| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
CAV1 was proved to overexpress like CADM1 (also known as TSLC1) in comprehensive gene expression analysis from a series of studies on adult T cell leukemia (ATL). CAV1 was found to exist not only in the cell but also in the secreted particle “Exosome” from the results of immunological analysis (e.g. ELISA or WB). Recently, it was pointed out that CAV1 is secreted into the patient blood of prostate cancer frequently occurring in elderly men. Surprisingly it was revealed that CAV1 exists in Exosome particle like our knowledge obtained in the research of ATL. On the other hand, CADM1 was suggested that is possible to overexpress for the reason that not only NF-kB was a specific transcription activator of CADM1 but also p47 that leads NF-kB to protein degradation by lysosome was constitutively down-regulated in ATL cells.
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