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Investigation in the physiological effect of adiponectin through its binding protein

Research Project

Project/Area Number 25461386
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionOsaka University

Principal Investigator

Maeda Norikazu  大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (30506308)

Co-Investigator(Kenkyū-buntansha) Funahashi Tohru  大阪大学, 大学院医学(系)研究科寄附, 講座教授 (60243234)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords内分泌学 / メタボリックシンドローム / アディポネクチン / T-cadherin / GPI-PLD / GPI-アンカー蛋白 / S100A8 / 動脈硬化症 / 臓器保護 / 動脈硬化
Outline of Final Research Achievements

Adiponectin, an adipose-specific secretory protein, abundantly exists in bloodstream. Here, we showed that adiponectin accumulates onto specific tissues or cells and thus exhibits organ protective effects. Adiponectin binds to T-cadherin and accumulates onto aorta, heart, and skeletal muscle in which T-cadherin is highly expressed. Present study focused on the accumulation of adiponectin in aorta, because adiponectin has been shown to possess anti-atherosclerotic property. Adiponectin resides on aortic endothelial cells under steady condition. Interestingly, in atherosclerotic plaque lesion, adiponectin exists not only in endothelial cells but also on the surface of smooth muscle cells with synthetic phenotype and monocytes attaching to endothelial cells. Data shown here indicates that adiponectin/T-cadherin system plays a crucial role in maintaining homeostasis in vivo.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Visualized macrophage dynamics and significance of S100A8 in obese fat.2015

    • Author(s)
      Sekimoto et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: ePub Issue: 16

    • DOI

      10.1073/pnas.1409480112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.2015

    • Author(s)
      Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, Tsushima Y, Masuda S, Yamaoka M, Inoue K, Nishizawa H, Kita S, Ranscht B, Funahashi T, Shimomura I.
    • Journal Title

      Endocrinology.

      Volume: 156 Issue: 3 Pages: 934-946

    • DOI

      10.1210/en.2014-1618

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice.2014

    • Author(s)
      Mori T, Koyama Y, Maeda N, Nakamura Y, Fujishima Y, Matsuda K, Funahashi T, Shimada S, Shimomura I.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 4895-4895

    • DOI

      10.1038/srep04895

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of adiponectin on cardiac beta-catenin signaling pathway under angiotensin II infusion.2014

    • Author(s)
      Fujishima Y, Maeda N, Matsuda K, Komura N, Hirata A, Mori T, Sekimoto R, Tsushima Y, Nishizawa H, Funahashi T, Shimomura I.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 444 Issue: 2 Pages: 224-229

    • DOI

      10.1016/j.bbrc.2014.01.043

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adiponectin protein exists in aortic endothelial cells.2013

    • Author(s)
      Komura N, Maeda N, Mori T, Kihara S, Nakatsuji H, Hirata A, Tochino Y, Funahashi T, Shimomura I.
    • Journal Title

      PLoS One

      Volume: 8(8) Issue: 8 Pages: e71271-e71271

    • DOI

      10.1371/journal.pone.0071271

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of non-invasive morphological and diffusion imaging in mouse emphysema by micro-CT and hyperpolarized ^129Xe MRI2013

    • Author(s)
      Satoshi Tetsumoto, Yoshioto Takeda, Hirohiko Imai, et al.
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 掲載決定 Issue: 4 Pages: 592-600

    • DOI

      10.1165/rcmb.2012-0350oc

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] T-cadherin-mediated accumulation of adiponectin protein in cardiovascular system and its physiological and pathological significance2015

    • Author(s)
      Norikazu Maeda, Yuya Fujishima, Keisuke Matsuda, Takuya Mori, Shigeki Masuda, Shunbun Kita, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura
    • Organizer
      Keystone Symposia
    • Place of Presentation
      ウェスティン都ホテル京都(京都府)
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂肪組織慢性炎症のinitial triggerとしてのS100A8の意義2015

    • Author(s)
      前田法一、堰本亮平、福田士郎、對馬 佑、松田圭介、森 卓也、中辻秀朗、西澤 均、岸田 堅、菊田順一、舞島弓子、船橋 徹、石井 優、下村伊一郎
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pathophysiological significance of tissue accumulation of adiponectin through T-cadherin2015

    • Author(s)
      前田法一、船橋 徹、下村伊一郎
    • Organizer
      The 20th Adiposcience Symposium
    • Place of Presentation
      千里阪急ホテル(大阪府)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アディポネクチン結合タンパクT-カドヘリンの代謝調節2015

    • Author(s)
      喜多俊文、小幡佳也、増田重樹、長尾博文、福田士郎、藤島裕也、山岡正弥、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館(山口県)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血中エクソソームとアディポネクチン2015

    • Author(s)
      小幡佳也、喜多俊文、増田重樹、長尾博文、福田士郎、藤島裕也、山岡正弥、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館(山口県)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] GPIアンカー切断酵素とAdipo及びTcadの発現調節連関2015

    • Author(s)
      増田重樹、藤島裕也、松田圭介、福田士郎、小幡佳也、長尾博文、山岡正弥、喜多俊文、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館(山口県)
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスのウイルス性心筋炎モデルにおいて、アディポネクチン欠損が生存率と心臓・膵に与える影響(第2報)2015

    • Author(s)
      岩本龍哉、宇野 彩、福井健司、小澤純二、前田法一、船橋 徹、岩橋博見、今川彰久、下村伊一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関市民会館(山口県
    • Year and Date
      2015-05-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] メタボリックシンドロームにおけるアディポネクチンとS100A8の意義2015

    • Author(s)
      前田法一、船橋 徹、下村伊一郎
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      シーモールパレス(山口県)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] アディポネクチン蛋白の動脈における局在変化の解析2015

    • Author(s)
      前田法一、森 卓也、小山佳之、中村雪子、堰本亮平、藤島裕也、松田圭介、船橋 徹、島田昌一、下村伊一郎
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] アディポネクチンのT-cadherinを介した心血管系組織集積と機能解析2015

    • Author(s)
      藤島裕也、森 卓也、松田圭介、喜多俊文、前田法一、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      ホテルニューオータニ東京(東京都)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cardiovascular accumulation of Adiponectin protein and its positive feedback regulation through T-cadherin2015

    • Author(s)
      Norikazu Maeda, Tohru Funahashi, Iichiro Shimomura
    • Organizer
      2015 Seoul Symposium on Obesity & Diabetes
    • Place of Presentation
      Auditorium, Biomedical Research Institute, Seoul National University Hospital(ソウル、大韓民国)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 動脈血管におけるアディポネクチンの局在解析2014

    • Author(s)
      森 卓也、小山佳之、前田法一、中村雪子、藤島裕也、松田圭介、船橋 徹、島田昌一、下村伊一郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] アディポネクチンのT-カドヘリンを介した心血管系組織集積機構の解明2014

    • Author(s)
      松田圭介、前田法一、藤島裕也、平田 歩、森 卓也、堰本亮平、小村徳幸、山岡正弥、井上佳菜、對馬 佑、西澤 均、船橋 徹、下村伊一郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎県)
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of adiponectin on cardiac β-catenin signaling pathway under angiotensin II infusion2014

    • Author(s)
      藤島裕也、松田圭介、井上佳菜、山岡正弥、平田 歩、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2014-07-10
    • Related Report
      2014 Research-status Report
  • [Presentation] アディポネクチンの心肥大抑制作用における、β-cateninシグナルの検討2014

    • Author(s)
      藤島裕也、松田圭介、井上佳菜、山岡正弥、平田 歩、西澤 均、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      リーガロイヤルホテル(大阪府)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] アディポネクチンのT-カドヘリンを介した組織集積機構の解明2014

    • Author(s)
      松田圭介、前田法一、藤島裕也、平田 歩、森 卓也、堰本亮平、小村徳幸、山岡正弥、井上佳菜、對馬 佑、西澤 均、船橋 徹、下村伊一郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] New insight into pathophysiology-based clinical application of metabolic syndrome

    • Author(s)
      Norikazu Maeda, Tohru Funahashi, Iichiro Shimomura
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本ホテルキャッスル(熊本県)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 血管内皮に存在するアディポネクチン蛋白の炎症状態における意義に関する研究

    • Author(s)
      小村徳幸、前田法一、森 卓也、松田圭介、中辻秀朗、平田 歩、木原進士、船橋 徹、下村伊一郎
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      テトリア熊本ビル(熊本県)
    • Related Report
      2013 Research-status Report
  • [Presentation] アディポネクチンがT-カドヘリン発現に与える影響

    • Author(s)
      松田圭介、平田 歩、小村徳幸、藤島裕也、西澤 均、山岡正弥、井上佳菜、森 卓也、對馬 佑、堰本亮平、前田法一、船橋 徹、下村伊一郎
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      テトリア熊本ビル(熊本県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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