An establishment of serum soluble LR11, as a novel biomarker in patients with acute leukemia and malignant lymphoma

• Project/Area Number: 25461409
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Chiba University
• Principal Investigator: OHWADA Chikako 千葉大学, 医学部附属病院, 助教 (80436352)
• Co-Investigator(Kenkyū-buntansha): NAKASEKO Chiaki 千葉大学, 大学院医学研究院, 准教授 (30323398) ; TAKEUCHI Masahiro 千葉大学, 医学部附属病院, 助教 (50466702) ; SAKAIDA Emiko 千葉大学, 医学部附属病院, 助教 (60422218)
• Co-Investigator(Renkei-kenkyūsha): BUJO Hideaki 東邦大学, 医療センター佐倉病院, 教授 (80291300)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 新規バイオマーカー / 予後予測システム / 悪性リンパ腫 / 急性白血病 / LR11 / びまん性大細胞性B細胞型リンパ腫 / 血管内大細胞性B細胞型リンパ腫 / 血清マーカー / バイオマーカー / 急性骨髄性白血病

Outline of Final Research Achievements

LR11 is a novel identified type I membrane protein, which is highly expressed in two major hematological malignancies, acute leukemia and malignant lymphoma. Serum soluble LR11 levels were significantly elevated in newly diagnosed leukemia and lymphoma patients compared with normal controls. In regards with Diffuse Large B-cell Lymphoma (DLBCL), one of the most major type of malignant lymphoma, elevated sLR11 levels were associated with well-known prognostic factors reflecting patients' condition (PS and age) and tumor burden (serum LDH, clinical stage, and bone marrow invasion). While IPI, previously established prognostic scoring system, requires several clinical factors to calculate, serum sLR11 is a simple and powerful biomarker for predicting the high risk patients. And combination of sLR11 and IPI enables more accurate predictive system in DLBCL. Furthermore, serum sLR11 was found to be an useful diagnostic tool for distinguishing intravascular large B-cell lymphoma (IVLBCL).

Research Products

• [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma. (2015)
  • Author(s): Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
  • Journal Title: Leuk Lymphoma. Volume: 印刷中 Issue: 10 Pages: 1-4
  • DOI: 10.3109/10428194.2015.1016930
  • Peer Reviewed / Open Access
• [Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma (2014)
  • Author(s): Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
  • Journal Title: Leuk Lymphoma Volume: (印刷中) Issue: 10 Pages: 2391-2394
  • DOI: 10.3109/10428194.2014.880430
  • Peer Reviewed / Open Access
• [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma (2013)
  • Author(s): Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
  • Journal Title: Br J Haematol Volume: 163(2) Issue: 2 Pages: 277-280
  • DOI: 10.1111/bjh.12467
  • Peer Reviewed
• [Presentation] Serum soluble LR11, a novel tumor-derived circulating molecule in acute leukemia.(新規バイオマーカー、可溶型LR11の急性白血病における有用性) (2015)
  • Author(s): 大和田千桂子
  • Organizer: 第77回日本血液学会総会
  • Place of Presentation: ホテル金沢（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Serum sLR11, a novel tumor-derived biomarker in DLBCL: A multicenter prospective analysis. (2015)
  • Author(s): 竹田勇輔
  • Organizer: 第77回日本血液学会総会
  • Place of Presentation: ANAクラウンプラザホテル金沢（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Impact of Serum Soluble LR11 on Survival in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Multicenter Prospective Study (2014)
  • Author(s): Yasumasa Sugita, Chikako Ohwada, et al.
  • Organizer: 第56回 米国血液学会総会 Annual Meeting of American Society of Hematology
  • Place of Presentation: 米国、カルフォルニア州、サンフランシスコ
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] 血管内大細胞性リンパ腫（IVLBCL）の 診断におけるLR11の有用性 (2014)
  • Author(s): 大和田千桂子、中世古知昭、川口岳晴、竹田勇輔 、武内正博1、堺田恵美子 、清水直美 、横手幸太郎
  • Organizer: 第111回日本内科学会総会
  • Place of Presentation: 東京、国際フォーラム
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 血清可溶型LR11（sLR11）のIntravascular large B-cell lymphoma（IVLBCL）に対する診断有用性 (2014)
  • Author(s): 大和田千桂子、中世古知昭、川口岳晴、竹田勇輔、武内正博、堺田惠美子、清水直美、横手幸太郎
  • Organizer: 第111回日本内科学会総会
  • Place of Presentation: 東京
• [Presentation] 濾胞性リンパ腫における可溶型LR11のバイオマーカーとしての有用性 (2013)
  • Author(s): 川口岳晴，大和田千桂子、山崎敦子、塚本祥吉、酒井紫緒、竹田勇輔、武内正博、堺田恵美子、清水直美、横手幸太郎、武城英明、中世古知昭.
  • Organizer: 第50回日本臨床分子医学会学術集会
  • Place of Presentation: 東京