| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
This study aimed to clarify the role of S100B protein as a novel mediator for whole body chronic inflammation seen in diabetes and obesity. We utilized S100B knockout mice to address the issue. The S100B knockout mice under high fat diet showed increased insulin secretion and tended to improve glucose tolerance during oral glucose challenge as compared with wild type mice. The insulin tolerance test revealed that the knockout mice were more insulin sensitive than the mild type mice. The knockout mice showed higher levels of serum triglycerides and leptin, and altered gene expression of enzymes related to lipid and bile acid metabolism.
These novel findings indicate that S100B plays a tangible role in the metabolism of glucose and lipids, and thus S100B warrants further investigation as a novel target for the treatment of diabetes and dyslipidemia.
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