Novel strategy against GVHD using NB-UVB with expansion of Treg cells
| Project/Area Number |
25461429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Sato Tsutomu 札幌医科大学, 医学部, 講師 (40404602)
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| Co-Investigator(Kenkyū-buntansha) |
Iyama Satoshi 札幌医科大学, 医学部, 助教 (50398319)
河野 豊 札幌医科大学, 医学部, 助教 (80398320)
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| Co-Investigator(Renkei-kenkyūsha) |
Kawano Yutaka 札幌医科大学, 医学部, 助教 (80398320)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GVHD / NB-UVB / Treg |
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| Outline of Final Research Achievements |
Narrowband ultraviolet B (NB-UVB) has been widely used in dermatological phototherapy. As for the application of NB-UVB phototherapy to GVHD, we previously reported that it was highly efficacious for cutaneous lesions of acute GVHD (aGVHD) and that expansion of regulatory T (Treg) cells induced by NB-UVB might be one of the mechanisms. In order to examine whether NB-UVB irradiation through expansion of Treg cells is effective for the treatment of not only cutaneous aGVHD but also aGVHD of inner organs such as the intestine or liver, we conducted experiments in which a murine lethal aGVHD model, characterized by severe involvement of the intestine, were irradiated with NB-UVB. We found that NB-UVB irradiation improved the clinical score and survival rate. The numbers of infiltrating Treg cells in inflamed tissue of the intestine and those in spleen were increased in mice treated with NB-UVB.
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Report
(4 results)
Research Products
(4 results)
