• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of non-invasive risk stratification systems for diabetic macroangiopathy

Research Project

Project/Area Number 25461349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionOsaka University

Principal Investigator

KATAKAMI NAOTO  大阪大学, 医学(系)研究科(研究院), 寄附講座講師 (10403049)

Co-Investigator(Kenkyū-buntansha) MATSUOKA Taka-aki  大阪大学, 医学系研究科, 講師 (10379258)
KANETO Hideaki  川崎医科大学, 医学部, 教授 (80448034)
Yasuda Tetsuyuki  大阪大学, 医学系研究科, 助教 (30448055)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords糖尿病大血管症 / 心血管疾患 / 頸動脈エコー / IMT / 超音波組織性状 / 遺伝子多型 / 脈波伝播速度 / 糖尿病 / baPWV
Outline of Final Research Achievements

Cardiovascular disease (CVD) leads to the impairment of quality of life and is one of the major causes of mortality, and once it has developed, diabetic patients have worse outcome as compared to non-diabetic patients. Although early detection of the patients to treat will allow clinical interventions to prevent CVD, cardiovascular risk assessment based on conventional risk factors showed only moderate performance. As simple, non-invasive, and inexpensive procedure, carotid ultrasound and measurement of brachial-ankle pulse wave velocity (baPWV) are candidates of the useful tools to assess near future risk at individual level. In this study, we revealed that measurement of carotid intima-media thickness and baPWV as well as ultrasonic tissue characterization of carotid plaques improved the ability to identify the diabetic individuals with high risk for CVD. In addition, a polygenic assessment approach can be a super-early diagnostic tool to identify high risk individuals.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 6 results)

  • [Journal Article] Different Impacts of Cardiovascular Risk Factors on Arterial Stiffness versus Arterial Wall Thickness in Japanese Patients with Type 2 Diabetes Mellitus2015

    • Author(s)
      Takahara M, Katakami N, Osonoi T, Saitou M, Sakamoto F, Matsuoka TA, Shimomura I.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 9 Pages: 971-980

    • DOI

      10.5551/jat.29090

    • NAID

      130005099301

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of oxidative-stress related gene polymorphisms and the risk of coronary heart disease events in type 2 diabetes in an 8-year follow-up.2014

    • Author(s)
      1.Katakami N, Kaneto H, Matsuoka TA, Takahara M, Osonoi T, Saitou M, Kawai K, Ishibashi F, IKashiwagi A, Kawamori R, Shimomura I, Yamasaki Y
    • Journal Title

      Atherosclerosis

      Volume: 235 Issue: 2 Pages: 408-414

    • DOI

      10.1016/j.atherosclerosis.2014.05.936

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients.2014

    • Author(s)
      Katakami N, Osonoi T, Takahara M, Saitou M, Matsuoka TA, Yamasaki Y, Shimomura I.
    • Journal Title

      Cardiovascular Diabetology

      Volume: 13 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s12933-014-0128-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carotid ultrasonograpy: a potent tool for better clinical practice of atherosclerosis in diabetic patients.2014

    • Author(s)
      Katakami N, Kaneto H, Shimomura I.
    • Journal Title

      Journal of Diabetes Investigation 2013

      Volume: 5 Issue: 1 Pages: 3-13

    • DOI

      10.1111/jdi.12106

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The utility of carotid ultrasonography in identifying severe coronary artery disease in asymptomatic type 2 diabetes patients without history of coronary artery disease.2013

    • Author(s)
      Irie Y, Katakami N, Kaneto H, Nishio M, Kasami R, Sakamoto K, Umayahara Y, Sumitsuji S, Ueda Y, Kosugi K, Shimomura I.
    • Journal Title

      Diabetes Care

      Volume: 36 Issue: 5 Pages: 1327-1334

    • DOI

      10.2337/dc12-1327

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The utility of ultrasonic tissue characterization of carotid plaque in the prediction of cardiovascular events in diabetic patients.2013

    • Author(s)
      Irie Y, Katakami N, Kaneto H, Takahara M, Nishio M, Kasami R, Sakamoto K, Umayahara Y, Sumitsuji S, Ueda Y, Kosugi K, Shimomura I.
    • Journal Title

      Atherosclerosis

      Volume: 230 Issue: 2 Pages: 399-405

    • DOI

      10.1016/j.atherosclerosis.2013.08.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病の無症候性冠動脈疾患のサロゲートマーカー2016

    • Author(s)
      片上直人
    • Organizer
      第2回 日本慢性疾患重症化予防学会
    • Place of Presentation
      兵庫
    • Year and Date
      2016-02-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病合併症の遺伝素因 ~大血管症を中心に~2015

    • Author(s)
      片上直人
    • Organizer
      第30回 日本糖尿病合併症学会学術集会
    • Place of Presentation
      愛知
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] “頸動脈エコーで診る” ~心血管イベントの発症抑制に向けて~2015

    • Author(s)
      片上直人
    • Organizer
      第42回 日本超音波医学会関西地方会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病における酸化ストレスと動脈硬化性疾患 ~予防と早期診断に向けて~2015

    • Author(s)
      片上直人
    • Organizer
      第15回 NO学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病における酸化ストレスと動脈硬化性疾患2015

    • Author(s)
      片上直人
    • Organizer
      第15回 日本抗加齢医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病大血管症の発症予測における上腕-足首間脈波伝播速度(baPWV)の有用性の検討2015

    • Author(s)
      片上直人、遅野井健、高原充佳、斉藤美代子、山本裕一、久保典代、坂本扶美枝、河盛段、安田哲行、松岡孝昭、山崎義光、下村伊一郎
    • Organizer
      第58回 日本糖尿病学会年次学術集会
    • Place of Presentation
      山口
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖尿病合併症の遺伝素因 ~大血管症を中心に~2014

    • Author(s)
      片上直人
    • Organizer
      第51回 日本糖尿病学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 非侵襲的アプローチによる頸動脈壁組織性状の定量評価とその臨床的有用性2013

    • Author(s)
      片上直人、高原充佳、金藤秀明、坂本賢哉、吉内和富、坂本扶美枝、入江陽子、久保典代、桂 央士、山崎義光、小杉圭右、下村伊一郎
    • Organizer
      第56回 日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 冠動脈疾患の既往がない無症候2型糖尿病患者において頚動脈内膜中膜複合体肥厚度は重症冠動脈疾患のスクリーニングに有用である2013

    • Author(s)
      入江陽子、片上直人、金藤秀明、嵩 龍一、坂本賢哉、小杉圭右、馬屋原 豊、下村伊一郎
    • Organizer
      第56回 日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 1型糖尿病における大血管障害~その早期診断と進展予防を目指して~2013

    • Author(s)
      片上直人
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 糖尿病大血管障害の早期診断~心血管イベント発症抑制に向けて~2013

    • Author(s)
      片上直人
    • Organizer
      第50回日本糖尿病学会近畿地方会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi