Development of a specific antibody therapy for newly identified CD34 antigen-negative leukemic stem cell niche
| Project/Area Number |
25461438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SONODA Yoshiaki 関西医科大学, 医学部, 教授 (60206688)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 白血病幹細胞 / 抗体療法 |
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| Outline of Final Research Achievements |
We conducted a study for development of antibody therapy against leukemic stem cells (LSC) that cause a recurrence of leukemia. At first, we identified CD34-negative LSCs that are more undifferentiated than LSCs hitherto known. Then, antibodies against CD34-negative LSCs were produced. Analyzing of target epitopes of this produced antibodies, an antigen were identified as a promising target for a new leukemic treatment. This antibody exerted anti-leukemic cell effects in in vitro experiments.
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Report
(4 results)
Research Products
(1 results)
