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An establishment of serum soluble LR11, as a novel biomarker in patients with acute leukemia and malignant lymphoma

Research Project

Project/Area Number 25461409
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionChiba University

Principal Investigator

OHWADA Chikako  千葉大学, 医学部附属病院, 助教 (80436352)

Co-Investigator(Kenkyū-buntansha) NAKASEKO Chiaki  千葉大学, 大学院医学研究院, 准教授 (30323398)
TAKEUCHI Masahiro  千葉大学, 医学部附属病院, 助教 (50466702)
SAKAIDA Emiko  千葉大学, 医学部附属病院, 助教 (60422218)
Co-Investigator(Renkei-kenkyūsha) BUJO Hideaki  東邦大学, 医療センター佐倉病院, 教授 (80291300)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords新規バイオマーカー / 予後予測システム / 悪性リンパ腫 / 急性白血病 / LR11 / びまん性大細胞性B細胞型リンパ腫 / 血管内大細胞性B細胞型リンパ腫 / 血清マーカー / バイオマーカー / 急性骨髄性白血病
Outline of Final Research Achievements

LR11 is a novel identified type I membrane protein, which is highly expressed in two major hematological malignancies, acute leukemia and malignant lymphoma. Serum soluble LR11 levels were significantly elevated in newly diagnosed leukemia and lymphoma patients compared with normal controls. In regards with Diffuse Large B-cell Lymphoma (DLBCL), one of the most major type of malignant lymphoma, elevated sLR11 levels were associated with well-known prognostic factors reflecting patients' condition (PS and age) and tumor burden (serum LDH, clinical stage, and bone marrow invasion). While IPI, previously established prognostic scoring system, requires several clinical factors to calculate, serum sLR11 is a simple and powerful biomarker for predicting the high risk patients. And combination of sLR11 and IPI enables more accurate predictive system in DLBCL. Furthermore, serum sLR11 was found to be an useful diagnostic tool for distinguishing intravascular large B-cell lymphoma (IVLBCL).

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume: 印刷中 Issue: 10 Pages: 1-4

    • DOI

      10.3109/10428194.2015.1016930

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
    • Journal Title

      Leuk Lymphoma

      Volume: (印刷中) Issue: 10 Pages: 2391-2394

    • DOI

      10.3109/10428194.2014.880430

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume: 163(2) Issue: 2 Pages: 277-280

    • DOI

      10.1111/bjh.12467

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Serum soluble LR11, a novel tumor-derived circulating molecule in acute leukemia.(新規バイオマーカー、可溶型LR11の急性白血病における有用性)2015

    • Author(s)
      大和田千桂子
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      ホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Serum sLR11, a novel tumor-derived biomarker in DLBCL: A multicenter prospective analysis.2015

    • Author(s)
      竹田勇輔
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(石川県金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impact of Serum Soluble LR11 on Survival in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Multicenter Prospective Study2014

    • Author(s)
      Yasumasa Sugita, Chikako Ohwada, et al.
    • Organizer
      第56回 米国血液学会総会 Annual Meeting of American Society of Hematology
    • Place of Presentation
      米国、カルフォルニア州、サンフランシスコ
    • Year and Date
      2014-12-06 – 2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 血管内大細胞性リンパ腫(IVLBCL)の 診断におけるLR11の有用性2014

    • Author(s)
      大和田千桂子、中世古知昭、川口岳晴、竹田勇輔 、武内正博1、堺田恵美子 、清水直美 、横手幸太郎
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京、国際フォーラム
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 血清可溶型LR11(sLR11)のIntravascular large B-cell lymphoma(IVLBCL)に対する診断有用性2014

    • Author(s)
      大和田千桂子、中世古知昭、川口岳晴、竹田勇輔、武内正博、堺田惠美子、清水直美、横手幸太郎
    • Organizer
      第111回日本内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 濾胞性リンパ腫における可溶型LR11のバイオマーカーとしての有用性2013

    • Author(s)
      川口岳晴,大和田千桂子、山崎敦子、塚本祥吉、酒井紫緒、竹田勇輔、武内正博、堺田恵美子、清水直美、横手幸太郎、武城英明、中世古知昭.
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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