• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

G protein-coupled receptor:its crosstalk, diseases, and regulation

Research Project

Project/Area Number 25461382
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionSt. Marianna University School of Medicine (2014-2015)
The University of Tokyo (2013)

Principal Investigator

Iiri Taroh  聖マリアンナ医科大学, 医学部, 教授 (90313022)

Co-Investigator(Kenkyū-buntansha) MAKITA NORIKO  東京大学, 医学部付属病院, 講師 (60353455)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGタンパク質共役受容体 / GPCR / NO / nitrosylation / 臓器障害と保護 / メタボリックシンドローム / シグナルクロストーク / RhoA / 臓器障害 / クロストーク
Outline of Final Research Achievements

We have investigated the molecular mechanism of the crosstalk between Gs-coupled receptors and Gq/G13-coupled receptors, focusing on RhoA/RhoGDI function, and have found that RhoGDI phosphorylation by A-kinase serves as the specific inhibitory mechanism of Gq/G11-coupled receptor signaling. We have also investigated the molecular mechanism of desensitization of Gs-coupled receptor, focusing on GPCR kinase 2 (GRK2), and shown that our novel chemicals that induce nitrosylation of GRK2 inhibit GRK2 function and desensitization of β-adrenergic receptor, thus clarifying the signal crosstalk between NO and GPCRs. We have also quantitatively shown that angiotensin receptor blockers (ARBs) show dual actions, i.e., inverse agonist activity to AT1 receptor and anti-inflammation activity against adipocytes/macrophages.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Invited: 9 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Inverse agonism: the classic concept of GPCRs revisited2016

    • Author(s)
      Sato J, Mkita N, and Iiri T.
    • Journal Title

      Endocrine Journal

      Volume: online

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPCR研究の最前線20162016

    • Author(s)
      飯利太朗、槙田紀子
    • Journal Title

      医学のあゆみ

      Volume: 256(5) Pages: 347-833

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Successful gycemic control with three times a week degludec injection by medical staff for an elderly hemodialysis patient with type 2 diabetes.2015

    • Author(s)
      Oishi A, Makita N, Manaka K, Mitani K, Tomita H, Iiri T.
    • Journal Title

      Diabetol Int

      Volume: online Issue: 1 Pages: 95-99

    • DOI

      10.1007/s13340-015-0220-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPCRキナーゼのニトロシル化による制御と創薬戦略2015

    • Author(s)
      飯利太朗、槙田紀子
    • Journal Title

      日本薬理学会雑誌

      Volume: 145 Pages: 1-4

    • NAID

      130004827708

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biased agonism: a novel paradigm in G protein-coupled receptor signaling observed in acquired hypocalciuric hypercalcemia.2014

    • Author(s)
      Makita N, Iiri T.
    • Journal Title

      Endocr. J.

      Volume: 61 Pages: 303-309

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Erdheim-Chester disease and pituitary involvement: a unique case and the literature.2014

    • Author(s)
      Manaka K, Makita N, Iiri T.
    • Journal Title

      Endocr. J.

      Volume: 61 Pages: 185-194

    • NAID

      130004718267

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] G蛋白質共役受容体2014

    • Author(s)
      飯利太朗、槙田紀子
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 368-368

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Temporary dual-chamber pacing can stabilize hemodynamics during noncardiac surgery in a patient with left ventricular hypertrophy and outflow obstruction.2014

    • Author(s)
      Kojima T, Imai Y, Tsushima K, Uno K, Fujiu K, Iiri T, Nishimatsu H, Suzuki T, Sugiyama H, Asada K, Nakao T, Yamashita H, Hirata Y, Nagai R.
    • Journal Title

      J Cardiothorac Vasc Anesth.

      Volume: 28 Issue: 1 Pages: 124-7

    • DOI

      10.1053/j.jvca.2012.07.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Biased agonism: a novel paradigm in G protein-coupled receptor signaling observed in acquired hypocalciuric hypercalcemia [Review]2014

    • Author(s)
      Makita N, Iiri T.
    • Journal Title

      Endocrine Journal

      Volume: 61 Issue: 4 Pages: 303-309

    • DOI

      10.1507/endocrj.EJ13-0453

    • NAID

      130004443953

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tyrosine Kinase Inhibitor-Induced Thyroid Disorders: A Review and Hypothesis2013

    • Author(s)
      Makita N and Iiri T.
    • Journal Title

      Thyroid

      Volume: 23 Issue: 2 Pages: 151-159

    • DOI

      10.1089/thy.2012.0456

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iiri T Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDIa2012

    • Author(s)
      Oishi A, Makita N, Sato J
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 46 Pages: 38705-15

    • DOI

      10.1074/jbc.m112.401547

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Gタンパク質共役受容体:GRKを標的とする制御と創薬戦略2016

    • Author(s)
      飯利太朗、槙田紀子
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      日本科学未来館未来館ホール((東京都・江東区)
    • Year and Date
      2016-05-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] カルシウム感知受容体:まれな疾患からGPCRの新しいパラダイムへ2016

    • Author(s)
      飯利太朗、槙田紀子
    • Organizer
      第89回日本内分泌学会
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 部分型腎性尿崩症の原因となる V2 受容体変異体の機能解析から得られる新たな治験2016

    • Author(s)
      槙田紀子、矢嶋由紀、三谷康二、間中勝則、佐藤潤一郎、南学正臣、飯利太朗
    • Organizer
      第89回日本内分泌学会
    • Place of Presentation
      京都国際会議場(京都府・京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] カルシトニン遺伝子関連ペプチドによるRas/MEK/ERK経路を介した肝癌細胞株の細胞増殖抑制作用2016

    • Author(s)
      武半優子、原雅樹、渡辺実、飯利太朗、太田有紀、大滝正訓、松本直樹
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自然発症不妊症ラットの生殖機能異常2016

    • Author(s)
      渡辺実、田中政巳、武半優子、大滝正訓、太田有紀、飯利太朗、熊井俊夫、松本直樹
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 聖マリアンナ医科大学におけるヒト組織バンクの情報管理の取り組み2015

    • Author(s)
      大滝正訓、原雅樹、太田有紀、 渡辺実、 熊井俊夫、 飯利太朗、 松本直樹
    • Organizer
      第36回日本臨床薬理学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌細胞に対する新規KSP阻害薬の効果2015

    • Author(s)
      太田有紀、土屋聖子、大滝正訓、渡辺実、武半優子、飯利太朗、松本直樹
    • Organizer
      第36回日本臨床薬理学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Gタンパク質共役受容体:GPCRキナーゼの制御と創薬戦略2015

    • Author(s)
      飯利太朗、槙田紀子
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都、新宿区)
    • Year and Date
      2015-07-03 – 2015-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Gタンパク質共役受容体:GPCRキナーゼの制御と創薬戦略2015

    • Author(s)
      飯利太朗、槙田紀子、松本直樹
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新しい部分型尿崩症の機能解析と新たな治療薬の検討2015

    • Author(s)
      槙田紀子、佐藤智彦、矢嶋由紀、三谷康二、間中勝則、大石篤郎、佐藤潤一郎、南学正臣、飯利太朗
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      ホテルニューオータニ東京(東京都・千代田区)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 仮面尿崩症を契機に診断されたIgG4関連漏斗下垂体炎の一例 第88回 日本内分泌学会2015

    • Author(s)
      柴田智華子、間中勝則、藤田恵、伊東伸朗、高橋克敏、田口学、木下祐加、大石篤郎、矢嶋由紀、三谷康二、 槙田紀子、飯利太朗、南学正臣
    • Organizer
      第88回日本内分泌学会
    • Place of Presentation
      ホテルニューオータニ東京(東京都・千代田区)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 受容体の脱感作を制御する新たなニトロシル化薬剤2015

    • Author(s)
      槙田紀子、佐藤潤一郎、黒瀬等、大和田智彦、飯利太朗
    • Organizer
      第88回日本薬理学会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] GRK2のニトロシル化によるβアドレナリン受容体の脱感作抑制2014

    • Author(s)
      槙田紀子、佐藤潤一郎、橋本真紀子、間中勝則、大石篤郎、矢嶋由紀、三谷康二、南学正臣、大和田智彦、飯利太朗
    • Organizer
      第32回内分泌代謝学サマーセミナー
    • Place of Presentation
      富士レークホテル(山梨県、河口湖町)
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] GRK2のニトロシル化を介したβ2アドレナリン受容体の脱感作抑制と治療意義2014

    • Author(s)
      槙田紀子、佐藤潤一郎、間中勝則、大石篤郎、矢嶋由紀、三谷康二、大和田智彦、南学正臣、飯利太朗
    • Organizer
      第87回日本内分泌学会
    • Place of Presentation
      福岡国際会議場(福岡県、博多市)
    • Year and Date
      2014-04-23 – 2014-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Regulation of G protein-coupled receptor kinase and desensitization-targeted potential therapeutic approach2014

    • Author(s)
      飯利太朗、槙田紀子
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 受容体シグナルとその分子異常を原因とする疾患の解析  日本内分泌学会研究奨励賞受賞講演2013

    • Author(s)
      槙田紀子
    • Organizer
      第86回日本内分泌学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Novel human autoantibody working as a biased allosteric modulator causes acquired hypocalciuric hypercalcemia2013

    • Author(s)
      Noriko Makita and Taroh Iiri
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Pisa, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Gタンパク質共役受容体の新しいパラダイム―糖尿病・高血圧治療戦略における意義2013

    • Author(s)
      飯利太朗
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本(メルパルク熊本)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Gタンパク質共役受容体の新しいパラダイム-Biased signaling and disease2013

    • Author(s)
      飯利太朗
    • Organizer
      生活習慣病の病態解明と分子標的探索セミナー
    • Place of Presentation
      群馬大学生体調節研究所
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 新しい部分型腎性尿崩症の機能解析と新たな治療薬の可能性2013

    • Author(s)
      槙田紀子、佐藤知彦、矢嶋由紀、三谷康二、間中勝則、大石篤郎、佐藤潤一郎、南学正臣、飯利太朗
    • Organizer
      第86回日本内分泌学会
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Research-status Report
  • [Book] G蛋白質共役受容体(GPCR)2014

    • Author(s)
      飯利太朗、槙田紀子
    • Publisher
      医歯薬出版
    • Related Report
      2013 Research-status Report
  • [Remarks] 薬理学

    • URL

      http://www.marianna-u.ac.jp/houjin/staff/univ/yakuri/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 内分泌・疾患解析制御グループ

    • URL

      http://www.todai-jinnai.com/kenkyu/g_endocrinology/g03_endocrinology

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 内分泌・疾患解析制御研究グループ

    • URL

      http://www.todai-jinnai.com/kenkyu/g_endocrinology/g03_endocrinology

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi