Analysis of pathophysiology of myeloproliferarive neoplasms through the study of their abnormal lymphopoiesis
Project/Area Number |
25461413
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Mie University |
Principal Investigator |
KATAYAMA NAOYUKI 三重大学, 医学(系)研究科(研究院), 教授 (20185812)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | がん幹細胞 / 骨髄増殖性腫瘍 / リンパ球造血 / 本態性血小板血症 / 急性骨髄性白血病 / IL-2R / リンパ球造血造血 |
Outline of Final Research Achievements |
We identified the seventh partner gene of PDGFRA, FOXP1, in a patient with myeloproliferative neoplasm with eosinophilia, harboring the chromosomal abnormality t(3;4)(p13;q12). Platelet counts of CALR-mutated patients tended to be higher than those of JAK2-mutated patients. However, the occurrence of a thrombotic event was more frequently associated with CALR-mutated patients than with JAK2-mutated patients. The expression of IL-2R alpha on acute myeloid leukemia cells is a poor prognostic factor of acute myeloid leukemia patients ≦ 60 years old. Monocytes in the peripheral blood migrate into the pancreas at least partially through the MCP-1/CCR2 pathway and differentiate into pancreatic stellate cells. When transferred into hosts, tumor antigen-specific T cell receptor gene-engineered T cells retain the ex vivo antigen-specific tumor reactivity to persist for long period.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Human equilibrative nucleoside transporter 1 expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy2016
Author(s)
Yamada R, Mizuno S, Uchida K, Yoneda M, Kanayama K, Inoue H, Murata Y, Kuriyama N, Kishiwada M, Usui M, Ii N, Tsuboi J, Tano S, Hamada Y, Tanaka K, Horiki N, Ogura T, Takei Y, Katayama N, Shiraishi T, Isaji S
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Journal Title
Pancreas
Volume: 45
Issue: 5
Pages: 761-771
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fibrin-related markers for diagnosing acute-, subclinical-,and pre-venous thromboembolism in patients with major orthopedic surgery.2016
Author(s)
Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Sudo A.
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Journal Title
Int J Hematol
Volume: 103(5)
Issue: 5
Pages: 560-566
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux2016
Author(s)
Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
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Journal Title
Int J Hematol
Volume: 103
Issue: 5
Pages: 554-559
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Plasma ADAMTS13, von Willebrand Factor (VWF), and VWF propeptide profiles in patients with connective tissue diseases and antiphospholipid syndrome2016
Author(s)
Habe K, Wada H, Matsumoto T, Ohishi K, Ikejiri M, Tsuda K, Kondo M, Kamimoto Y, Ikeda T, Katayama N, Mizutani H
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Journal Title
Clin Appl Thromb Hemost
Volume: 印刷中
Issue: 6
Pages: 622-630
DOI
Related Report
Peer Reviewed
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[Journal Article] Adoptive transfer of MAGE-A4 T-cell receptor gene-transduced lymphocytes in patients with recurrent esophageal cancer2015
Author(s)
Kageyama S, Ikeda H, Miyahara Y, Imai N, Ishihara M, Saito K, Sugino S, Ueda S, Ishikawa T, Kokura S, Naota H, Ohishi K, Shiraishi T, Inoue N, Tanabe M, Kidokoro T, Yoshioka H, Tomura D, Nukaya I, Mineno J, Takesako K, Katayama N, Shiku H.
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Journal Title
Clinical Cancer Research
Volume: in press
Issue: 10
Pages: 2268-2277
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Second and third-look endoscopy for the prevention of post-ESD bleeding2015
Author(s)
Tano S, Horiki N, Omata F, Tanaka K, Hamada Y, Katsurahara M, Ninomiya K, Nishikawa K, Nojiri K, Yamada R, Inoue H, Gabazza EC, Katayama N, Takei Y
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Journal Title
Medicine
Volume: 94
Issue: 6
Pages: e491-e491
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2014
Author(s)
Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
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Journal Title
PLOS ONE
Volume: 9
Issue: 9
Pages: e108494-e108494
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Elevated soluble platelet glycoprotein VI is a useful marker for DVT in postoperative patients treated with edoxaban2014
Author(s)
Aota T, Naitoh K, Wada H, Yamashita Y, Miyamoto N, Hasegawa M, Wakabayashi H, Yoshida K, Asanuma K, Matsumoto T, Ohishi K, Shimokariya Y, Yamada N, Nishikawa M, Katayama N, Uchida A, Sudo A
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Journal Title
Int J Hematol
Volume: 100
Issue: 5
Pages: 450-456
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Analysis of patients with atypical hemolytic uremic syndrome treated at the Mie University Hospital: Concentration of C3 p.I1157T mutation.2014
Author(s)
Matsumoto T, Fan X, Ishikawa E, Ito M, Amano K, Toyoda H, Komada Y, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Fujimura Y, Ikejiri M, Wada H, Miyata T.
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Journal Title
Int J Hematol.
Volume: 100
Issue: 5
Pages: 437-442
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation2014
Author(s)
Takeuchi T, Ino K, Dohi K, Monma F, Nakamori S, Fujieda A, Yamada N, Nakamura M, Masuya M, Katayama N, Ito M
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Journal Title
Int J Cardiol
Volume: 177
Issue: 1
Pages: e22-e24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis2014
Author(s)
Masuya M, Shiraki K, Sugimoto K, Yamamoto N, Yoneda M, Kanayama K, Nishikawa K, Ino K, Tawara I, Ohishi K, Sakurai H, Usui M, Shiraishi T, Isaji S, Takei Y and Katayama N
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Journal Title
Hepatology Research
Volume: 44
Issue: 14
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Elevated Fibrin-related Markers in Patients with Malignant Diseases Frequently Associated with Disseminated Intravascular Coagulation and Venous Thromboembolism2014
Author(s)
Yamashita Y, Wada H, Nomura H, Mizuno T, Saito K, Yamada N, Asanuma K, Usui M, Kamimoto Y, Matsumoto T, Ohishi K, Katayama N
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Journal Title
Internal Medicine
Volume: 53
Issue: 5
Pages: 413-419
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Clinical utility of a panfungal polymerase chain reaction assay for invasive fungal diseases in patients with haematologic disorders.2013
Author(s)
Sugawara Y, Nakase K, Nakamura A, Ohishi K, Sugimoto Y, Fujieda A, Monma F, Suzuki K, Masuya M, Matsushima Y, Wada H, Nobori T, Katayama N.
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Journal Title
Eur J Haematol.
Volume: 90
Issue: 4
Pages: 331-339
DOI
Related Report
Peer Reviewed
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[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013
Author(s)
Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
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Journal Title
Exp Hematol
Volume: -
Issue: 4
Pages: 367-376
DOI
Related Report
Peer Reviewed
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[Journal Article] Septic Arthritis Subsequent to Urosepsis Caused by Hypermucoviscous <i>Klebsiella pneumoniae</i>2013
Author(s)
Suzuki K, Nakamura A, Enokiya T, Iwashita Y, Tomatsu E, Muraki Y, Kaneko T, Okuda M, Katayama N, Imai H
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Journal Title
Internal Medicine
Volume: 52
Issue: 14
Pages: 1641-1645
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Presentation] Adoptive Transfer of WT1-Specific TCR Gene-Transduced Lymphocytes in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia2015
Author(s)
Tawara I, Masuya M, Kageyama S, Nishida T, Terakura S, Murata M, Hiroshi F, Akatsuka Y, Ikeda H, Miyahara Y, Tomura D, Nukaya I, Takesako K, Emi N, Yasukawa M, Katayama N, Shiku H
Organizer
57th ASH Annual Meeting
Place of Presentation
オーランド、アメリカ合衆国
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] Clinical utility of WT1 monitoring after allogeneic hematopoietic stem cell transplantation2015
Author(s)
Kazuko Ino, Shigeo Fuji, Kinuko Tajima, Takashi Tanaka, Keiji Okinaka, Yoshihiro Inamoto , Saiko Kurosawa, Sung-Wom Kim, Takuya Yamashita, Ryuji Tanosaki, Naoyuki Katayama, Takahiro Fukuda
Organizer
第77回日本血液学会学術集会
Place of Presentation
ホテル金沢 (石川県金沢市)
Year and Date
2015-10-16
Related Report
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[Presentation] A phase I clinical trial of adoptive transfer of WT1 redirected T cells for refractory AML and MDS2015
Author(s)
Hiroshi Fujiwara, Isao Tawara, Kazushi Tanimoto, Tetsuya Nishida, Makoto Murata, Seitaro Terakura, Ikuei Nukaya, Yoshiki Akatsuka, Masataka Okamoto, Masahiro Masuya, Hiroaki Ikeda, Sinichi Kageyama, Nobuhiko Emi, Naoyuki Katayama, Masaki Yasukawa, Hiroshi Shiku
Organizer
第77回日本血液学会学術集会
Place of Presentation
ホテル日航金沢 (石川県金沢市)
Year and Date
2015-10-16
Related Report
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[Presentation] Clinical characteristics of cases with essential thrombocythemia harboring CALR and JAK2 mutation2014
Author(s)
Yuka Sugimoto, Makoto Ikejiri, Kohshi Ohishi, Kana Miyazaki, Fumihiko Monma, Satoshi Tamaru, Takeshi Matsumoto, Atsushi Fujieda, Isao Tawara, Motoko Yamaguchi, Masahiro Masuya, Hideo Wada, Masakatsu Nishikawa, Kaname Nakatani, Tsutomu Nobori, Naoyuki Katayama
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] Novel somatic HIF2A mutation in paraganglioma with polycythemia2013
Author(s)
Hirayama J, Toyoda H, Sugimoto Y, Ohishi K, Takekoshi K, Otake K, Inoue M, Uchida K, Nakanishi K, Iwasa T, Iwamoto S, Deguchi T, Hirayama M, Hori H, Azuma E, Kusunoki M, Katayama N, Komada Y
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Related Report
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