Emiko Tsuda, Shun Shimohama
    • Organizer
      American Association of Neuromuscular & Electrodiagnostic Medicine
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A possible electrophysiological mechanism underlying ice pack test2015

    • Author(s)
      山本大輔,今井富裕,津田笑子,下濱俊
    • Organizer
      第56回日本神経学会総会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 興奮収縮連関障害:up-to-date2014

    • Author(s)
      今井富裕
    • Organizer
      日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] アイスパックテストの電気生理学的検討2014

    • Author(s)
      山本大輔,今井富裕,津田笑子,下濱俊
    • Organizer
      日本神経学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 重症筋無力症における興奮収縮連関の障害:反復刺激後増強法による検討

    • Author(s)
      山本大輔
    • Organizer
      日本神経学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Impairment of excitation-contraction coupling in myasthenia gravis – a new method using post-tetanic potentiation

    • Author(s)
      Daisuke Yamamoto
    • Organizer
      International Congress of Clinical Neurophysiology
    • Place of Presentation
      ベルリン
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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