The clalification of the mechanism of B-cell lymphoma progression with post-transcriptional factor, TFL.

Research Project

Project/Area Number	25461421
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Hematology
Research Institution	Kobe University
Principal Investigator	Minagawa Kentaro 神戸大学, 医学(系)研究科(研究院), 研究員 (80432574)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	ＴＦＬ / 転写後調節 / リンパ腫 / ｍＲＮＡ / 予後予測 / サイトカイン / ＲＮＡ調節 / 転写後調節分子
Outline of Final Research Achievements	We found the post-transcriptional factor, TFL, from a lymphoma patient. TFL modulates many cytokines after inflammation to localize its inflammatory effect. We found TFL deficient mice are prone to have worse prognosis in lymphoma induced mice. Further we found a certain molecule was abnormally controlled without TFL. In clinical setting, the deficit of TFL are worse prognosis in diffuse large B-cell lymphoma. It is of interest whether TFL would be the reliable and effective prognosis marker for B-cell lymphoma.