Molecular mechanisms of radiation-associated myelodysplastic syndromes (MDS)

• Project/Area Number: 25461422
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Bunkyo Gakuin University (2015); Juntendo University (2013-2014)
• Principal Investigator: HARADA Yuka 文京学院大学, 保健医療学部, 教授 (50379848)
• Co-Investigator(Kenkyū-buntansha): HARADA Hironori 順天堂大学, 医学部, 准教授 (10314775)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 低線量被曝 / RUNX1変異 / 骨髄異形成症候群 / 骨髄異形成／骨髄増殖性腫瘍 / 慢性骨髄単球性白血病 / スプライシング因子変異 / 放射線傷害耐性 / BMI1

Outline of Final Research Achievements

We analyzed gene mutations in patients with myeloid neoplasms mainly myelodysplastic syndromes (MDS) including atomic bomb survivors in Hiroshima. Low dose radiation-associated MDS patients showed slightly higher frequency of RUNX1 mutations than the patients within 2 km from hypocenter. Especially, both of 2 patients exposed to “black rain”, which contains radioactive fallout just after atomic bomb in Hiroshima, developed chronic myelomonocytic leukemia (CMML) with RUNX1 mutations. Therefore, we investigated gene abnormalities in CMML patients and found high frequency of RUNX1 mutations. Furthermore, high expression of RUNX1 short isoform (RUNX1a) was associated with mutations of splicesome factors which were frequently found in CMML. It is suspected that RUNX1 mutations may be induced by low dose radiation. In addition, hematopoietic stem cells with RUNX1 mutations may have resistance to irradiation and proliferate after radiation injury.

Research Products

• [Journal Article] Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele (2016)
  • Author(s): Sakurai M, Kasahara H, Yoshida K, Yoshimi A, Kunimoto H, Watanabe N, Shiraishi Y, Chiba K, Tanaka H, Harada Y, Harada H, Kawakita T, Kurokawa M, Miyano S, Takahashi S, Ogawa S, Okamoto S, Nakajima H
  • Journal Title: Blood Cancer J Volume: 6 Issue: 2 Pages: e392-e392
  • DOI: 10.1038/bcj.2015.81
  • Peer Reviewed / Open Access
• [Journal Article] Spectrum of clinical and genetic features of patients with inherited platelet disorder with suspected predisposition to hematological malignancies: a nationwide survey in Japan. (2016)
  • Author(s): Yoshimi A, Toya T, Nannya Y, Takaoka K, Kirito K, Ito E, Nakajima H, Hayashi Y, Takahashi T, moriya-Saito A, Suzuki K, Harada H, Komatsu N, Usuki K, Ixhikawa M, Kurokawa M.
  • Journal Title: Annals of Oncology Volume: 27 Issue: 5 Pages: 887-895
  • DOI: 10.1093/annonc/mdw066
  • Peer Reviewed / Open Access
• [Journal Article] Chronic myelomonocytic leukemia (CMML): recent advances in molecular pathogenesis and treatment (2016)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: Rinsho Ketsueki Volume: 57 Issue: 2 Pages: 147-155
  • DOI: 10.11406/rinketsu.57.147
  • NAID: 130005132713
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Recent advances in myelodysplastic syndromes: molecular pathogenesis and its implications for targeted therapies (2015)
  • Author(s): Harada H, Harada Y
  • Journal Title: Cancer Sci. Volume: 106 Issue: 4 Pages: 329-336
  • DOI: 10.1111/cas.12614
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-C(m)) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-C(m). (2015)
  • Author(s): Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T.
  • Journal Title: Exp Hematol. Volume: 43(4) Issue: 4 Pages: 300-308
  • DOI: 10.1016/j.exphem.2014.11.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. (2015)
  • Author(s): Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T.
  • Journal Title: Leukemia Volume: 29(4) Issue: 4 Pages: 847-57
  • DOI: 10.1038/leu.2014.301
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression (2015)
  • Author(s): Hirano Tetsuo, Yoshikawa Ryoko, Harada Hironori, Harada Yuka, Ishida Atsuhiko, Yamazaki Takeshi
  • Journal Title: Molecular Cancer Volume: 14 Issue: 1 Pages: 90-104
  • DOI: 10.1186/s12943-015-0364-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A randomized controlled trial comparing darbepoetin alfa doses in red blood cell transfusion-dependent patients with low- or intermediate-1 risk myelodysplastic syndromes (2015)
  • Author(s): Jang JH, Harada H, Shibayama H, Shimazaki R, Kim HJ, Sawada K, Mitani K
  • Journal Title: Int J Hematol Volume: 102(4) Issue: 4 Pages: 401-412
  • DOI: 10.1007/s12185-015-1862-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 白血病の発症機序と分子標的治療 (2015)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 臨床雑誌「内科」 Volume: 116(2) Pages: 191-197
• [Journal Article] 【骨髄異形成症候群（MDS）－最近の進歩－】 基礎：MDSの分子病態 (2015)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 最新医学 Volume: 70(11) Pages: 2069-2075
• [Journal Article] 【特集：血液内科診療の展望】 骨髄異形成症候群診療の展望 (2015)
  • Author(s): 原田浩徳
  • Journal Title: 日医大医会誌 Volume: 11(4) Pages: 187-191
• [Journal Article] 【特集：急性骨髄性白血病のゲノム解析～現状と展望～】 Germline変異と急性骨髄性白血病 (2015)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液フロンティア Volume: 25(11) Pages: 1607-1615
• [Journal Article] 【特集／骨髄異形成症候群（MDS）の病態解析と治療の進歩】 メチル化阻害薬の効果予測とゲノム解析 (2015)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液内科 Volume: 71(5) Pages: 593-599
• [Journal Article] Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice (2014)
  • Author(s): Lam K, Muselman A, Du R, Harada Y, Scholl AG, Yan M, Matsuura S, Weng S, Harada H, Zhang DE
  • Journal Title: Blood Volume: 124 Issue: 14 Pages: 2203-2212
  • DOI: 10.1182/blood-2014-02-554543
  • Peer Reviewed / Open Access
• [Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. (2014)
  • Author(s): Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
  • Journal Title: Blood Volume: 123(25) Issue: 25 Pages: 3932-42
  • DOI: 10.1182/blood-2013-01-476747
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients (2014)
  • Author(s): Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H
  • Journal Title: Leukemia Volume: 28 Issue: 12 Pages: 2344-54
  • DOI: 10.1038/leu.2014.136
  • Peer Reviewed / Open Access
• [Journal Article] Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukemic transformation. (2014)
  • Author(s): Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayasi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 5177-5177
  • DOI: 10.1038/ncomms5177
  • Peer Reviewed / Open Access
• [Journal Article] Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. (2014)
  • Author(s): Uchida T, Kawabata KC, Kitamura T., et al.
  • Journal Title: Exp Hematol. Volume: S0301-472X(14) Issue: 5 Pages: 56-3
  • DOI: 10.1016/j.exphem.2014.01.009
  • Peer Reviewed / Open Access
• [Journal Article] 広島で近距離被爆後に長期間を経て白血病を発症した母娘例 (2014)
  • Author(s): 岡田浩佑，鎌田七男，藤村欣吾，河村 寛，中井志郎，田中公夫，小熊信夫，許 泰一，岩戸康司，板垣充弘，宮原弥恵，新谷貴洋，原田浩徳，佐々木英夫
  • Journal Title: 広島医学 Volume: 67(4) Pages: 396-400
• [Journal Article] ばく関連資料データベース(新聞記事)のテキスト解析の試み (2014)
  • Author(s): 佐藤裕哉，佐藤健一，原田結花，嶋本浩子，原憲行，原田浩徳，大瀧 慈，田代 聡
  • Journal Title: 広島医学 Volume: 67(4) Pages: 406-409
• [Journal Article] 【血液疾患とクローン性】 造血器腫瘍のクローン性進展 骨髄異形成症候群の病型悪化とクローン性進展 (2014)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液フロンティア Volume: 24(6) Pages: 895-902
• [Journal Article] 【赤血球造血と疾患をめぐる最近の進歩】 MDSに対する薬物療法の進歩 (2014)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液内科 Volume: 68(5) Pages: 616-623
• [Journal Article] 骨髄異形成症候群におけるRUNX1変異とBMI1過剰発現の協調作用 (2014)
  • Author(s): 原田結花，北村俊雄，原田浩徳
  • Journal Title: 血液内科 Volume: 68(6) Pages: 805-813
  • NAID: 40020139595
• [Journal Article] 広島原爆入市被曝者の移動経路の分析 (2014)
  • Author(s): 佐藤裕哉，佐藤健一，原 憲行，布施博之，原田結花
  • Journal Title: 長崎医学会雑誌 Volume: 89 Pages: 240-243
• [Journal Article] 骨髄系造血器腫瘍発症の分子機構 (2014)
  • Author(s): 北村俊雄，井上大地，中原史雄，大河内直子，加藤菜穂子，戸上勝仁，内田智之，鍵山侑希，川畑公人，永瀬玲奈，堀川小百合，林 康貴，齋賀真言，伊沢久未，沖 俊彦，千葉 滋，原田結花，原田浩徳，北浦次郎
  • Journal Title: 臨床血液 Volume: 55(10) Pages: 1715-1723
  • NAID: 130004696062
  • Peer Reviewed
• [Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in tnedevelopment of human and murine myelodysplastic syndromes. (2013)
  • Author(s): 原田結花、井上大地, 他
  • Journal Title: Blood Volume: 128(3) Issue: 17 Pages: 3434-3446
  • DOI: 10.1182/blood-2012-06-434423
  • Peer Reviewed
• [Journal Article] High early death rate in elderly patients with acute promyelocytic leukemia treated with all-trans retinoic acid combined chemotherapy (2013)
  • Author(s): Imagawa J, Harada Y, Shimomura T, Tanaka H, Okikawa Y, Harada H
  • Journal Title: Int J Hematol Volume: vol. 98(2) Issue: 2 Pages: 264-266
  • DOI: 10.1007/s12185-013-1390-0
  • NAID: 10031194747
  • Peer Reviewed
• [Journal Article] Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. (2013)
  • Author(s): Inoue, D
  • Journal Title: J. Clin. Invest. Volume: 123 Issue: 11 Pages: 4627-4640
  • DOI: 10.1172/jci70739
  • Peer Reviewed
• [Journal Article] MDSに対するメチル化阻害剤による治療の現状と展望 (2013)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液内科 Volume: 66(3) Pages: 316-322
• [Journal Article] 原田結花，原田浩徳 低リスクMDSに対するレナリドミド (2013)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液内科 Volume: 67(3) Pages: 305-312
• [Journal Article] CMML発症のゲノム異常 (2013)
  • Author(s): 原田結花，原田浩徳
  • Journal Title: 血液内科 Volume: 67(5) Pages: 631-637
  • NAID: 40019901709
• [Presentation] Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes (2016)
  • Author(s): 原田浩徳
  • Organizer: 第20回造血器腫瘍研究会
  • Place of Presentation: かずさアーク（千葉県木更津市）
  • Year and Date: 2016-02-12
• [Presentation] HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development (2015)
  • Author(s): Hayashi Y, Zhang Y, Yan X, Choi K, Sashida G, Dong Y , Xu Z, Wu L, Chen A, Sun X, Olsson A, Harada H, Shih L-Y, Tse W, Bridges J, Witte DP, Wang Q , Caligiuri MA, Grimes HL, Nimer SD, Xiao Z, Huang G
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, CA (USA)
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] Dysregulation of RUNX1 Plays a Critical Role in the Progression of Myelodysplastic Syndromes (2015)
  • Author(s): Sakurai H, Harada Y, Matsui H, Nakajima H, Kitamura T, Komatsu N, Harada H
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, CA (USA)
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] A Patient-Derived EZH2 Mutant Induces MDS-like Diseases with Derepressed ABCG2 Expression in Mice (2015)
  • Author(s): Kawabata KC, Inoue D, Kitaura J, Harada Y, Goyama S, Harada H, Aburatani H, Kitamura T
  • Organizer: 57th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, CA (USA)
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] Overexpression of RUNX1 short isoform plays a pivotal role in the development of myelodysplastic syndromes (2015)
  • Author(s): Harada H, Sakurai H, Harada Y, Kitamura T, Komatsu N
  • Organizer: The RUNX Transcription Factors in Development and Disease
  • Place of Presentation: Rehovot (Israel)
  • Year and Date: 2015-10-18
  • Int'l Joint Research / Invited
• [Presentation] Nationwide epidemiological survey of familial platelet disorder in Japan (2015)
  • Author(s): Toya T, Yoshimi A, Takaoka K, Nannya Y, Kirito K, Ito E, Nakajima H, Hayashi Y, Takahashi T, Moriya-Saito A, SuzukiK, Harada H, Komatsu N, Usuki K, Ichikawa M, Kurokawa M
  • Organizer: The 77th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: ホテル日航金沢 他（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Overexpression of RUNX1 short isoform plays a pivotal role in the development of MDS/MPN (2015)
  • Author(s): Sakurai H, Harada Y, Matsui H, Nakajima H, Doki N, Kakihana K, Ohashi K, Kitamura T, Komatsu N, Harada H
  • Organizer: The 77th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: ホテル日航金沢 他（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Truncated form EZH2 promotes stemness of MDS via derepression of stemness related genes (2015)
  • Author(s): Kawabata KC, Inoue D, Hayashi Y, Harada H, Goyama S, Kitaura J, Kitamura T
  • Organizer: The 77th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: ホテル日航金沢 他（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Analysis of MDS mice model induced by ASXL1 and RUNX1 mutations. (2015)
  • Author(s): Nagase R, Inoue D, Saika M, Hou H-A, Chou W-C, Kawabata KC, Harada H, Goyama S, Hwai-Fang T, Kitamura T
  • Organizer: The 77th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: ホテル日航金沢 他（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Investigation of a causal gene of familial myelodysplastic syndromes (2015)
  • Author(s): Takaoka K, Kawazu M, Yoshimi A, Toya T, Kobayashi T, Nannya Y, Ueno H, Suzuk K, Harada H, Manabe A, Hayashi Y, Mano H, Kurokawa M
  • Organizer: The 77th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: ホテル日航金沢 他（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Overexpression of RUNX1 short isoform plays a pivotal role in the development of MDS/MPN (2015)
  • Author(s): Sakurai H, Harada Y, Matsui H, Nakajima H, Doki N, Kakihana K, Ohashi K, Kitamura T, Komatsu N, Harada H
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: （愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Inactivation of EZH2 by truncated form mutation depresses stemness-related genes and promote myelodysplastic syndrome (2015)
  • Author(s): Kawabata KC, Inoue D, Hayashi Y, Harada H, Goyama S, Kitaura J, Kitamura T
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Nationwide epidemiological survey of familial platelet disorder in Japan (2015)
  • Author(s): Toya T, Yoshimi A, Nannya Y, Takaoka K, Kirito K, Nakajima H, Hayashi Y, Takahashi T, Harada H, Komatsu N, Ichikawa M, Kurokawa M
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] A candidate causal gene of familial myelodysplastic syndromes (2015)
  • Author(s): Takaoka K, Kawazu M, Yoshimi A, Toya T, Kobayashi T, Nannya Y, Ueno H, Harada H, Hayashi Y, Mano H, Kurokawa M
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Overexpression of RUNX1 short isoform plays a pivotal role in the development of myelodysplastic syndromes/ myeloproliferative neoplasms (2015)
  • Author(s): Sakurai H, Harada Y, Matsui H, Nakajima H, Kitamura T, Komatsu N, Harada H
  • Organizer: ISEH 44th Annual Scientific Meeting
  • Place of Presentation: Kyoto International Conference Center (Kyoto, Japan)
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] 機能獲得型RUNX1変異による骨髄異形成症候群の発症機序 (2015)
  • Author(s): 原田浩徳
  • Organizer: 第19回造血器腫瘍研究会
  • Place of Presentation: グランテはがくれ（佐賀県佐賀市）
  • Year and Date: 2015-01-23 – 2015-01-24
• [Presentation] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS (2014)
  • Author(s): Inoue D, Matsui H, How HA, Chou WC, Nagamachi A, Kitaura J, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada H, Tien HF, Abdel-Wahab O, Kitamura T
  • Organizer: The 56th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] C-terminal truncation type of RUNX1 mutants induce MDS/AML via gain-of-function mechanisms (2014)
  • Author(s): Harada H, Harada Y, Inoue D, Ding Y, Sashida G, Iwama A, Nakajima H, Tanaka J, KomatsuN, Kitamura T
  • Organizer: The 76th Annual Meetingof the Japanese Society of Hematology
  • Place of Presentation: 大阪国際会議場（大阪市北区）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Impaired platelet function in FPD/AML patients (2014)
  • Author(s): Sakurai M, Watanabe N, Kunimoto H, Fukuchi Y, Sadahira K, Abe D, Soma S, Ito E, Harada Y, Harada H, Okamoto S, Nakajima H
  • Organizer: The 76th Annual Meetingof the Japanese Society of Hematology
  • Place of Presentation: 大阪国際会議場（大阪市北区）
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] 機能獲得型RUNX1変異による骨髄異形成症候群の発症機序 (2014)
  • Author(s): 原田浩徳
  • Organizer: 2014新学術領域細胞運命制御班会議
  • Place of Presentation: 東京大学医科学研究所講堂（東京都港区）
  • Year and Date: 2014-09-02 – 2014-09-04
• [Presentation] C-terminal truncation type of RUNX1 mutants induce MDS/AML via gain-of-function mechanisms (2014)
  • Author(s): Harada H, Harada Y, Inoue D, Sashida G, Iwama A, Nakajima H, KomatsuN, Kitamura T
  • Organizer: ISEH 43rd Annual Scientific Meeting
  • Place of Presentation: Montreal (Canada)
  • Year and Date: 2014-08-21 – 2014-08-24
• [Presentation] RUNX1/AML1 mutants collaborate with BMI1 in the development of myelodysplastic syndromes (2013)
  • Author(s): Harada H, Harada Y, Inoue D, Kitamura T
  • Organizer: EMBO Workshop RUNX transcription factors in development & disease (19th International RUNX Workshop)
  • Place of Presentation: Wilsede, Germany
  • Invited
• [Presentation] アザシチジンによるMDS治療．［ランチョンセミナー：骨髄異形成症候群（MDS）の分子病態、診断と治療］ (2013)
  • Author(s): 原田浩徳
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study) (2013)
  • Author(s): Kobayashi T, Nannya Y, Ichikawa M, Kohara T, Kobune M, Harada H, Yonemura Y, Matsuda A, Kawabata H, Tohyama K, Miyazaki Y, Kurokawa M
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] Preliminary results of a randamized dose-finding study of darbepoetin alfa in MDS in Japan and Korea (2013)
  • Author(s): Shibayama H, Harada H, Jun Ho Jang, Suzuki K, Tsudo M, Ishikawa T, Uike N, Hidaka M, Usuki K, Shimizu S, Kim Y-J, Kim H, Kizaki M, Chiba S, Nannya Y, Yonemura Y, Sawa M, Ogura H, Nakazato T, Kumagai T, Kiguchi T, Takahashi T, Irie S, Mitani K, Sawada K, et al.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] RUNX1 mutant collaborates with BMI1 overexpression in the development of human and murine MDS/AML (2013)
  • Author(s): Harada H, Harada Y, Inoue D, Ding Y, Matsui H, Sashida G, Iwama A, Kitamura T
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] RUNX3 overexpression may participaten in the development of MDS/AML (2013)
  • Author(s): Miyama T, Harada Y, Ichinose T, Harada H
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Sapporo, Japan
• [Presentation] C-terminal-truncating ASXL1 mutations induce MDS via inhibition of PRC2 (2013)
  • Author(s): Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Oki T, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T
  • Organizer: The 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Presentation] The genetic landscape of FPD/AML revealed CDC25C mutation as a driver that promotes malignant transformation (2013)
  • Author(s): Yoshimi A, Toya T, Nakagawa M, Kawazu M, Nannya Y, Ichikawa M, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Mano H, Kurokawa M
  • Organizer: The 55th ASH Annual Meeting and Exposition
  • Place of Presentation: New Orleans, USA
• [Book] 骨髄異形成症候群（MDS）の基礎と臨床 改訂版，朝長万左男編，(分担執筆，MDSの遺伝子異常スペクトラムと臨床的意義) (2015)
  • Author(s): 原田結花，原田浩徳
  • Total Pages: 323
  • Publisher: 医薬ジャーナル社
• [Book] Principles and Practice 血液・造血器・リンパ系，千葉 滋編（分担執筆，遺伝子検査） (2015)
  • Author(s): 原田結花，原田浩徳
  • Total Pages: 385
  • Publisher: 文光堂
• [Book] 骨髄異形成症候群．ガイドライン外来診療2015 (2015)
  • Author(s): 原田浩徳
  • Total Pages: 694
  • Publisher: 日経メディカル開発
• [Book] エピゲノム異常と発がん 新・カラーテキスト血液病学（木崎昌弘編） (2013)
  • Author(s): 原田結花，原田浩徳
  • Total Pages: 687
  • Publisher: 中外医学社