Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization
Project/Area Number |
25461332
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
Yahagi Naoya 筑波大学, 医学医療系, 准教授 (60420246)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 糖・脂質代謝 / 神経 / グリコーゲン / 代謝 / 肝臓 / 生体情報 / 神経伝達物質 / GPCR / Metabolism / Neuronal informatics / Lipolysis / Obesity |
Outline of Final Research Achievements |
During fasting, animals maintain their energy balance by shifting their energy source from carbohydrates to triglycerides. Here we show that a selective hepatic vagotomy slows the speed of fat consumption by attenuating sympathetic nerve-mediated lipolysis in adipose tissue. Hepatic glycogen pre-loading by the adenoviral overexpression of glycogen synthase or the transcription factor TFE3 abolished this liver-brain-adipose axis activation. Moreover, the blockade of glycogenolysis [corrected] through the knockdown of the glycogen phosphorylase gene and the resulting elevation in the glycogen content abolished the lipolytic signal from the liver, indicating that glycogen is the key to triggering this neurocircuitry. These results demonstrate that liver glycogen shortage activates a liver-brain-adipose neural axis that has an important role in switching the fuel source from glycogen to triglycerides under prolonged fasting conditions.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue.2016
Author(s)
HirakoS, Wada N, Kageyama H, Takenoya F , Izumida Y, Kim H, IizukaY, Matsumoto A, Okabe M, Kimura A, Suzuki M, Yamanaka S, Shioda S.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of human ELOVL5 enhancer regions controlled by SREBP.2015
Author(s)
Shikama A, Shinozaki H, Takeuchi Y, Matsuzaka T, Aita Y, Murayama T, Sawada Y, Piao X, Toya N, Oya Y, Takarada A, Masuda Y, Nishi M, Kubota M, Izumida Y, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Yamada N, Shimano H, Yahagi N.
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Journal Title
Biochem Biophys Res Commun.
Volume: 465(4)
Issue: 4
Pages: 857-63
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.2013
Author(s)
Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H
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Journal Title
Nat Commun.
Volume: 4
Issue: 1
Pages: 2316-2316
DOI
Related Report
Peer Reviewed / Open Access
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