| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
We investigated the anti-atherogenic effects on cPLA2 and apoE double knockout mice (cPLA2/apoE KO mice). PPARgannma activity was increased in peritoneal macrophage of cPLA2/apoE KO mice. LPS-induced mRNA expression of TNF-alpha and MCP-1 was decreased, and mRNA expression ABCA1/G1 was increased in peritoneal macrophage of cPLA2/apoE KO mice. Moreover, atherosclerotic lesion formation on cPLA2/apoE KO mice was lower than that on control apoE KO mice. These results suggest that cPLA2 is involved in atherosclerotic lesion formation in apoE KO mice, and that may be therapeutic target for diabetic macrovascular complications.
|
