| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Diabetes mellitus increases risk for various CNS disorders including cognitive impairment. We focused on alterations in sterol metabolism in the brain. In diabetic mouse brains, cholesterol biosynthesis is reduced due to insufficient insulin action, accompanied by down-regulation of a sterol-sensor molecule SCAP. We found that haploinsufficiency of Scap gene in the whole brain caused impaired cognitive function. AMPK activation, mimicking a diabetic state in the brain, reduced SCAP in astroglial cells. Furthermore, induction of SCAP deficiency in astrocytes provoked disturbances in long-term memory and social cognition.
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