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Elucidating common oncogenic pathway and generating anti-cancer agents

Research Project

Project/Area Number 25461420
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKyoto University

Principal Investigator

Kamikubo Yasuhiko  京都大学, 医学(系)研究科(研究院), 准教授 (60548527)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords白血病 / 低分子化合物 / 転写因子創薬 / 担癌マウスモデル / 肺癌 / 胃癌 / 遺伝子発現制御 / 癌増殖機構 / レセプターチロシンキナーゼ / シグナル伝達 / 転写因子 / CBF白血病 / MLL白血病 / BCR-ABL白血病 / APL白血病 / バーキットリンパ腫 / シュミレーション創薬 / DDSナノテクノロジー / エピジェネティック制御 / RUNX1 / HIF2 / NFκB / PML / Inv16白血病
Outline of Final Research Achievements

I have elucidated that transcription factorA and its co-factorB are required for almost all leukemogenesis.It is quite important findings to isolate one of the best targets for leukemia therapy.I have generated novel anti-leukemia drugs D which extend the life spans of mice models such as PhALL(T315I)and MLL-AF4+FLT3-ITD dramatically, suggesting the transcription facorA is novel pro-oncogenic factor for leukemogenesis.On the other hand, Solid tumores such as EGFR Inhibitor resistant NSCLC, Her2 positive gastric cancer, neuroblastoma were also down-regulated by drug D in xeno-grafted mice models.We have already isolated several small molecules(HITS) through Super-computional simulation(MD)

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (35 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (11 results) (of which Invited: 5 results) Book (1 results) Remarks (8 results)

  • [Journal Article] Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial.2015

    • Author(s)
      Tokumasu M, Murata C, Shimada A, Ohki K, Hayashi Y, Saito AM, Fujimoto J, Horibe K, Nagao M, Itoh H, Kamikubo Y, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Tawa A, Tanaka S, Heike T, Adachi S
    • Journal Title

      Leukemia

      Volume: 29 Issue: 12 Pages: 2438-2441

    • DOI

      10.1038/leu.2015.121

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intravenous immunoglobulin enhances the killing activity and autophagy of neutrophils isolated from immunocompromised patients against multidrug-resistant bacteria.2015

    • Author(s)
      Matsuo H, Itoh H, Kitamura N, Kamikubo Y, Higuchi T, Shiga S, Ichiyama S, Kondo T, Takaori-Kondo A, Adachi S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 464 Issue: 1 Pages: 94-9

    • DOI

      10.1016/j.bbrc.2015.06.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against multi-drug-resistant bacteria as well as drug sensitive strains.2015

    • Author(s)
      Itoh H, Matsuo H, Kitamura N, Yamamoto S, Higuchi T, Takematsu H, Kamikubo Y, Kondo T, Yamashita K, Sasada M, Takaori-Kondo A, Adachi S.
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 98 Issue: 1 Pages: 107-117

    • DOI

      10.1189/jlb.4a0813-422rrr

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.2015

    • Author(s)
      Matsuo H, Goyama S, Kamikubo Y, Adachi S
    • Journal Title

      Haematologica.

      Volume: 100

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhancement of neutrophil autophagy by an IVIG preparation against multi-drug-resistant bacteria as same as drug sensitive strains2015

    • Author(s)
      Hiroshi Itoh, Hidemasa Matsuo, Naoko Kitamura, Sho Yamamoto, Takeshi Higuchi, Hiromu Takematsu, Yasuhiko Kamikubo, Tadakazu Kondo, Kouhei Yamashita, Masataka Sasada§, Akifumi Takaori-Kondo, Souichi Adachi
    • Journal Title

      Journal of Leukocyte Biology

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adverse Prognostic Impact of KIT Mutations in Childhood CBF-AML: the Results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 Trial2015

    • Author(s)
      Mayu Tokumasu, Chisato Kubota-Murata, Akira Shimada, Kentaro Ohki, Yasuhide Hayashi, Akiko Saito, Junichiro Fujimoto, Keizo Horibe, Miho Nagao, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Shiro Tanaka, Toshio Heike, and Souichi Adachi
    • Journal Title

      Leukemia

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia.2015

    • Author(s)
      Matsuo H, Goyama S, Kamikubo Y, Adachi S
    • Journal Title

      Haematologica

      Volume: 100(3) Issue: 3 Pages: 116-117

    • DOI

      10.3324/haematol.2015.124396

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of induced pluripotent stem cells derived from primary and secondary myelofibrosis patient samples2014

    • Author(s)
      Hosoi M, Kumano K, Taoka K, Arai S, Kataoka K, Ueda K, Kamikubo Y, Takayama N, Otsu M, Eto K, Nakauchi H, Kurokawa M
    • Journal Title

      Exp Hematol

      Volume: (in press) Issue: 9 Pages: 816-25

    • DOI

      10.1016/j.exphem.2014.03.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catheter-related septic shock by Micrococcus in an autologous hematopoietic stem cell transplantation recipient2013

    • Author(s)
      Kogure Y, Nakamura F, Nukina A, Kamikubo Y, Ichikawa M, Kurokawa M, Kamikubo Y, Kurokawa M
    • Journal Title

      Am J Infect Control.

      Volume: 42 Issue: 1 Pages: 87-87

    • DOI

      10.1016/j.ajic.2013.07.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] HIV-associated Burkitt lymphoma in a Japanese patient with early submandibular swelling.2013

    • Author(s)
      Komatsu N, Kawase-Koga Y, Mori Y, Kamikubo Y, Kurokawa M, Takato T.
    • Journal Title

      BMC Res Notes

      Volume: 6 Issue: 1 Pages: 557-557

    • DOI

      10.1186/1756-0500-6-557

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of CD20-positive peripheral T-cell lymphoma treated with rituximab and multiagent chemotherapy2013

    • Author(s)
      Kamata M, Sugaya M, Miyagaki T, Sonoda K, Ichimura Y, Mitsui H, Sato S, Kamikubo Y, Kurokawa M.
    • Journal Title

      Int J Dermatol 2013

      Volume: 53 Issue: 1 Pages: 1365-1366

    • DOI

      10.1111/j.1365-4632.2012.05483.x

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/research_d.html

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D.2013

    • Author(s)
      Kobayashi T, Ichikawa M, Kamikubo Y, Kurokawa M.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 6 Pages: 110-112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects andleukemogenesis.2013

    • Author(s)
      Kamikubo Y, Hyde RK, Zhao L, Alemu L, Rivas C, Garrett LJ, Liu PP.
    • Journal Title

      Blood 2013

      Volume: 24 Issue: 4 Pages: 638-42

    • DOI

      10.1182/blood-2012-06-434688

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy2013

    • Author(s)
      Sho Hangai
    • Journal Title

      Annals of Hematology

      Volume: 92 Issue: 5 Pages: 707-709

    • DOI

      10.1007/s00277-012-1603-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation2012

    • Author(s)
      Sho Hangai
    • Journal Title

      Annals of Hematology

      Volume: December12 Issue: 7 Pages: 1654-1655

    • DOI

      10.1007/s00277-012-1654-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 難治性白血病に対する新たな耐性克服戦略2016

    • Author(s)
      上久保靖彦
    • Organizer
      第105回近畿血液学地方会
    • Place of Presentation
      兵庫県
    • Year and Date
      2016-06-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] スパコンシミュレーション創薬による革新的抗がん剤開発2016

    • Author(s)
      上久保靖彦
    • Organizer
      京都大学メディカルイノベーションセンターセミナー
    • Place of Presentation
      京都
    • Year and Date
      2016-04-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Prognostic significance of CXCR4 overexpressio in pediatric AML : the JPLSG AML-05 study2015

    • Author(s)
      Hidemasa Matsuo, Naomi Nakamura, Daisuke Tomizawa, Tomoyuki Watanabe, Akiko Moriya Saito, Jun-Ichiro Fujimoto, Keizo Horibe, Yoko Nichinak, Mayu Tokumasu, Hiroshi Itoh, Yasuhiko Kamikubo, Hideki Nakayama, Akitoshi Kinoshita, Takashi Taga, Akio Tawa, Tomohiko Taki, ※Souichi Adachi
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] The mechanism and the effct of p300 inhibitor on MLL-rearranged ALL cells2015

    • Author(s)
      Ayaka Ikeuchi, Yasuhiko Kamikubo, Masumi Mori, Yui Noji, Hiroshi Itoh, Souichi Adachi :
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Induction of cell cycle arrest and apoptosis in ph+ALL cells through inhibition of p3002015

    • Author(s)
      Masumi Mori, Yasuhiko Kamikubo, Ayaka Ikeuchi, Yui Noji, Hiroshi Ito, Souichi Adachi
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] エピジェネティック創薬による白血病克服戦略の構築2015

    • Author(s)
      上久保靖彦
    • Organizer
      京滋血液研究会
    • Place of Presentation
      京都
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] がん・成人病への挑戦:各種癌共通増殖機構の解明及びそれをターゲットとした新規エピジェネティック創薬2015

    • Author(s)
      上久保靖彦
    • Organizer
      京滋血液研究会
    • Place of Presentation
      公益財団法人HLA研究所 京都
    • Year and Date
      2015-04-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] エピジェネティック制御による遺伝子変異阻害メカニズムの解明と難治性急性骨髄性白血病個別化治療法の開発2015

    • Author(s)
      野路 由依 矢野 礼佳 上久保 靖彦 足立 壮一
    • Organizer
      第29回京都がん研究会
    • Place of Presentation
      京都教育文化センター 2F ホール 京都
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児がんへの挑戦:夢の創薬 日米~アジア小児がん学術ネットワークの創生2015

    • Author(s)
      上久保靖彦
    • Organizer
      第20回西日本小児がんセミナー
    • Place of Presentation
      大阪リーガロイヤルホテル 大阪
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 腫瘍抑制因子の逆説的要求性:新規白血病診療・治療戦略2015

    • Author(s)
      上久保靖彦
    • Organizer
      第33回京都大学小児血液腫瘍研究会
    • Place of Presentation
      京都タワーホテル 京都
    • Year and Date
      2015-02-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 白血病リンパ腫共通増殖機構解明の試み及び新規治療薬開発2013

    • Author(s)
      上久保靖彦
    • Organizer
      兵庫県白血病懇話会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 日本小児血液・がん学会雑誌2015

    • Author(s)
      上久保靖彦
    • Total Pages
      8
    • Publisher
      中西印刷株式会社
    • Related Report
      2014 Research-status Report
  • [Remarks] 癌創薬イノベーション研究室 | 京都大学大学院医学研究科・医学部

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0303/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 血液・生体防御学研究室

    • URL

      http://adachilab.web.fc2.com/paper.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都大学大学院医学研究科人間健康科学専攻 癌・創薬イノベーション研究室

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0303/

    • Related Report
      2014 Research-status Report
  • [Remarks] Laboratory of Oncology and Strategic Innovation

    • URL

      http://www.med.kyoto-u.ac.jp/en/organization-staff/research/human_health/mt0303/

    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学医学部人間健康科学科検査技術科学専攻血液・生体防御学研究室

    • URL

      http://adachilab.web.fc2.com/member.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪大学大学院医学系研究科遺伝子治療学

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/research_d.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学大学院医学研究科人間健康科学専攻 癌・創薬イノベーション研究室

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/human_health/mt0303/

    • Related Report
      2013 Research-status Report
  • [Remarks] 大阪大学大学院医学系研究科遺伝子治療学

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/research_d.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2023-01-30  

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