Research Project
Grant-in-Aid for Scientific Research (C)
We generated GIP-deficient mice with reduced and lacking GIP secretion and examine glucose tolerance, bone formation, and high fat diet (HFD)-induced obesity and insulin resistance. During oral glucose tolerance test (OGTT), heterozygous GIP-reduced mice (GIPgfp/+) had significantly decreased GIP levels (~50%) compared to wild-type mice (WT). In homozygous GIP-lacking mice (GIPgfp/gfp), GIP levels were undetectable. Insulin levels during OGTT were significantly lower in GIPgfp/+ and GIPgfp/gfp. Bone volume in GIPgfp/+ was similar to that in WT, while GIPgfp/gfp had decreased bone volume. Body weight gain and total body fat mass after 8 weeks of HFD were decreased in GIPgfp/+ compared to those in WT; GIPgfp/gfp had the lowest body weight and body fat mass. Insulin sensitivity in GIPgfp/+ and GIPgfp/gfp was improved compared to that in WT from data of insulin tolerance test. Thus, chronic reduction of GIP secretion alleviates obesity and insulin resistance under HFD condition.
All 2016 2015 2014 2013
All Journal Article (11 results) (of which Peer Reviewed: 11 results, Open Access: 6 results, Acknowledgement Compliant: 5 results) Presentation (12 results) (of which Invited: 5 results) Book (9 results)
Diabetol Metab Syndr.
Volume: 8 Issue: 1 Pages: 1-5
10.1186/s13098-016-0131-y
120005758426
Endocrinology
Volume: 156 Issue: 3 Pages: 837-837
10.1210/en.2014-1653
Am J Physiol Endocrinol Metab
Volume: 308 Issue: 7 Pages: 583-591
10.1152/ajpendo.00543.2014
J Diabetes Complications
Volume: 29 Issue: 3 Pages: 413-421
10.1016/j.jdiacomp.2014.12.010
J Diabetes Investig
Volume: 6 Issue: 5 Pages: 522-526
10.1111/jdi.12356
120005770745
J Diabetes Investig.
Volume: 6 Issue: 3 Pages: 302-308
10.1111/jdi.12289
Diabetes
Volume: 63 Issue: 7 Pages: 2332-2343
10.2337/db13-1563
120005458283
J Endocrinol
Volume: 222 Issue: 2 Pages: 191-200
10.1530/joe-14-0161
J Biol Chem.
Volume: 288 Issue: 3 Pages: 1929-1938
10.1074/jbc.m112.423137
120005373090
Diabetes Res Clin Pract.
Volume: 101 Issue: 2 Pages: 218-225
10.1016/j.diabres.2013.05.013
Nutrition
Volume: 29(3):549-55 Issue: 3 Pages: 549-555
10.1016/j.nut.2012.09.007
120005242568