| Project/Area Number |
25461359
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
OSAWA HARUHIKO 愛媛大学, 医学(系)研究科(研究院), 教授 (90294800)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ONUMA HIROSHI 愛媛大学, 大学院医学系研究科, 准教授 (00294794)
TAKATA YASUNORI 愛媛大学, 医学部附属病院, 講師 (20432792)
KAWAMURA RYOICHI 愛媛大学, 医学部附属病院, 講師 (90533092)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TABARA YASUHARU 愛媛大学, 医学部附属病院, 講師 (00268749)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | レジスチン / インスリン抵抗性 / SNP / エピジェネティクス / 遺伝子発現 / 2型糖尿病 / 遺伝子 / 環境因子 |
|---|
| Outline of Final Research Achievements |
Resistin causes insulin resistance, a feature of type 2 diabetes. We analyzed how genetic, epigenetic, and environmental factors affected resistin gene expression. In 2078 subjects in the Japanese general population, plasma resistin was highest in the G/G genotype, followed by C/G and C/C. In contrast, the methylation at SNP-420 was highest in the C/C genotype, followed by C/G and G/G. When the methylation was assessed in the C/C or C/G genotype, the methylation was inversely associated with plasma resistin. Therefore, plasma resistin was associated with both the genotype and methylation at SNP-420.
|
