| Project/Area Number |
25461365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI TAKAKO 昭和大学, 医学部, 准教授 (00175499)
UEDA TOSHIHIKO 昭和大学, 医学部, 講師 (20175219)
IWAI SHINICHI 昭和大学, 薬学部, 教授 (70317519)
SAITO YUTA 昭和大学, 医学部, 講師 (70407477)
山本 剛 昭和大学, 歯学部, その他 (80384189)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIYAMA YOSHIAKI 大阪大学, 医学部, 准教授 (60372611)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ぺリオスチン / 糖尿病網膜症 / 血管新生 / 細胞外基質 / 増殖膜 / 黄斑上膜 |
|---|
| Outline of Final Research Achievements |
Periostin is an extracellular matrix protein that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Recently, it was shown that periostin promotes cardiac repair and remodeling. However, it is unclear that periostin plays a role in neovascularization and fibrovascular proliferation in proliferative diabetic retinopathy (PDR). Therefore, we examined the role of periostin in neovascularization and fibrovascular proliferation in PDR.
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