| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We identified the seventh partner gene of PDGFRA, FOXP1, in a patient with myeloproliferative neoplasm with eosinophilia, harboring the chromosomal abnormality t(3;4)(p13;q12). Platelet counts of CALR-mutated patients tended to be higher
than those of JAK2-mutated patients. However, the occurrence of a thrombotic event was more frequently associated with CALR-mutated patients than with JAK2-mutated patients. The expression of IL-2R alpha on acute myeloid leukemia cells is a poor prognostic factor of acute myeloid leukemia patients ≦ 60 years old. Monocytes in the peripheral blood migrate into the pancreas at least partially through the MCP-1/CCR2 pathway and differentiate into pancreatic stellate cells. When transferred into hosts, tumor antigen-specific T cell receptor gene-engineered T cells retain the ex vivo antigen-specific tumor reactivity to persist for long period.
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