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Biological characteristics of the novel erythropoietin designed to bind to Heparin-like Substances

Research Project

Project/Area Number 25461410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionNiigata University

Principal Investigator

MORIYAMA Masato  新潟大学, 医歯学系, 准教授 (30598131)

Co-Investigator(Kenkyū-buntansha) OZAWA Takuya  新潟大学, 医歯学系, 助教 (70467075)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエリスロポエチン / ヘパリン親和性 / サイトカイン / 造血活性 / 血管増殖阻害 / ヘパリン結合ドメイン / 組織保護 / 細胞外マトリックス
Outline of Final Research Achievements

Erythropoietin (EPO) has been used as an erythropoietic stimulant, and it also shows tissue-protective effects. We synthesized a hybrid molecule of EPO;heparin-binding EPO (HEPO), and studied the characteristics of this novel EPO derivative. Human HEPO (rhHEPO) shows not only long-acting erythropoietic activity, but also antiangiogenic effect. This novel EPO derivative (HEPO) may have an advantage to inhibit tumor growth while preserving hematopoietic and tissue-protective effects.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Book (1 results)

  • [Journal Article] Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation.2016

    • Author(s)
      Nomura S, Maeda Y, Ishii K, Katayama Y, Yagi H, Fujishima N, Ota S, Moriyama M, Ikezoe T, Miyazaki Y, Hayashi K, Fujita S, Satake A, Ito T, Kyo T, Tanimoto M.
    • Journal Title

      J Blood Med.

      Volume: 7 Pages: 1-4

    • DOI

      10.2147/jbm.s93008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible Involvement of Lung Cells Harboring an Abnormal Karyotype in the Pathogenesis of Pulmonary Alveolar Proteinosis Associated with Myelodysplastic Syndrome.2015

    • Author(s)
      Moriyama M, Yano T, Furukawa T, Takada T, Ushiki T, Masuko M, Takizawa J, Sone H, Tazawa R, Saijo Y, Ishii H, Nakata K.
    • Journal Title

      Ann Am Thorac Soc.

      Volume: 8 Pages: 1251-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血栓形成の最初期段階における病態機序の解明とvon Willebrand因子(VWF)関連検査の有用性の検討2014

    • Author(s)
      森山雅人
    • Journal Title

      新潟県医師会報

      Volume: 776 Pages: 8-10

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Book] Erythropoietic Stimulating Agents2013

    • Author(s)
      Ken Toba and Masato Moriyama
    • Total Pages
      10
    • Publisher
      Bentham Science
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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