The development of methods clarifying MDS patients with high risk-transformation into AML

• Project/Area Number: 25461431
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Fukushima Medical University
• Principal Investigator: Hideyoshi Noji 福島県立医科大学, 医学部, 講師 (20347214)
• Co-Investigator(Kenkyū-buntansha): SHICHISHIMA Tsutomu 福島県立医科大学, 医学部, 研究員 (10192105) ; 小川 一英 福島県立医科大学, 医学部, 教授 (40423800)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Kazuei 福島県立医科大学, 医学部, 教授 (40423800)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MDS / transformation / 後天性骨髄不全症候群 / マイクロアレイ / 骨髄異形成症候群 / 急性骨髄性白血病

Outline of Final Research Achievements

We will develop methods clarifying MDS patients with high risk-transformation into AML using gene set found by our new micro array methods. We used bone marrow clots of patients with refractory anemia with excess of blast (RAEB）at diagnosis and transforming into AML. In additions, we used bone marrow samples of healthy volunteers, and patients with megaroblastic anemia, paroxysmal nocturnal hemoglobinuria, aplastic anemia, and hypoplastic MDS.

Research Products

• [Journal Article] Molecular response of e19a2 BCR-ABL1 chronic myeloid leukemia with double Philadelphia chromosome by dasatinib (2016)
  • Author(s): Ikeda K, Harada-Shirado K, Matsumoto H, Noji H, Ogawa K, Takeishi Y
  • Journal Title: Journal of Clinical Oncology Volume: 34 Issue: 14 Pages: e130-e133
  • DOI: 10.1200/jco.2013.51.1188
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of clinical characteristics and prognostic factors for angioimmunoblastic T-cell lymphoma. (2015)
  • Author(s): Kameoka Y, Takahashi N, Itou S, Kume M, Noji H, Kato Y, Ichikawa Y, Sasaki O, Motegi M, Ishiguro A, Tagawa H, Ishizawa K, Ishida Y, Ichinohasama R, Harigae H, Sawada K.
  • Journal Title: Int J Hematol Volume: 101 Issue: 6 Pages: 536-542
  • DOI: 10.1007/s12185-015-1763-7
  • Peer Reviewed / Open Access
• [Journal Article] Increase in dicentric chromosome formation after a single CT scan in adults. (2015)
  • Author(s): Abe Y, Miura T, Yoshida MA, Ujiie R, Kurosu Y, Kato N, Katafuchi A, Tsuyama N, Ohba T, Inamasu T, Shishido F, Noji H, Ogawa K, Yokouchi H, Kanazawa K, Ishida T, Muto S, Ohsugi J, Suzuki H, Ishikawa T, Kamiya K, Sakai A.
  • Journal Title: Scinetific Reports Volume: 9 Issue: 1 Pages: 13882-13882
  • DOI: 10.1038/srep13882
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Post-engraftment blood transfusion and outcomes of bone marrow transplantation (2015)
  • Author(s): Mashimo Y, Ikeda K, Ohkawara H, Takahashi H, Shichishima-Nakamura A, Furukawa M, Kimura S, Ueda K, Noji H, Ogawa K, Nollet K, Ohto H, Takeishi Y
  • Journal Title: ISBT Science Series Volume: 10 Issue: 2 Pages: 93-99
  • DOI: 10.1111/voxs.12230
  • Peer Reviewed
• [Journal Article] A prospective analysis of clinical efficacy and safety in chronic myeloid leukemia-chronic phase patients with imatinib resistance or intolerance as evaluated using European LeukemiaNet 2013 criteria (2015)
  • Author(s): 2.Murai K, Akagi T, Shimosegawa K, Sugawara T, Ishizawa K, Ito S, Murai K, Motegi M, Yokoyama H, Noji H, Tajima K, Kimura J, Chou T, Ogawa K, Harigae H, Kubo K, Oba K, Sakamoto J, Ishida Y
  • Journal Title: Eur J Haematol Volume: Feb 19 Issue: 6 Pages: 12536-12536
  • DOI: 10.1111/ejh.12536
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms. (2015)
  • Author(s): Harada-Shirado K, Ikeda K, Ogawa K, Ohkawara H, Kimura H, Kai T, Noji H, Morishita S, Komatsu N, Takeishi Y.
  • Journal Title: Brit J Haematol. Volume: 168 Issue: 3 Pages: 338-349
  • DOI: 10.1111/bjh.13129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic variants in C5 and poor response to eculizumab. (2014)
  • Author(s): Nishimura J, Inazawa J, et al.
  • Journal Title: N Engl J Med. Volume: 370 Issue: 7 Pages: 632-9
  • DOI: 10.1056/nejmoa1311084
  • Peer Reviewed / Open Access
• [Journal Article] A new method for maturity-dependent fractionation of neutrophil progenitors applicable for the study of myelodysplastic syndromes. (2014)
  • Author(s): Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J.
  • Journal Title: Biomark Res. Volume: 2 Issue: 1 Pages: 1-3
  • DOI: 10.1186/2050-7771-2-2
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter phase II clinical trial of nilotinib for patients with imatinib-resistant or -intolerant chronic myeloid leukemia from the East Japan CML study group evaluation of molecular response and the efficacy and safety of nilotinib. (2014)
  • Author(s): Takahashi N, Miura M, Kuroki J, Mitani K, Kitabayashi A, Sasaki O, Kimura H, Imai K, Tsukamoto N, Noji H, Kondo T, Motegi M, Kato Y, Mita M, Saito H, Yoshida C, Torimoto Y, Kimura T, Wano Y, Nomura J, Yamamoto S, Mayama K, Honma R, Sugawara T, Sato S, Shinagawa A, Abumiya M, Niioka T, Harigae H, Sawada K.
  • Journal Title: Biomark Res. Volume: 20;2(1) Issue: 1 Pages: 2-6
  • DOI: 10.1186/2050-7771-2-6
  • Peer Reviewed / Open Access
• [Journal Article] Somatic 15q break after long-term stable disease in acute myeloid leukemia (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Matsumoto H, Shiga Y, Furukawa M, Takahashi H, Ohkawara H, Noji H, Hashimoto Y, Waguri S, Watanabe S, Ogawa K, Takeishi Y
  • Journal Title: Clinical Lymphoma, Myeloma & Leukemia Volume: 14 Issue: 2 Pages: e69-e72
  • DOI: 10.1016/j.clml.2013.10.009
  • Peer Reviewed / Open Access
• [Journal Article] Pleural Solitary Fibrous Tumor Complicated with Autoimmune Hemolytic Anemia (2014)
  • Author(s): Takahashi H, Ohkawara H, Ikeda K, Harada-Shirado K, Furukawa M, Sukegawa M, Shichishima-Nakamura A, Noji H, Wakamatsu S, Tasaki K, Suzuki H, Ogawa K, Takeishi Y
  • Journal Title: Internal Medicine Volume: 53 Issue: 14 Pages: 1549-1552
  • DOI: 10.2169/internalmedicine.53.2121
  • NAID: 130004466404
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Severe Immune Thrombocytopenia Possibly Elicited by the Anti-influenza Viral Agent Peramivir (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Furukawa M, Sukegawa M, Takahashi H, Shichishima-Nakamura A, Ohkawara H, Noji H, Kawabata K, Saito S, Ohto H, Ogawa K, Takeishi Y
  • Journal Title: Internal Medicine Volume: 53 Issue: 20 Pages: 2369-2371
  • DOI: 10.2169/internalmedicine.53.2330
  • NAID: 130004699276
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Impairment of FOS mRNA Stabilization Following Translation Arrest in Granulocytes from Myelodysplastic Syndrome Patients. (2013)
  • Author(s): Feng X, Shikama Y, Shichishima T, Noji H, Ikeda K, Ogawa K, Kimura H, Takeishi Y, Kimura J
  • Journal Title: PLOS ONE Volume: 8 Issue: 4 Pages: e61107-e61107
  • DOI: 10.1371/journal.pone.0061107
  • Peer Reviewed
• [Journal Article] Pulmonary Hypertension and Refractory Heart Failure in a Patient with Crow-Fukase (POEMS) Syndrome (2013)
  • Author(s): Yokokawa T, Nakazato K, Kanno Y, Mizukami H, Kobayashi A, Yoshihisa A, Takahashi H, Shichishima-Nakamura A, Ohkawara H, Noji H, Suzuki H, Saitoh S, Ogawa K, Hisa S, Takeishi Y
  • Journal Title: Internal Medicine Volume: 52 Issue: 10 Pages: 1061-1065
  • DOI: 10.2169/internalmedicine.52.9256
  • NAID: 130003365601
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Presentation] Excessive TNF-α production results from reduction of c-Fos via aberrant expression of Mir-34a in neutrophils from myelodysplastic syndrome patients (2015)
  • Author(s): Shikama Y, Cao M, Ono T, Anzai M, Noji H, Feng X, Kimura H, Ogawa K, Ikeda K, Takeishi Y, Kimura J
  • Organizer: 57th American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: Orlando
  • Year and Date: 2015-12-05
• [Presentation] 本邦におけるPNH症例の病態 －東北PNH研究会 臨床研究より得られた新知見－ (2015)
  • Author(s): 野地秀義
  • Organizer: 第1回 埼玉東南部PNH研究会
  • Place of Presentation: さいたま
  • Year and Date: 2015-10-27
  • Invited
• [Presentation] Improvement of coagulation markers, but not hemolytic markers, in a PNH case treated with eculizumab (2015)
  • Author(s): Noji H, Takahashi H, Nishimura J, Shichishima-Nakamura A, Takeishi Y, Kinoshita T, Kanakura Y, Shichishima T
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] Morphological and cytogenetic analyses of bone marrow hematopoietic cells in patients with PNH (2015)
  • Author(s): Noji H, Murai K, Kameoka J, Itoh S, Ohnishi Y, Takahashi S, Saitoh S, Kimura H, Ikeda K, Takada K, et al
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] Excessive TNFalpha production via reduced expression of c-Fos in myelodysplastic syndromes (2015)
  • Author(s): Shikama Y, Cao M, Yamakawa K, Feng X, Anzai M, Ono T, Noji H, Kimura H, Ogawa K, Suzuki Y, Takeishi Y, Kimura J
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] Low-dose lenalidomide after MP induction in elderly patients with multiple myeloma: a phase II trial (2015)
  • Author(s): Onishi Y, Yokoyama H, Katsuoka Y, Ito T, Kimura T, Yamamoto J, Nakajima S, Sasaki O, Ara T, Ine S, Minauchi K, Fukuhara O, Noji H, Ota S, Kobayashi N, Harigae H
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] Safety and efficacy of recombinant thrombomodulin for DIC with leukemia: multicenter, phase II study (2015)
  • Author(s): Yokoyama H, Takahashi N, Kameoka Y, Noji H, Murai K, Omoto E, Katsuoka Y, Itou T, Meguro K, Ishizawa K, Ogawa K, Ishida Y, Sawada K, Harigae H
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] The PNH-type cells assessed by a standard flow cytometry using mAbs to GPI proteins or FLAER (2015)
  • Author(s): Takahashi H, Noji H, Shichishima-Nakamura A, Takeishi Y, Shichishima T
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] Transfusions after engraftment associate with non-relapse mortality in the setting of allo-HSCT (2015)
  • Author(s): Ueda K, Ikeda K, Mashimo Y, Ohkawara H, Takahashi H, Shichishima-Nakamura A, Harada-Shirado K, Furukawa M, Kimura S, Noji H, Ogawa K, Ohto H, Takeishi Y
  • Organizer: 第77回 日本血液学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-10-16
• [Presentation] OPTIMA試験：高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の測定の臨床的意義 -2015年中間報告（続報）- (2015)
  • Author(s): 林 悟, 植田康敬, 西村純一, 細川晃平, 杉盛千春, 米村雄士, 小原 直, 中村嘉彦, 野地秀義, 七島 勉, 安藤 潔, 二宮治彦, 千葉 滋, 川口辰哉, 金倉 譲, 中尾眞二
  • Organizer: 第52回 補体シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2015-08-21
• [Presentation] The interim study of prospective observational study with PNH-type cells in Japanese patients with bone marrow failure (The OPTIMA Study: Observation of PNH-type cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH) (2015)
  • Author(s): Obara N, Chiba S, Hosokawa K, Sugimori C, Yamamoto M, Noji H, Yonemura Y, Nakamura Y, Ando K, Kawaguchi T, Shichishima T, Ninomiya H, Nishimura J, Kanakura Y, Nakao S
  • Organizer: 20th Congress of European Hematology Association
  • Place of Presentation: Vienna
  • Year and Date: 2015-06-11
  • Int'l Joint Research
• [Presentation] The interim analysis of the OPTIMA (Observation of GPI-anchored protein-deficient [PNH-type] cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH) (2015)
  • Author(s): Sugimori C, Noji H, Shichishima T, Obara N, Chiba S, Ninomiya H, Nakamura Y, Ando K, Hosokawa K, Yamamoto M, Yonemura Y, Kawaguchi T, Nishimura J, Kanakura Y, Nakao S
  • Organizer: 6th JSH International Symposium 2015
  • Place of Presentation: Karuizawa
  • Year and Date: 2015-05-22
  • Int'l Joint Research
• [Presentation] The interim analysis of the optima observation of GPI-anchored protein-deficient (PNH-type) cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH study (2014)
  • Author(s): Noji H, Shichishima T, Sugimori C, Obara N, Hosokawa K, Chiba S, Nakamura Y, Ando K, Ando K, Hayashi S, Yonemura Y, Kawaguchi T, Ninomiya H, Nishimura J, Kanakura Y, Nakao S
  • Organizer: 2014 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Impact of red blood cell and platelet transfusions at early after engraftment on outcome of allogeneic hematopoietic stem cell transplantation (2014)
  • Author(s): Ikeda K, Mashimo Y, Ohkawara H, Takahashi H, Shichishima-Nakamura A, Harada-Shirado K, Furukawa M, Noji H, Ogawa K, Ohto H, Takeishi Y
  • Organizer: 2014 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-06 – 2014-12-09
• [Presentation] Relationship between thrombosis and coagulation markers in patients with PNH (2014)
  • Author(s): Noji H, Ohnishi Y, Kimura S, Takahashi S, Kimura H, et al
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Improvement of coagulation markers, but not hemolytic markers, in a PNH case treated with eculizumab (2014)
  • Author(s): Noji H, Takahashi H, Nishimura J, Shichishima A, Yamamoto M, Shibayama H, Hase M, Li L, Johnson K, Tamburini P, Takeishi Y, Kinoshita T, Kanakura Y, Shichishima T
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Analysis of the MCNU-based high dose chemotherapy followed by ASCT for relapsed or refractory DLBCL (2014)
  • Author(s): Kameoka Y, Takahashi N, Akagi T, Nara M, Ine S, Kato Y, Yokoyama H, Noji H, Itou S, Ishida Y, Harigae H, Sawada K
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Correlation of HMGA2 mRNA and let-7 micro RNAs with Methylation of p16 in MPNs (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Ogawa K, Noji H, Ohkawara H, Kimura H, kai T, Morishita S, Komatsu N, Takeishi Y
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Effects of miR-34a/miR-155-mediated c-Fos reduction on TNFα production in myelodysplastic syndromes (2014)
  • Author(s): Shikama Y, Cao M, Yamakawa K, Feng X, Anzai M, Ono T, Noji H, Ogawa K, Suzuki Y, Kimura H, Takeishi Y, Kimura J
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Takahashi H, Noji H, Takeishi Y, Shichishima T (2014)
  • Author(s): A study on telomere lengths of granulocytes and lymphocytes from PNH patients
  • Organizer: 第76回 日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] Interim report of the optima observation of GPI-anchored protein deficient (PNH-type) cells in Japanese patients with bone marrow failure syndrome and in those suspected of having PNH study (2014)
  • Author(s): Chiharu Sugimori, Kohei Hosokawa, Hideyoshi Noji, Tsutomu Shichishima, Naoshi Obara, Shigeru Chiba, Yoshihiko Nakamura, Kiyoshi Ando, Masaki Yamamoto, Yuji Yonemura, Tatsuya Kawaguchi, Haruhiko Ninomiya, Jun-ichi Nishimura, Yuzuru Kanakura, Shinji Nakao
  • Organizer: The 19th Congress of European Hematology Association
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] The role of deregulated HMGA2 expression due to repressed let-7 micro RNA in myeloproliferative neoplasm (MPNs) (2014)
  • Author(s): Harada-Shirado K, Ikeda K, Ogawa K, Noji H, Ohkawara H, Kimura H, Kai T, Morishita S, Komatsu N, Takeishi Y
  • Organizer: The 5th JSH International Symposium 2014
  • Place of Presentation: Hamamatsu, Japan
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] Double Ph染色体にmicro BCR-ABLを伴ったCMLの一例
  • Author(s): 原田佳代, 池田和彦, 古川未希, 高橋裕志, 松本勇人, 大河原浩, 野地秀義, 田崎和洋, 小川一英, 竹石恭知
  • Organizer: 第19回 造血器腫瘍研究会
  • Place of Presentation: 福島市
• [Presentation] OPTIMA Study, T-PIGおよび自検例の紹介
  • Author(s): 野地秀義
  • Organizer: 北海道PNH研究会
  • Place of Presentation: 札幌市
• [Presentation] Breast tumor as a presentation of extranodal T-cell lymphoblastic lymphoma-clinical and pathological analysis
  • Author(s): Harada-Shirado K, Ikeda K, Hashimoto Y, Kawana S, Matsumoto H, Ohkawara H, Noji H, Abe M, Ogawa K, Takeishi Y
  • Organizer: The 4th JSH International Symposium 2013 in Ehime
  • Place of Presentation: Matsuyama, Japan
• [Presentation] PNHの病態と治療戦略
  • Author(s): 野地秀義
  • Organizer: 大阪PNHフォーラム2013
  • Place of Presentation: 大阪市
  • Invited
• [Presentation] OPTIMA試験：高精度フローサイトメトリー法によるGPI アンカー膜蛋白欠損血球の検出
  • Author(s): 山本正樹, 西村純一, 細川晃平, 杉盛千春, 米村雄士, 小原 直, 中村嘉彦, 野地秀義, 七島 勉, 安藤 潔, 二宮治彦, 千葉 滋, 川口辰哉, 中尾眞二, 金倉 譲
  • Organizer: 第50回 補体シンポジウム
  • Place of Presentation: 旭川市
• [Presentation] 福島県における血液疾患治療の治療連携
  • Author(s): 野地秀義
  • Organizer: 第60回 福島血液研究会
  • Place of Presentation: 福島市
  • Invited
• [Presentation] ラスブリカーゼにより透析離脱後、寛解に導入し得たバーキットリンパ腫/白血病の一例
  • Author(s): 阿部 理, 池田和彦, 原田佳代, 古川未希, 松本勇人, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 竹石恭知
  • Organizer: 第60回 福島血液研究会
  • Place of Presentation: 福島市
• [Presentation] 両眼瞼マルトリンパ種治療後に発症したDLBCLの一例
  • Author(s): 前田亜希子, 三澤恭平, 角田三郎, 太田雅嗣, 北條 洋, 野地秀義, 池田和彦
  • Organizer: 第60回 福島血液研究会
  • Place of Presentation: 福島市
• [Presentation] ダサチニブにより良好な治療反応が得られたµ-BCR/ABL陽性慢性骨髄性白血病 (CML)
  • Author(s): 池田和彦, 原田佳代, 古川未希, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 竹石恭知
  • Organizer: 第116回 日本血液学会東北地方会
  • Place of Presentation: 青森市
• [Presentation] Safety and efficacy of MEAM followed by auto-HSCT for malignant lymphoma:THF multicenter study
  • Author(s): Kameoka Y, Takahashi N, Akagi T, Nara M, Ine S, Kato Y, Yokoyama H, Noji H, Murai K, Ishida Y, Harigae H, Sawada K
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Expression of HMGA2 in granulocytes from patients with myeloproliferative neoplasms (MPNs)
  • Author(s): Harada-Shirado K, Ikeda K, Ogawa K, Noji H, Kimura H, Kai T, Morishita S, Komatsu N, Takeishi Y
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] The causes of macrocytic anemia in 933 patients: MCV 115 as a marker of authentic macrocytic anemia
  • Author(s): Kameoka J, Takahashi N, Takahashi N, Tamai Y, Murai K, Yokoyama H, Noji H, Honma R, Tohmiya Y, Kato Y, Harigae H, Ishida Y, Sawada K
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Inherent resistance to eculizumab in PNH
  • Author(s): Yamamoto M, Nishimura u, Hayashi S, Ohyashiki K, Ando K, Noji H, Kitamura K, Eto T, Ando T, Masuko M, Shichishima T, Shibayama H, Hase M, Inazawa J, Kinoshita T, Kanakura Y
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] A study on IgG and C3 bound to erythrocytes in paroxysmal nocturnal hemoglobinuria (PNH) patients
  • Author(s): Noji H, Kamesaki T, Shichishima-Nakamura A, et al
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] The OPTIMA update: Baseline assessment of PNH-type cells in patients with bone marrow failure
  • Author(s): Yonemura Y, Kawaguchi T, Hosokawa K, Sugimori C, Yamamoto M, Obara N, Noji H, Nakamura Y, Ando K, Shichishima T, Ninomiya H, Chiba S, Kanakura Y, Nakao S
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Expression of NECDIN in acute myeloid leukemia (AML)
  • Author(s): Ikeda K, Ogawa K, Harada-Shirado K, Shiga Y, Furukawa M, Takahashi H, Matsumoto H, Ohkawara H, Noji H, Takeishi Y
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Myelodysplastic syndromes with del(13) in a patient with paroxysmal nocturnal hemoglobinuria (PNH)
  • Author(s): Kimura S, Noji H, Takahashi H, Kimura S, Saitoh Y, Kanbayashi H, Matsuda S, Odajima H, Takeishi Y, Shichishima T
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Yokoyama H, Itoh T, Kawajiri A, Fujiwara M, Noji H, Shichishima T, Meguro K
  • Author(s): Efficacy of eculizumab for thrombosis resistant to anticoagulant therapy alone in a case of PNH
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] A study on telomere lengths of granulocytes and lymphocytes from PNH patients
  • Author(s): Takahashi H, Noji H, Shichishima-Nakamura A, Takeishi Y, Shichishima T
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Impaired stabilization of FOS mRNA in myelodysplastic syndrome-derived neutrophils
  • Author(s): Shikama Y, Feng X, Cao M, Kimura H, Noji H, Ogawa K, Ikeda K, Shichishima T, Takeishi Y, Kimura J
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] Noji H, Isonishi A, Fujimura Y, Takeishi Y, Shichishima T
  • Author(s): Noji H, Isonishi A, Fujimura Y, Takeishi Y, Shichishima T
  • Organizer: 第75回 日本血液学会学術集会
  • Place of Presentation: 札幌市
• [Presentation] CD8+CD56+EBV-節外性リンパ腫の2例
  • Author(s): 古川未希, 池田和彦, 原田佳代, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 竹石恭知, 橋本優子
  • Organizer: 第29回 悪性リンパ腫（M.L.）研究会
  • Place of Presentation: 郡山市
• [Presentation] 疾患別Q&A分科会 骨髄異形成症候群
  • Author(s): 野地秀義
  • Organizer: 血液がん ～より良い治療とより良い治癒～
  • Place of Presentation: 郡山市
  • Invited
• [Presentation] Baseline assessment of GPI-anchored protein deficient blood cells in patients with bone marrow failure (The OPTIMA study)
  • Author(s): Obara N, Chiba S, Hosokawa K, Sugimori C, Yamamoto M, Noji H, Yonemura Y, Nakamura Y, Ando K, Kawaguchi T, Shichishima T, Ninomiya H, Nishimura J, Kanakura Y, Nakao S
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] The role of deregulated HMGA2 expression with promoter methylation of p16 in myeloproliferative neoplasms
  • Author(s): Shirado-Harada K, Ikeda K, Ogawa K, Noji H, Kimura H, Kai T, Morishita S, Komatsu N, Takeishi Y
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab in 11 Japanese patients with PNH
  • Author(s): Nishimura J, Yamamoto M, Hayashi S, Ohyashiki K, Ando K, Noji H, Kitamura K, Eto T, Takahashi T, Masuko M, Matsumoto T, Wano Y, Shichishima T, Shibayama H, Hase M, Lan L, Johnson K, Tamburini P, Inazawa J, Kinoshita T, Kanakura Y
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] The prospective analysis of clinical efficacy and adverse events in chronic myeloid leukemia in chronic phase (CML-CP) patients with imatinib resistance or intolerance, evaluated by European Leukemia Net (ELN) 2013 Criteria
  • Author(s): Murai K, Akagi T, Shimosegawa K, Ishizawa K, Sugawara T, Yokoyama H, Noji H, Ogawa K, Tajima K, Oba K, Sakamoto J, Kubo K, Sakamaki H, Harigae H, Ishida Y
  • Organizer: 2013 American Society of Hematology (ASH) Annual Meeting and Exposition
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] 抗インフルエンザウイルス薬（ペラミビル）投与後に発症した重篤な血小板減少症の1例
  • Author(s): 原田佳代, 池田和彦, 古川未希, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 竹石恭知
  • Organizer: 第201回 日本内科学会東北地方会
  • Place of Presentation: 仙台市
• [Presentation] 低形成骨髄異形成症候群（h-MDS）の病態の検討
  • Author(s): 野地秀義
  • Organizer: 第8回 TOHOKU HEMATOLOGY FORUM
  • Place of Presentation: 仙台市
• [Presentation] EBV感染を伴わないCD8+CD56+節外性リンパ腫の2例
  • Author(s): 古川未希, 池田和彦, 原田佳代, 助川真純, 高橋裕志, 七島晶子, 大河原浩, 野地秀義, 小川一英, 橋本優子, 竹石恭知
  • Organizer: 第117回 日本血液学会東北地方会
  • Place of Presentation: 仙台市
• [Presentation] POEMS症候群に対してauto PBSCTを施行した一例
  • Author(s): 助川真純, 高橋裕志, 大河原浩, 七島晶子, 横川哲朗, 古川未希, 原田佳代, 松本勇人, 池田和彦, 野地秀義, 小川一英, 大戸 斉, 竹石恭知
  • Organizer: 第36回 日本造血細胞移植学会総会
  • Place of Presentation: 宜野湾市