| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Chronic hyperglycemia results in multiple vascular complications in diabetes mellitus; however, the precise mechanisms are unknown. The present study showed that hyperglycemia induces O-linked N-acetylglucosamine (O-GlcNAc) modification of mineralocorticoid receptor (MR) at the N-terminus, which is followed by elevation of MR protein levels due to inhibition of the ubiquitin-proteaosme pathway-mediated protein degradation, thus resulting in MR transactivation. The pathological MR stabilization may be involved in renal dysfunction in type 2 diabetes mellitus.
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