Control of inhibitory immunoreceptor in cell therapy after allogeneic hematopoietic stem cell transplantation
Project/Area Number |
25461446
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ITO Yoshinori 名古屋大学, 医学系研究科, 准教授 (20373491)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 免疫抑制受容体 / 抗原特異的T細胞 / 抗原提示細胞 / 細胞療法 / 樹状細胞 / 人工抗原提示細胞 / ウイルス抗原特異的T細胞 / 同種造血幹細胞移植 |
Outline of Final Research Achievements |
Adenovirus serotype 11 (AdV-11) occasionally causes hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. A novel T-cell epitope (TYFNLGNKF) of AdV-11 presented by HLA-A*24:02 was identified, and the epitope indeed functions as a target for TYFNLGNKF-specific T cells in vivo. It was demonstrated that antigen-specific T cells could be generated rapidly and efficiently by the use of anti-4-1BB antibody without antigen-presenting cells. And PD-L1 expressed on antigen-presenting cells along with CD80/86 showed to enhance the induction of antigen-specific T cells. These findings are applicable to cell therapy in the future.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Simple and Efficient Generation of Virus-specific T Cells for Adoptive Therapy Using Anti-4-1BB Antibody2015
Author(s)
Nobuhiko Imahashi, Tetsuya Nishida, Tatsunori Goto, Seitaro Terakura, Keisuke Watanabe, Ryo Hanajiri, Reona Sakemura, Misa Imai, Hitoshi Kiyoi, Tomoki Naoe, and Makoto Murata
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Journal Title
Journal of Immunotherapy
Volume: 38(2)
Issue: 2
Pages: 62-70
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of a novel HLA-A^*24:02-restricted adenovirus serotype 11-specific CD8+ T-cell epitope for adoptive immunotherapy2013
Author(s)
Imahashi N, Nishida T, Ito Y, Kawada J, Nakazawa Y, Toji S, Suzuki S, Terakura S, Kato T, Murata M, Naoe T.
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Journal Title
Molecular Immunolgy
Volume: 56
Issue: 4
Pages: 399-405
DOI
Related Report
Peer Reviewed
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[Presentation] PD-L1 on Antigen-Presenting Cells Facilitate the Induction of Antigen-Specific Cytotoxic T Lymphocytes2015
Author(s)
Goto T, Nishida T, Takagi E, Miyao K, Koyama D, Sakemura R, Hanajiri R, Watanabe K, Imahashi N, Terakura S, Murata M, Kiyoi H
Organizer
57th American Society of Hematology Annual Meeting and Exposition
Place of Presentation
米国、オーランド
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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