Maintenance of CML stem cells through regulation of C/EBPbeta transcription factor

• Project/Area Number: 25461415
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyoto University
• Principal Investigator: Hirai Hideyo 京都大学, 医学(系)研究科(研究院), 助教 (50315933)
• Co-Investigator(Renkei-kenkyūsha): MINAMISHIMA Yoji 慶應義塾大学, 医学部, 講師 (20593966) ; MAEKAWA Taira 京都大学, 医学研究科, 教授 (80229286) ; YOKOTA Asumi 京都大学, 医学研究科, 研究員 (00571556)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 白血病幹細胞 / 低酸素 / 転写因子 / 慢性骨髄性白血病 / C/EBPbeta / サイトカイン / 骨髄微小環境

Outline of Final Research Achievements

In order to achieve complete cure of chronic myeloid leukemia (CML), eradication of CML stem cells (CML-SCs) is cruicial.
In this study, we focused on hypoxic microenvironment and regulation of the transcription factor C/EBPbeta, which is activated by BCR-ABL and promotes differentiation and exhaustion of CML-SCs. Hypoxic condition in vitro reduced the expression of C/EBPbeta in CML cell lines, and cytokine treatment could not reverse this effect. In contrast, when the mice, which had been transplanted with BCA-ABL expressing bone marrow cells, were treated with cytokines, exhaustion of CML-SCs were promoted via upregulation of C/EBPbeta. These results suggest that cytokine treatment may eradicate CML-SCs by remodeling bone marrow microenvironment including hypoxia in addition to direct action on CML-SCs.

Research Products

• [Int'l Joint Research] Harvard Stem Sell Instisute/Cincinnatti Childrens' Hospital(アメリカ)
• [Journal Article] Non-steady-state hematopoiesis regulated by the C/EBPbeta transcription factor. (2015)
  • Author(s): Hirai H, Yokota A, Tamura A, Sato A, Maekawa T.
  • Journal Title: Cancer Science Volume: 106 Pages: 797-802
  • DOI: 10.1111/cas.12690
  • NAID: 120005767014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 464 Pages: 654-658
  • DOI: 10.1016/j.bbrc.2015.07.045
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Isopentenyl Pyrophosphate Secreted from Zoledronate-Stimulated Myeloma Cells, Activates the Chemotaxis of  T Cells (2015)
  • Author(s): Eishi Ashihara, Tatsuya Munaka, Shinya Kimura, Saori Nakagawa, Yoko Nakagawa, Masaki Kanai, Hideyo Hirai, Hirohisa Abe, Takashi Miida, Susumu Yamato, Shuichi Shoji, Taira Maekawa
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 463 Pages: 650-655
  • DOI: 10.1016/j.bbrc.2015.05.118
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system (2015)
  • Author(s): Yoshioka S, #Miura Y, Iwasa M, Fujishiro A, Yao H, Miura M, Fukuoka M, Nakagawa Y, Yokota A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T (#Corresponding author).
  • Journal Title: Int J Hematol. Volume: 102 Pages: 218-229
  • DOI: 10.1007/s12185-015-1828-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CCAAT/enhancer binding protein beta is dispensable for normal and tumor development in lung. (2015)
  • Author(s): Cai Y, Hirata A, Nakayama S, VanderLaan PA, Levantini E, Yamamoto M, Hirai H, Wong KK, Costa DB, Watanabe H, Kobayashi SS
  • Journal Title: Plos ONE Volume: 10
  • DOI: 10.1371/journal.pone.0120647
  • Peer Reviewed / Open Access
• [Journal Article] CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis. (2014)
  • Author(s): Hirai H, Fujishita T, Kurimoto K, Miyachi H, Kitano S, Inamoto S, Itatani Y, Saitou M, Maekawa T, Taketo MM
  • Journal Title: Clinical & Experimental Metastasis Volume: 31 Pages: 977-89
  • DOI: 10.1007/s10585-014-9684-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells (2014)
  • Author(s): Hirai H, et al
  • Journal Title: Stem Cells Volume: 32 Pages: 2245-2255
  • DOI: 10.1002/stem.1701
  • NAID: 40020640317
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 大腸癌におけるSMAD4欠損によりケモカインCCL15が分泌され、CCR1陽性骨髄細胞が集積し、肝転移を促進する (2014)
  • Author(s): 板谷喜朗、河田健二、平位秀世、波多野悦朗、前川平、上本伸二、坂井義治、武藤誠
  • Journal Title: INTESTINE Volume: 18
• [Journal Article] Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. (2014)
  • Author(s): Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T
  • Journal Title: Haematologica Volume: 99(1) Pages: 19-27
  • DOI: 10.3324/haematol.2013.083873
  • Peer Reviewed / Open Access
• [Journal Article] CCAAT/Enhancer-Binding Protein β Expressed by Bone Marrow Mesenchymal Stromal Cells Regulates Early B-Cell Lymphopoiesis. (2014)
  • Author(s): Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A, Maekawa T
  • Journal Title: Stem Cells Volume: 32 Pages: 730-740
  • DOI: 10.1002/stem.1555
  • NAID: 40020640290
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Loss of SMAD4 from colorectal cancer cells promotes CCLl5 expression to recruit CCRl+myeloid cells and facilitate liver metastasis (2013)
  • Author(s): Itatani Y, Kawada K, Fujishita T, Kakizaki F, Hirai H, Matsumoto T, Iwamoto M, Inamoto S, Hatano E, Hasegawa S, Maekawa T, Uemoto S, Sakai Y, Taketo MM
  • Journal Title: Gastroenterol ogy Volume: 145(5) Pages: 1064-1075
  • DOI: 10.1053/j.gastro.2013.07.033
  • NAID: 120005348333
  • Peer Reviewed
• [Journal Article] Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. (2013)
  • Author(s): 1. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y.
  • Journal Title: J. Immunol. Volume: 191 Pages: 1073-1081
  • DOI: 10.4049/jimmunol.1203535
  • Peer Reviewed
• [Journal Article] C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. (2013)
  • Author(s): Hayashi Y, Hirai H, Ashihara E. (他7名)
  • Journal Title: Leukemia Volume: 27 Pages: 619-28
  • DOI: 10.1038/leu.2012.258
  • NAID: 120005466670
  • Peer Reviewed
• [Journal Article] 慢性期CMLと類白血病反応に共通する分子機構 (2013)
  • Author(s): 林 嘉宏、平位秀世、前川 平
  • Journal Title: 血液内科 Volume: 67(5) Pages: 638-645
  • NAID: 40019901724
• [Journal Article] 好中球分化異常と疾患 (2013)
  • Author(s): 平位秀世
  • Journal Title: 臨床血液 Volume: 54(10) Pages: 27-38
  • NAID: 10031196300
• [Presentation] C/EBPβ Isoforms Distinctively and Collaboratively Regulate the Behavior of Hematopoietic Stem and Progenitor Cells in Regenerative Conditions (2015)
  • Author(s): Sato A, Hirai H, Yokota A, Tamura A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] Constitutively-Active ABL Family Kinase, TEL-ARG, Induces Lethal Mastocytosis through Sensitizing Hematopoietic Stem/Progenitor Cells to IL-3. (2015)
  • Author(s): Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] Csf1r Is a Downstream Target of C/EBPβ in Ly6C¯ Monocytes. (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Kashiwagi T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 57th Annual Meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-12-05
  • Int'l Joint Research
• [Presentation] M-CSF receptor is a downstream target of C/EBPβ in Ly6C monocytes development. (2015)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Shoji T, Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-18
• [Presentation] TEL-ARG and TEL-ABL activate distinct differentiation pathways in response to IL-3. (2015)
  • Author(s): Yokota A, Hirai H, Shoji T, Maekawa T, Okuda K
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] C/EBPβ facilitates cell cycle entry of HSPCs in response to hematological stresses. (2015)
  • Author(s): Sato A, Hirai H, Tamura A, Yokota A, Shoji T,Iwasa M, Fujishiro A, Miura Y, Maekawa T
  • Organizer: 第77回日本血液学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] TEL-ABLとTEL-ARGは異なる細胞分化経路を活性化して白血病発症を誘導する. (2015)
  • Author(s): 横田明日美、平位秀世、庄司月美、前川 平、奥田恵子
  • Organizer: 第74回日本癌学会学術総
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-10
• [Presentation] IFNα promotes differentiation of BCR-ABL+ leukemic cells through upregulating C/EBPβ. (2015)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Iwasa M, Fujishiro A, Shoji T, Miura Y, Maekawa T
  • Organizer: International Society for Experimental Hematology, 44th Annual Scientific Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] Essential Roles of C/EBPβ in Survival of Ly6C– monocytes. (2014)
  • Author(s): Akihiro Tamura, Hideyo Hirai, Asumi Yokota, Atsushi Sato, Hisayuki Yao, Masaki Iwasa, Aya Fujishiro, Yasuo Miura and Taira Maekawa
  • Organizer: The 56th ASH Annual Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] C-Terminal Domain of ABL Family Kinases, ABL and ARG, Defines Their Distinct Leukemogenic Activities in Vivo. (2014)
  • Author(s): Asumi Yokota, Hideyo Hirai, Tsukimi Shoji, Taira Maekawa and Keiko Okuda
  • Organizer: The 56th ASH Annual Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] CCR1-Mediated Formation of Liver Microenvironment for Cancer Metastasis. (2014)
  • Author(s): Hideyo Hirai, Teruaki Fujishita, Kazuki Kurimoto, Mitinori Saitou, Taira Maekawa and M Mark Taketo
  • Organizer: The 56th ASH Annual Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Effects of Irradiation on the Functional Characteristics of Human Bone Marrow Mesenchymal Stromal/Stem Cells. (2014)
  • Author(s): Masaki Iwasa, Yasuo Miura, Aya Fujishiro, Akihiro Tamura, Atsushi Sato, Asumi Yokota, Yoko Nakagawa, Satoshi Yoshioka, Hideyo Hirai, Akira Andoh, Tatsuo Ichinohe and Taira Maekawa
  • Organizer: The 56th ASH Annual Meeting
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] C-terminal domain of ABL and ARG kinases defines their distinct leukemogenic activities in mice. (2014)
  • Author(s): Yokota A, Hirai H, Maekawa M, Okuda K
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-11-02
• [Presentation] Effect of irradiation on the characteristics of human bone marrow mesenchymal stromal/stem cells. (2014)
  • Author(s): Iwasa M, Miura Y, Yao H, Yoshioka S, Fujishiro A, Tamura A, Sato A, Yokota A, Hirai H, Ando A, Ichinohe T, Maekawa T
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-11-01
• [Presentation] Isolation of mesenchymal stromal/stem cells from UCB ineligible for public UCB donation. (2014)
  • Author(s): Yoshioka S, Miura Y, Yao H, Iwasa M, Fujishiro A, Higashi Y, Yokota A, Tamura A, Sato A, Hirai H, Ichinohe T, Takaori-Kondo A, Maekawa T
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-11-01
• [Presentation] C/EBPβpromotes initial expansion and exhaustion of hematopoietic stem cells in response to stresses. (2014)
  • Author(s): Sato A, Hirai H, Tamura A, Yokota A, Hayashi Y, Yao H, Yoshiioka S, Iwasa M, Miura Y, Maekawa T
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-10-31
• [Presentation] Critical roles of C/EBP β for survival of Ly6C-Monocytes. (2014)
  • Author(s): Tamura A, Hirai H, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Miura Y, Ashihara E, Maekawa T
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-10-31
• [Presentation] Involvement of C/EBP β in IFN α-induced differentiation of BCR-ABL-expressing leukemic cells. (2014)
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H,Yoshioka S, Iwasa M, Miura Y, Maekawa T
  • Organizer: 第７６回日本血液学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2014-10-31
• [Presentation] BCR-ABL発現白血病細胞に対するC/EBPβを介したIFNαの作用. (2014)
  • Author(s): 横田明日美、平位秀世、林 嘉宏、田村彰広、佐藤淳至、八尾尚幸、岩佐麿佐紀、藤城 綾、三浦康生、前川 平
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2014-09-26
• [Presentation] さい帯血バンク保存基準に満たない小容量さい帯血ユニットを利用した間葉系幹細胞樹立の試み (2014)
  • Author(s): 吉岡聡、三浦康生、八尾尚幸、岩佐磨佐紀、藤城綾、東弥生、田村彰広、佐藤淳至、横田明日美、平位秀世、一戸辰夫、高折晃史、前川平
  • Organizer: 第23回日本組織適合性学会
  • Place of Presentation: 長崎大学坂本キャンパス(長崎)
  • Year and Date: 2014-09-15
• [Presentation] 抗ドナー抗体（DSA）陽性で高度な移植肝繊維化の進行を認めた症例に対して免疫抑制療法強化でDSAが陰性化し線維化が改善した1例. (2014)
  • Author(s): 平田義弘、吉澤淳、上田大輔、菱田理恵、万木紀美子、平位秀世、宮川文、小川絵里、安井良僚、園田真理、岡島英明、海道利実、前川平、羽賀博典、上本伸二
  • Organizer: 第23回日本組織適合性学会
  • Place of Presentation: 長崎大学坂本キャンパス(長崎)
  • Year and Date: 2014-09-15
• [Presentation] 骨髄移植症例におけるドナー由来HLA抗体への対応 (2014)
  • Author(s): 万木紀美子、三浦康生、菱田理恵、平位秀世、北脇年雄、錦織桃子、菱澤方勝、近藤忠一、北野俊行、高折晃史、前川平
  • Organizer: 第62回日本輸血・細胞治療学会総会
  • Place of Presentation: 奈良文化会館(奈良)
  • Year and Date: 2014-05-16
• [Presentation] さい帯血バンク保存基準に満たない少容量さい帯血ユニットを利用した間葉系幹細胞樹立の試み (2014)
  • Author(s): 吉岡聡、三浦康生、八尾尚幸、岩佐磨佐紀、藤城綾、東弥生、田村彰広、佐藤淳至、横田明日美、平位秀世、一戸辰夫、高折晃史、前川平
  • Organizer: 第22回近畿臍帯血幹細胞移植研究会
  • Place of Presentation: ホテルグランヴィア大阪(大阪)
  • Year and Date: 2014-05-10
• [Presentation] 間葉系幹細胞と副甲状腺ホルモンを応用した造血細胞の増幅
  • Author(s): 三浦康生、八尾尚幸、吉岡 聡、岩佐磨佐紀、田村彰広、佐藤 淳、横田明日美、平位秀世、一戸辰夫、前川 平
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄
• [Presentation] Parathyroid hormone enhances expansion through CDH11 in human bone marrow mesenchymal stromal/stem cells.
  • Author(s): Yao H, Miura Y, Yoshioka S, Hayashi Y, Yokota A, Tamura A, Ichinohe T, Hirai H and Maekawa T
  • Organizer: AsiaCORD 2013
  • Place of Presentation: 神戸
• [Presentation] C/EBPβ in mesenchymal stromal/stem cells regulates early B cell lymphopoiesis.
  • Author(s): Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaori-Kondo A and Maekawa T
  • Organizer: AsiaCORD 2013
  • Place of Presentation: 神戸
• [Presentation] Protective roles of myeloid-derived suppressor cells in autoimmune arthritis murine models through inhibiting pro-inflammatory immune response of CD4+ T cell.
  • Author(s): Fujii W, Nagahara H, Kajitani N, Fujioka K, Murakami K, Nakamura K, Seno T, Yamamoto A, Ishino H, Kohno M, Kawahito Y
  • Organizer: The 57th Annual General Assemble and Scientific Meeting of the Japan Collage of Rheumatology
  • Place of Presentation: 京都
• [Presentation] Myeloid-derived suppressor cells have regulatory roles in mouse collagen-induced arthritis.
  • Author(s): Fujii W, Ashihara E, Hirai H, Nagahara H, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Madrid, Spain
• [Presentation] C/EBPβ expressed by bone marrow mesenchymal stromal cells is indispensable for precursor B-cell lymphopoiesis.
  • Author(s): Yoshioka S, Miura Y, Yao H, Iwasa M, Sato A, Tamura A, Yokota A, Hishita T, Ichinohe T, Hirai H, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Cytokine-STATs signalings upregulate endogenous C/EBPβ in BCR-ABL+ leukemic cells independently from BCR-ABL signaling.
  • Author(s): Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA, December 7, 2013
• [Presentation] Cell-intrinsic and -extrinsic involvement of C/EBPβ in the regulation of hematopoietic stem cells.
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Hypoxia-Adapted Myeloma Cells Possess Stem Cell Character.
  • Author(s): Ashihara E, Nakagawa Y, Yao H, Yokota A, Miura Y, Takata K, Kitamura Y, Hirai H , Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Direct Interaction with Bone Marrow Mesenchymal Stromal/Stem Cells Is Required for Hematopoietic Expansion by Parathyroid Hormone.
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Tamura A, Yokota A, Ashihara E, Ichinohe T, Hirai H,Maekawa T
  • Organizer: American Society of Hematology, 55th Annual Meeting
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] 好中球分化異常と疾患. (教育講演５)
  • Author(s): 平位秀世
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌
• [Presentation] 胆汁性肝硬変患者が保有するHLA抗体について
  • Author(s): 万木紀美子、平位秀世、菱田理恵、吉澤 淳、吉岡 聡、三浦康生、芦原英司、上本伸二、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 接着法による効率的なさい帯血からの間葉系幹細胞分離に関する検討
  • Author(s): 吉岡聡，三浦康生，万木紀美子，平位秀世，東 弥生，高折晃史，前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] 高頻度抗原に対する不規則抗体および複合抗体陽性の肝臓移植症例への対応 ― 院内および血液センターとの連携の重要性 ―
  • Author(s): 万木紀美子、平位秀世、藤本康弘、河村朋子、樋口征昭、丹羽紀美、竹川良子、菱田理恵、三浦康生、辻 肇、上本伸二、前川 平
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: 横浜
• [Presentation] C/EBPbはカンジダ感染後の造血幹細胞・骨髄系前駆細胞の増殖を制御する
  • Author(s): 田村彰広、平位秀世、佐竹早紀子、志馬伸朗、佐和貞治
  • Organizer: 第87回日本感染症学会
  • Place of Presentation: 横浜
• [Presentation] 転写因子C/EBPβは骨髄系分化・増殖の誘導によりCML幹細胞を減少させる
  • Author(s): 林 嘉宏、平位秀世、横田明日美、八尾尚幸、三浦康生、芦原英司、前川 平
  • Organizer: 第17回日本がん分子標的治療学会学術総会
  • Place of Presentation: 京都
• [Presentation] コラーゲン誘導関節炎におけるMyeloid-derived suppressor cellsは関節炎の制御に重要な役割を果たす
  • Author(s): 藤井渉、芦原英司、平位秀世、村上憲、妹尾高宏、山本相浩、石野秀岳、河野正孝、前川平、川人豊
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 京都
• [Presentation] Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs.
  • Author(s): Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Hayashi Y, Tamura A, Yokota A, Ichinohe T, Tohyama K, Hirai H, Maekawa T
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 札幌
• [Presentation] Involvement of C/EBPβ in the regulation of hematopoietic stem cells.
  • Author(s): Tamura A, Hirai H, Hayashi Y, Yokota A, Yao H, Yoshioka S, Sato A, Iwasa M, Ashihara E, Miura Y, and Maekawa T
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 札幌
• [Presentation] 高頻度抗原に対する不規則抗体（抗Jra抗体）の抗体価推移の検討
  • Author(s): 万木紀美子、平位秀世、藤本康弘、丹羽紀実、竹川良子、菱田理恵、三浦康生、上本伸二、前川平
  • Organizer: 第75回日本血液学会総会
  • Place of Presentation: 札幌
• [Presentation] 骨髄移植症例におけるドナー由来HLA抗体への対応
  • Author(s): 万木紀美子、三浦康生、菱田理恵、北脇年雄、錦織桃子、菱澤方勝、近藤忠一、北野俊行、芦原英司、高折晃史、平位秀世、前川平
  • Organizer: 第100回近畿血液学地方会
  • Place of Presentation: 大阪
• [Presentation] Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis.
  • Author(s): Fujii W, Ashihara E, Hirai H, Fujioka K, Seno T, Ishino H, Kawahito Y
  • Organizer: Annual Meeting of the Japanease Society for Immunology
  • Place of Presentation: 千葉
• [Remarks] 京都大学医学部附属病院・輸血細胞治療部
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/
• [Remarks] 京都大学医学部付属病院・輸血細胞治療部ホームページ
  • URL: http://dtm.kuhp.kyoto-u.ac.jp/