Elucidating common oncogenic pathway and generating anti-cancer agents
Project/Area Number |
25461420
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kyoto University |
Principal Investigator |
Kamikubo Yasuhiko 京都大学, 医学(系)研究科(研究院), 准教授 (60548527)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 白血病 / 低分子化合物 / 転写因子創薬 / 担癌マウスモデル / 肺癌 / 胃癌 / 遺伝子発現制御 / 癌増殖機構 / レセプターチロシンキナーゼ / シグナル伝達 / 転写因子 / CBF白血病 / MLL白血病 / BCR-ABL白血病 / APL白血病 / バーキットリンパ腫 / シュミレーション創薬 / DDSナノテクノロジー / エピジェネティック制御 / RUNX1 / HIF2 / NFκB / PML / Inv16白血病 |
Outline of Final Research Achievements |
I have elucidated that transcription factorA and its co-factorB are required for almost all leukemogenesis.It is quite important findings to isolate one of the best targets for leukemia therapy.I have generated novel anti-leukemia drugs D which extend the life spans of mice models such as PhALL(T315I)and MLL-AF4+FLT3-ITD dramatically, suggesting the transcription facorA is novel pro-oncogenic factor for leukemogenesis.On the other hand, Solid tumores such as EGFR Inhibitor resistant NSCLC, Her2 positive gastric cancer, neuroblastoma were also down-regulated by drug D in xeno-grafted mice models.We have already isolated several small molecules(HITS) through Super-computional simulation(MD)
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015
Author(s)
Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
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Journal Title
Leukemia
Volume: 29
Issue: 12
Pages: 2438-2441
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against multi-drug-resistant bacteria as well as drug sensitive strains.2015
Author(s)
Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, Kamikubo Y, Kondo T, Yamashita K, Sasada M, Takaori-Kondo A, Adachi S.
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Journal Title
Journal of Leukocyte Biology
Volume: 98
Issue: 1
Pages: 107-117
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against multi-drug-resistant bacteria as same as drug sensitive strains2015
Author(s)
Hiroshi Itoh, Hidemasa Matsuo, Naoko Kitamura, Sho Yamamoto, Takeshi Higuchi, Hiromu Takematsu, Yasuhiko Kamikubo, Tadakazu Kondo, Kouhei Yamashita, Masataka Sasada§, Akifumi Takaori-Kondo, Souichi Adachi
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Journal Title
Journal of Leukocyte Biology
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Adverse Prognostic Impact of KIT Mutations in Childhood CBF-AML: the Results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 Trial2015
Author(s)
Mayu Tokumasu, Chisato Kubota-Murata, Akira Shimada, Kentaro Ohki, Yasuhide Hayashi, Akiko Saito, Junichiro Fujimoto, Keizo Horibe, Miho Nagao, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Shiro Tanaka, Toshio Heike, and Souichi Adachi
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples2014
Author(s)
Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M
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Journal Title
Exp Hematol
Volume: (in press)
Issue: 9
Pages: 816-25
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prognostic significance of CXCR4 overexpressio in pediatric AML : the JPLSG AML-05 study2015
Author(s)
Hidemasa Matsuo, Naomi Nakamura, Daisuke Tomizawa, Tomoyuki Watanabe, Akiko Moriya Saito, Jun-Ichiro Fujimoto, Keizo Horibe, Yoko Nichinak, Mayu Tokumasu, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Takashi Taga, Akio Tawa, Tomohiko Taki, ※Souichi Adachi
Organizer
第77回日本血液学会総会
Place of Presentation
金沢
Year and Date
2015-10-16
Related Report
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