Investigation of mechanisms of aldosterone-induced resistant hypertension in life style-related diseases
| Project/Area Number |
25461397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルドステロン / 糖尿病 / ミネラルコルチコイド受容体 |
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| Outline of Final Research Achievements |
Chronic hyperglycemia results in multiple vascular complications in diabetes mellitus; however, the precise mechanisms are unknown. The present study showed that hyperglycemia induces O-linked N-acetylglucosamine (O-GlcNAc) modification of mineralocorticoid receptor (MR) at the N-terminus, which is followed by elevation of MR protein levels due to inhibition of the ubiquitin-proteaosme pathway-mediated protein degradation, thus resulting in MR transactivation. The pathological MR stabilization may be involved in renal dysfunction in type 2 diabetes mellitus.
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism2016
Author(s)
Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K
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Journal Title
J Clin Endocrinol Metab
Volume: 101
Issue: 1
Pages: 6-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Pore alterations of the endothelial lining of rat fenestrated intestinal capillaries exposed to acute stress.2016
Author(s)
Aosa T, Chiba S, Kitamura H, Ina K, Tatsukawa S, Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y.
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Journal Title
Histol Histopathol
Volume: epub
Related Report
Peer Reviewed
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[Journal Article] A clinical approach to brown adipose tissue in the para-aortic area of the human thorax.2015
Author(s)
Wei H, Chiba S, Moriwaki C, Kitamura H, Ina K, Aosa T, Tomonari K, Gotoh K, Masaki T, Katsuragi I, Noguchi H, Kakuma T, Hamaguchi K, Shimada T, Fujikura Y, Shibata H.
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Journal Title
PLoS One
Volume: 10
Issue: 4
Pages: e0122594-e0122594
DOI
Related Report
Peer Reviewed
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[Journal Article] Surgical outcome of laparoscopic surgery, including laparoendoscopic sngle-site surgery, for retroperitoneal paraganglioma compared with adrenal pheochromocytoma2014
Author(s)
Hattori S, Miyajima A, Hirasawa Y, Kikuchi E, Kurihara I, Miyashita K, Shibata H, Nakagawa K, Oya M
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Role of Confirmatory tests for Primary Aldosteronism Subtype Diagnosis2016
Author(s)
Ando H, Ozeki Y, Okamoto M, Okamoto M, Sato A, Yoshida Y, Anai M, Ueda S, Goto K, Masaki T, Kakuma T, Shibata H
Organizer
41st International Aldosterone Conference
Place of Presentation
The Revere Hotel Boston Common (Boston, USA)
Year and Date
2016-03-30
Related Report
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[Presentation] 副腎腫瘍の画像診断2015
Author(s)
柴田洋孝
Organizer
第８８回日本内分泌学会学術総会
Place of Presentation
ホテルニューオータニ東京（東京都千代田区）
Year and Date
2015-04-23
Related Report
Invited
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[Presentation] 副腎不全の治療の現状と展望2014
Author(s)
柴田洋孝
Organizer
第24回臨床内分泌代謝Update
Place of Presentation
大宮ソニックシティ（埼玉県さいたま市）
Year and Date
2014-11-28 – 2014-11-29
Related Report
Invited
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[Presentation] Characterization of aldosterone-producing adenomas with somatic KCNJ5 mutations2013
Author(s)
K.Yokota, H.Shibata, I.Kurihara1, K. Homma, A.Murai-Takeda, Y.Mitsuishi, R.Jo, T. Ohyama, T.Nakamura, K.Kameyama, K.Mukai, H.Itoh
Organizer
ISARSH2013
Place of Presentation
仙台国際センター（宮城県仙台市）
Related Report
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[Presentation] Mineralocorticoid receptor is pathologically activated through its O-GlcNAc modification in hyperglycemic conditions2013
Author(s)
H.Shibata, R.Jo, I.Kurihara, K.Yokota, A.Murai-Takeda, Yuko Mitsuishi1, Takeshi Hayashi1, T.Ohyama, T.Nakamura, H. Itoh
Organizer
International Aldosterone Conference 2013
Place of Presentation
The Palace Hotel (San Francisco, USA)
Related Report
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