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The clalification of the mechanism of B-cell lymphoma progression with post-transcriptional factor, TFL.

Research Project

Project/Area Number 25461421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionKobe University

Principal Investigator

Minagawa Kentaro  神戸大学, 医学(系)研究科(研究院), 研究員 (80432574)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsTFL / 転写後調節 / リンパ腫 / mRNA / 予後予測 / サイトカイン / RNA調節 / 転写後調節分子
Outline of Final Research Achievements

We found the post-transcriptional factor, TFL, from a lymphoma patient. TFL modulates many cytokines after inflammation to localize its inflammatory effect. We found TFL deficient mice are prone to have worse prognosis in lymphoma induced mice. Further we found a certain molecule was abnormally controlled without TFL. In clinical setting, the deficit of TFL are worse prognosis in diffuse large B-cell lymphoma. It is of interest whether TFL would be the reliable and effective prognosis marker for B-cell lymphoma.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Remarks (2 results)

  • [Journal Article] TFL, a hidden post-transcriptional modulator behind inflammation2014

    • Author(s)
      Kentaro Minagawa, Yoshio Katayama, Toshimitsu Matsui
    • Journal Title

      Inflammation & Cell Signaling

      Volume: 1: e244 Pages: 1-7

    • DOI

      10.14800/ics.244

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.2014

    • Author(s)
      Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T.
    • Journal Title

      J Immunol.

      Volume: 192(4) Issue: 4 Pages: 1512-1524

    • DOI

      10.4049/jimmunol.1301619

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Remarks] 新規がん抑制遺伝子 TFL による 悪性リンパ腫診断と予後予測

    • Related Report
      2014 Research-status Report
  • [Remarks] 神戸大学医学部血液内科HP

    • URL

      http://www.med.kobe-u.ac.jp/im3/rinsyo/ketueki/research2.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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