Impacts of Local Macrophage Proliferation on Atherosclerotic Plaque Progression and Obesity-associated Adipose Tissue Inflammation.
| Project/Area Number |
25461361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Takeshi 熊本大学, 医学部付属病院, 講師 (20398192)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マクロファージ増殖 / 動脈硬化 / インスリン抵抗性 / 脂肪浸潤マクロファージ / 動脈硬化症 |
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| Outline of Final Research Achievements |
To verify the direct evidence of involvement of Mφ proliferation in atherosclerosis and adipose tissue inflammation, we have generated Tg mice whose Mφ proliferation is specifically suppressed by the macrophage-specific p27kip expression. The atherosclerotic plaque formation was significantly reduced by Mφ growth inhibition. Mφs were less accumulated and the necrotic core formation was significantly decreased in Tg mice. The HFD-fed Tg showed improved insulin sensitivity. The crown-like structure formations was significantly reduced in Tg along with decreased inflammatory cytokine expression in adipose tissue.
The excess inflammatory responses in the atherosclerotic lesion and the adipose tissue were ameliorated by Mφ growth inhibition. The local Mφ proliferation could be the common pathophysiological feature in the progression of atherosclerosis and dietary-induced insulin resistance.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway2015
Author(s)
Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
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Journal Title
Circulation
Volume: 132(12)
Issue: 12
Pages: 1081-1093
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.2014
Author(s)
Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun
Volume: 457
Issue: 1
Pages: 23-20
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014
Author(s)
Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
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Journal Title
Cell Metab.
Volume: 9
Issue: 4
Pages: 712-721
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Statin-mediated PPARγ activation in adipocytes may improve glucose tolerance in high fat-fed mice.2014
Author(s)
Takafumi Senokuchi, Takeshi Matsumura, Kazuki Fukuda, Norio Ishii, Hiroyuki Kinoshita, Sarie Yamada, Saiko Murakami, Tatsuya Kondo, Hiroyuki Motoshima, Takeshi Nishikawa, Eiichi Araki
Organizer
6th AASD Scientific Meeting
Place of Presentation
Singapore
Year and Date
2014-09-21 – 2014-09-24
Related Report
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