Diabetes-induced disturbances in energy and lipid metabolism in the brain
Project/Area Number |
25461373
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
Suzuki Ryo 東京大学, 医学部附属病院, 講師 (20396732)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 糖尿病 / 脳 / SCAP / 認知機能 / アストロサイト / ステロール / 脳脂質代謝 / コレステロール合成 / AMPK |
Outline of Final Research Achievements |
Diabetes mellitus increases risk for various CNS disorders including cognitive impairment. We focused on alterations in sterol metabolism in the brain. In diabetic mouse brains, cholesterol biosynthesis is reduced due to insufficient insulin action, accompanied by down-regulation of a sterol-sensor molecule SCAP. We found that haploinsufficiency of Scap gene in the whole brain caused impaired cognitive function. AMPK activation, mimicking a diabetic state in the brain, reduced SCAP in astroglial cells. Furthermore, induction of SCAP deficiency in astrocytes provoked disturbances in long-term memory and social cognition.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Calorie restriction-mediated restoration of hypothalamic signal transducer and activator of transcription 3 (STAT3) phosphorylation is not effective for lowering the body weight set point in IRS-2 knockout obese mice2015
Author(s)
Senda S, Inoue A, Mahmood A, Suzuki R, Kamei N, Kubota N, Watanabe T, Aoyama M, Nawaz A, Ohkuma Y, Tsuneyama K, Koshimizu Y, Usui I, Saeki K, Kadowaki T and Tobe K.
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Journal Title
Diabetology International
Volume: 6
Issue: 4
Pages: 321-335
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Deregulation of Pancreas-Specific Oxidoreductin ERO1beta in the Pathogenesis of Diabetes Mellitus2014
Author(s)
Awazawa, M. Futami, T. Sakada, M. Kaneko, K. Ohsugi, M. Nakaya, K. Terai, A. Suzuki, R. Koike, M. Uchiyama, Y. Kadowaki, T. Ueki, K.
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Journal Title
Mol Cell Biol
Volume: 34
Issue: 7
Pages: 1290-1299
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 糖尿病と認知症2015
Author(s)
鈴木亮
Organizer
第30回日本糖尿病合併症学会
Place of Presentation
名古屋
Year and Date
2015-11-27
Related Report
Invited
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[Presentation] 脳の脂質代謝と糖尿病2014
Author(s)
鈴木亮
Organizer
第87回日本内分泌学会学術総会
Place of Presentation
福岡国際会議場(福岡)
Year and Date
2014-04-25
Related Report
Invited
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