Analysis of role of periostin in proliferative diabetic retinopathy

Research Project

Project/Area Number	25461365
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Teikyo University
Principal Investigator	BAN YOSHIYUKI 帝京大学, 医学部, 講師 (00317554)
Co-Investigator(Kenkyū-buntansha)	NAKANISHI TAKAKO 昭和大学, 医学部, 准教授 (00175499) UEDA TOSHIHIKO 昭和大学, 医学部, 講師 (20175219) IWAI SHINICHI 昭和大学, 薬学部, 教授 (70317519) SAITO YUTA 昭和大学, 医学部, 講師 (70407477) 山本剛昭和大学, 歯学部, その他 (80384189)
Co-Investigator(Renkei-kenkyūsha)	TANIYAMA YOSHIAKI 大阪大学, 医学部, 准教授 (60372611)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ぺリオスチン / 糖尿病網膜症 / 血管新生 / 細胞外基質 / 増殖膜 / 黄斑上膜
Outline of Final Research Achievements	Periostin is an extracellular matrix protein that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Recently, it was shown that periostin promotes cardiac repair and remodeling. However, it is unclear that periostin plays a role in neovascularization and fibrovascular proliferation in proliferative diabetic retinopathy (PDR). Therefore, we examined the role of periostin in neovascularization and fibrovascular proliferation in PDR.