Pathophysiologic significance of PACAP in hypothalamus
| Project/Area Number |
25461390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Miyata Atsuro 鹿児島大学, 医歯学域医学系, 教授 (60183969)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Kazuhiko 鹿児島大学, 医歯学域医学系, 助教 (30363641)
KAMBE Yuki 鹿児島大学, 医歯学域医学系, 助教 (60549913)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUURA Goro 鹿児島大学, 医歯学総合研究科, 特任講師 (20401226)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | PACAP / 視床下部 / 摂食 / glycogen / アストロサイト / 生理活性ペプチド / 神経内分泌 / 下垂体 |
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| Outline of Final Research Achievements |
Pituitary adenylate cyclase activating polypeptide (PACAP) is localized in hypothalamus with highest concentration. To evaluate PACAP function as a hypothalamic factor, we attempted to elucidate the regulatory mechanism of gene expression of PACAP specific receptor, PAC1. Further we tried to evaluate the function of PACAP in appetite control and energy metabolism by using PACAP-knock out (KO) mice. As a result, we found that the expression of PAC1 is negatively regulated by ER stress. As regarding glycogen metabolism, PACAP potentiates not only glycogenolysis but also glycogensesis of astrocytes. In the analysis of PACAP KO mice, their food intake were significantly decreased and the gene expression of PACAP in PACAP KO mice were significantly increased by fasting. During refeeding, the increments of gene expression of NPY and AgRP, orexigenic peptides were cancelled in PACAP KO mice. These suggest orexigenic function of PACAP in appetite control.
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Report
(4 results)
Research Products
(36 results)
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[Presentation] Acute activation of astrocytes in spinal dorsal horn VIP PAC1 receptor is involved in PACAP-induced persistent aversive behavior.2013
Author(s)
Miyata A, Yokai M, Ohno T, Hasegawa M, Kambe Y, Inoue K, Kamimura Y, Shimizu T, Kurihara T.
Organizer
The 11th International Symposium on VIP,PACAP and Related Peptides,
Place of Presentation
Pecs, HUNGARY
Related Report
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