Elucidation of the role of GIP in pancreatic glucagon secretion.
Project/Area Number |
25461345
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | The Tazuke Kofukai (2014-2015) Kyoto University (2013) |
Principal Investigator |
HAMASAKI Akihiro 公益財団法人田附興風会, 医学研究所第3研究部, 部長 (40456900)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | グルカゴン / インクレチン / GIP / 膵島 / 肥満 / GLP-1 / インスリン / インクレチン作用 / 糖尿病 / 2型糖尿病 / 膵β細胞 |
Outline of Final Research Achievements |
We performed basic experiments and clinical studies to elucidate the role of glucose-dependent insulinotropic polypeptide (GIP) in modification of glucagon secretion in diabetes and obesity. We generated and analysed tissue-specific GIP receptor knock-out mice in basic study. We also investigated the relation between glucagon secretion and incretin secretion, and clarified that GIP affected the glucagon secretion especially in postprandial state.
|
Report
(4 results)
Research Products
(23 results)
-
[Journal Article] Enteral supplement enriched with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion.2015
Author(s)
Joo E., Muraoka A., Hamasaki A., Harada N., Yamane S., Kondo Y., Suzuki K., Nasteska D., Shibue K., Harada T., Iwasaki K., Tsuji H., Shide K., Inagaki N.
-
Journal Title
J Diabetes Investig.
Volume: 6
Issue: 3
Pages: 302-308
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Fatty acid binding protein 5 (FABP5) regulates diet-induced obesity (DIO) via GIP secretion from enteroendocrine K-cells in response to fat ingestion.2015
Author(s)
Shibue, K., Yamane, S., Harada, N., Hamasaki, A., Suzuki, K., Joo, E., Iwasaki, K., Nasteska, D., Harada, T., Hayashi, Y., Adachi, Y., Owada, Y., Takayanagi, R. and Inagaki, N.
-
Journal Title
Am J Physiol Endocrinol Metab
Volume: 308
Issue: 7
Pages: 583-591
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K-cells of upper small intestine and has a critical role in GIP secretion after fat ingestion.2015
Author(s)
Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Joo E, Nasteska D, Shibue K, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N.
-
Journal Title
Endocrinology
Volume: 156
Issue: 3
Pages: 837-837
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high fat diet condition.2014
Author(s)
Nasteska, D., Harada, N., Suzuki, K., Yamane, S., Hamasaki, A., Joo, E., Mori, K., Shibue, K., Harada, T., Inagaki, N.
-
Journal Title
Diabetes
Volume: 63
Issue: 7
Pages: 2332-2343
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity.2013
Author(s)
Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N.
-
Journal Title
J Biol Chem.
Volume: 288
Issue: 3
Pages: 1929-1938
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice2013
Author(s)
Joo E, Yamane S, Hamasaki A, Harada N, Matsunaga T, Muraoka A, Suzuki K, Nasteska D, Fukushima T, Hayashi T, Tsuji H, Shide K, Tsuda K, Inagaki N
-
Journal Title
Nutrition
Volume: 29(3):549-55
Issue: 3
Pages: 549-555
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Glucose-dependent Insulinotropic Polypeptide (GIP) Is Involved in Inappropriate Glucagon Secretion in Response to Oral Glucose Loading in Type 2 Diabetes2014
Author(s)
Hamasaki A, Muraoka A, Harada N, Yamane S, Joo E, Suzuki K, Kondo Y, Shibue K, Harada T, Iwasaki K, Inagaki N
Organizer
10th IDF-WPR CONGRESS 2014 | 6th AASD Scientific Meeting
Place of Presentation
Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
-
[Presentation] Relationship between Fatty Acid Profile and Incretin Effect in Normal Glucose Tolerance2014
Author(s)
Muraoka A, Hamasaki A, Harada N, Yamane S, Joo E, Suzuki K, Konodo Y, Shibue K, Harada T, Iwasaki K, Inagaki N
Organizer
10th IDF-WPR CONGRESS 2014 | 6th AASD Scientific Meeting
Place of Presentation
Singapore
Year and Date
2014-11-21 – 2014-11-24
Related Report
-
[Presentation] Inhibition of GIP receptor signalling in adipose tissue reduces insulin resistance in high fat diet-induced obesity2014
Author(s)
E. Joo, N. Harada, T. Fukushima, A. Hamasaki, S. Yamane, K. Iwasaki, D. Nasteska, K. Shibue, T. Harada, K. Suzuki, N. Inagaki
Organizer
50th European association for the study of diabetes annual meeting
Place of Presentation
Vienna
Year and Date
2014-09-15 – 2014-09-19
Related Report
-
-
-
-
[Presentation] Lowering GIP secretion is beneficial for reducing obesity and insulin resistance without impairing glucose tolerance and osteogenesis2013
Author(s)
Daniela Nasteska, Norio Harada, Shunsuke Yamane, Kazuyo Suzuki, Akihiro Hamasaki, Erina Joo, Kazuki Sasaki, Atsushi Muraoka, Kimitaka Shibue, Takanari Harada, Yaeko Kondo, Nobuya Inagaki
Organizer
第56回日本糖尿病学会年次学術集会
Place of Presentation
熊本
Related Report
-
-
[Presentation] Distribution of fatty acid binding receptors in GIP-secreting K cells in the small intestine
Author(s)
K.Mori,N.Harada,K.Suzuki,S.Yamane,A.Hamasaki,K.Sasaki,D.Nasteska,E.Joo,K.Shibue,T.Harada,N.Inagaki
Organizer
49th EASD Annual Meeting
Place of Presentation
barcelona, Spain
Related Report
-
[Presentation] Inhibition of GIP Receptor signaling in adipose tissue improves insulin sensitivity under high fat diet-induced obesity
Author(s)
E.Joo,N.Harada,A.Hamasaki,K.Mori,T.Fukushima,K.Shibue,D.Nasteska,K.Suzuki,T.Harada,S.Yamane,T.Hayashi,K.Tsuda,N.Inagaki
Organizer
5th AASD
Place of Presentation
Seoul, Korea
Related Report