Clinical application of activated NK cell therapy
Project/Area Number |
25461443
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Tokyo Women's Medical University |
Principal Investigator |
Tanaka Junji 東京女子医科大学, 医学部, 教授 (50250452)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | NK細胞 / 細胞療法 / 悪性リンパ腫 / 免疫療法 |
Outline of Final Research Achievements |
We could establish the GMP-grade clinical NK cell expansion system under the condition with OKT3, tacrolimus, dalteparin and cytokines such as IL-2 and IL-15 using peripheral blood mononuclear cells (PBMC) from patients with hematological malignancies such as malignant lymphoma. Expanded NK cell had strong cytolytic activity against K562 human leukemic cell line without pre-sensitization. Using this system, we could planed autologous expanded NK cell therapy clinical trial with rituximab (Phase I/II) against relapse/refractory B cell malignant lymphoma.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Impact of MRD and TKI on allogeneic hematopoietic cell transplantation for Ph+ALL: a study from the Adult ALL WG of the JSHCT.2016
Author(s)
Nishiwaki S, Imai K, Mizuta S, Kanamori H, Ohashi K, Fukuda T, Onishi Y, Takahashi S, Uchida N, Eto T, Nakamae H, Yujiri T, Mori S, Nagamura-Inoue T, Suzuki R, Atsuta Y, Tanaka J.
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Journal Title
Bone Marrow Transplantation
Volume: 51
Issue: 1
Pages: 43-50
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of differently licensed KIR2DL1-positive natural killercells in transplant recipients with acute leukemia: a Japanese national registry study.2016
Author(s)
Arima N, Nakamura F, Yabe T, Tanaka J, Fuji S, Ohashi K, Fukuda T, Miyamura K, Iwato K, Eto T, Mori T, Kobayashi N, Hoshino T, Kato C, Kanamori H, Nakamae H, Atsuta Y, Morishima Y, Kanda Y.
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Journal Title
BBMT
Volume: 22
Issue: 3
Pages: 423-431
DOI
Related Report
Peer Reviewed
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[Journal Article] Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study.2016
Author(s)
Muroi K, Miyamura K, Okada M, Yamashita T, Murata M, Ishikawa T, Uike N, Hidaka M, Kobayashi R, Imamura M, Tanaka J, Ohashi K, Taniguchi S, Ikeda T, Eto T, Mori M, Yamaoka M, Ozawa K.
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Journal Title
Int J Hematol
Volume: 103
Issue: 2
Pages: 243-250
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparable outcomes between autologous and allogeneic transplant for adult acute myeloid leukemia in first complete remission.2016
Author(s)
Mizutani M, Hara M, Fujita H, Aoki J, Kanamori H, Ohashi K, Usuki K, Fukuda T, Chou T, Tanaka J, Atsuta Y, Takami A.
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Journal Title
BMT (in press)
Volume: NA
Issue: 5
Pages: 645-53
DOI
Related Report
Peer Reviewed
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[Journal Article] Cytomegalovirus reactivation in low-grade B-cell lymphoma patients treated with bendamustine.2016
Author(s)
Isono N, Imai Y, Watanabe A, Moriya K, Tamura H, Inokuchi K, Asano C, Masuda M, Shimura H, Mitsuhashi K, Kazama H, Sugimori H, Motoji T, Tanaka J
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Journal Title
Leukemia and Lymphoma
Volume: NA
Related Report
Peer Reviewed
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[Journal Article] Etoposide-containing conditioning regimen reduces the occurrence of hemophagocytic lymphohistiocytosis after SCT.2014
Author(s)
Kobayashi R, Tanaka J, Hashino S, Ota S, Torimoto Y, Kakinoki Y, Yamamoto S, Kurosawa M, Hatakeyama N, Haseyama Y, Sakai H, Sato K, Fukuhara T.
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Journal Title
Bone Marrow Transplant.
Volume: 49
Issue: 2
Pages: 254-257
DOI
Related Report
Peer Reviewed
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[Journal Article] Pre-transplant administration of imatinib for allogeneic hematopoietic stem cell transplantation in patients with BCR-ABL-positive acute lymphoblastic leukemia.2014
Author(s)
Mizuta S, Matsuo K, Imai K, Nishiwaki S, kanamori H, Ohashi K, Fukuda T, Onishi Y, Miyamura K, Takahashi S, Onizuka M, Suzuki R, Atsuta Y, Morishima Y, Kato K, Sakamaki H, Tanaka J.
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Journal Title
Blood
Volume: 123
Issue: 15
Pages: 2325-2332
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factor analysis of non-Hodgkin lymphoma-associated haemophagocytic syndromes: a multicentre study.2014
Author(s)
Sano H, Kobayashi R, Tanaka J, Hashino S, Ota S, Torimoto Y, Kakinoki Y, Yamamoto S, Kurosawa M, Hatakeyama N, Haseyama Y, Sakai H, Sato K, Fukuhara T.
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Journal Title
Br J Haematol.
Volume: 165
Issue: 6
Pages: 786-792
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of outcomes following autologous transplantation in adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia during the first complete remission.2014
Author(s)
Kato H, Kawase T, Kako S, Mizuta S, Kurokawa M, Mori M, Ohashi K, Iwato K, Miyamura K, Hidaka M, Sakamaki H, Suzuki R, Morishima Y, Tanaka J.
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Journal Title
Haematologica
Volume: 99
Issue: 11
Pages: e228-e230
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatitis B virus (HBV) reverse seroconversion (RS) can be prevented even in non-responders to hepatitis B vaccine after allogeneic stem cell transplantation: long-term analysis of intervention in RS with vaccine for patients with previous HBV infection2014
Author(s)
Takahata M, Hashino S, Onozawa M, Shigematsu A, Sugita J, Fujimoto K, Endo T, Kondo T, Tanaka J, Imamura M, Teshima T
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Journal Title
Transpl Infect Dis
Volume: 16(5)
Issue: 5
Pages: 797-801
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of kir ligand incompatibility on clinical outcomes of umbilical cord blood transplantation without atg for acute leukemia in complete remission2013
Author(s)
Tanaka J, Morishima Y, Takahashi Y, Yabe T, Oba K, Takahashi S, Taniguchi S, Ogawa H, Onishi Y, Miyamura K, Kanamori H, Aotsuka N, Kato K, Kato S, Atsuta Y, Kanda Y
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Journal Title
Blood Cancer J
Volume: 3
Issue: 11
Pages: 1-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced-intensity versus myeloablative conditioning allogeneic hematopoietic stem cell transplantation for patients aged over 45 years with acute lymphoblastic leukemia (ALL) in remission: A study from the Adult ALL Working Group of the Japan Society for Hematopoietic Cell Transplantation (JSHCT).2013
Author(s)
Tanaka J, Kanamori H, Nishiwaki S, Ohashi K, Taniguchi S, Eto T, Nakamae H, Minagawa K, Miyamura K, Sakamaki H, Morishima Y, Kato K, Suzuki R, Nishimoto N, Oba K, Masauzi N
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Journal Title
Bone Marrow Transplant.
Volume: 48
Issue: 11
Pages: 1389-1394
DOI
Related Report
Peer Reviewed
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[Presentation] Allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia who had central nervous system involvement: A study from the adult ALL working group of the JSHCT.2015
Author(s)
Shigematsu A, Kako S, Mitsuhashi K, Ohashi K, Uchida N, Fukuda T, Ogawa H, Miyamura K, Sakura T, Nagamura-Inoue T , Morishima Y, Ichinohe T, Atsuta Y, Mizuta S, Tanaka J.
Organizer
20th Congressof Europian Hematology Association (EHA)
Place of Presentation
Vienna, Austria.
Year and Date
2015-06-11
Related Report
Int'l Joint Research
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[Presentation] 抗腫瘍免疫とNK細胞2014
Author(s)
田中淳司
Organizer
第76回 日本血液学会総会 ランチョンセミナー
Place of Presentation
大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
Invited
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[Presentation] KIR-ligand incompatibility in the graft-versus-host direction did not affect outcomes of single umbilical cord blood transplantation without ATG for acute leukemia in complete remission.2013
Author(s)
Tanaka J, Takahashi Y, Yabe T, Morishima Y, Oba K, Takahashi S, Taniguchi S, Ogawa H, Ohnishi Y, Miyamura K, Kato K, Kato S, Atsuta Y, Kanda Y.
Organizer
8th Congressof Europian Hematology Association (EHA)
Place of Presentation
Stockholm
Related Report