| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Pancreatic beta cells form islets of Langerhans and the feature is needed for integrated insulin secretory responses. We hypothesized that gap junction between neighboring beta cells plays a role in the integrated secretory regulation and studied the mechanism of signal transduction through gap junction. By construction of analysis tools of signal transduction between beta cells, propagation of signal transduction to neighboring cells could be detected. The propagation was not strong and lasting like cardiac myocytes. Connexin 36 was shown to be responsible for secretory function, but the inhibition of its expression by present experimental system seems to be weak. Therefore, new system for regulation of the expression are needed for analysis of gap junction.
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