Establishing biomarkers for assessment of intestinal mucosal injury in hematopietic stem cell transplantation
Project/Area Number |
25461454
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | International University of Health and Welfare |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
久保田 寧 佐賀大学, 医学部, 病院講師 (60570413)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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Keywords | 血液内科学 / 造血幹細胞移植 / 化学療法 / 合併症 / バイオマーカー / 腸管粘膜損傷 / diamine oxidase / シトルリン / 栄養指標 / 消化管機能 |
Outline of Final Research Achievements |
Gastrointestinal tract mucositis is a common side effect when performing stem cell transplantation (SCT). Citrulline and diamine oxidase (DAO) levels are reported as specific markers of intestinal mucosal injury during cancer chemotherapy. We investigated whether the serial monitoring of these markers is useful to assess the severity of gastrointestinal tract complications during the early phase of reduced-intensity regimens, following cord blood stem cell transplantation (CBT). Serial monitoring of plasma citrulline, serum DAO levels and some laboratory parameters were performed in paients received HSCT.Both citrulline and DAO levels significantly decreased after the start of conditioning. Of note, the recovery of citrulline and DAO levels was delayed in the CBT group. The serial monitoring of citrulline and DAO levels might be promising biomarkers for assessing intestinal mucosal injury during CBT in clinical decision making.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Famotidine-induced reactive plasmacytosis and generalized lymphadenopathy: a case report and review of the literature2016
Author(s)
Hiroaki Kitamura, Yasushi Kubota, Noriyasu Fukushima, Tatsuo Ichinohe, Daisuke Hayasaka, Kazuharu Kamachi, Mari Yoshihara, Hidekazu Itamura, Takashi Hisatomi, Kazuo Wakayama, Eisaburo Sueoka, Shinya Kimura
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Journal Title
Int J Clin Exp Pathol
Volume: 9
Pages: 7680-7685
Related Report
Peer Reviewed / Open Access
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[Journal Article] High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.2016
Author(s)
Andersson E, Tanahashi T, Sekiguchi N, Gasparini VR, Bortoluzzi S, Kawakami T, Matsuda K, Mitsui T, Eldfors S, Bortoluzzi S, Coppe A, Binatti A, Lagstrom S,Ellonen P, Fukushima N, Nishina S, Senoo N, Sakai H, Nakazawa H, Kwong YL, Loughran TP, Maciejewski JP, Mustjoki S, Ishida F.
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Journal Title
Blood
Volume: 128
Issue: 20
Pages: 2465-2468
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Therapeutic management in cardiac lymphoma.2014
Author(s)
Yoshihara M, Itamura H, Fukushima N, Itoh M, Furukawa K, Nagatomo D, Kamachi K, Kitamura H, Shindo T, Kubota Y, Sueoka E, Morita S, Ichinohe T, Kimura S.
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Journal Title
Leukemia and Lymphoma
Volume: 55
Issue: 5
Pages: 1215-1217
DOI
Related Report
Peer Reviewed
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[Journal Article] Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A).2014
Author(s)
Fukushima T, Nomura S, Shimoyama M, Shibata T, Imaizumi Y, Moriuchi Y, Tomoyose T, Uozumi K, Kobayashi Y, Fukushima N, Utsunomiya A, Tara M, Nosaka K, Hidaka M, Uike N, Yoshida S, Tamura K, Ishitsuka K, Kurosawa M, Nakata M, Fukuda H, Hotta T, Tobinai K, Tsukasaki K.
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Journal Title
Br J Haematol
Volume: 166
Issue: 5
Pages: 739-748
DOI
Related Report
Peer Reviewed
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[Journal Article] A Novel Frameshift Mutation in Exon 4 Causing a Deficiency of High-molecular-weight Kininogen in a Patient with Splenic Infarction2014
Author(s)
Fukushima N, Itamura H, Wada H, Ikejiri M, Igarashi Y, Masaki H, Sano M, Komiyama Y, Ichinohe T, Kimura S.
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Journal Title
Internal Medicine
Volume: 53
Issue: 3
Pages: 253-257
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Presentation] Prognostic biomarkers in patients with locakized NK/T-cell lymphoma treated with RT-DeVIC2014
Author(s)
Takata, K, Yamaguchi M,Yoshino T,Ishizuka T, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubuto N, Itoh K, Usui N, Miyazaki K, Utsumi T, Masaki Y, Nosaka K, Fukushima N, Ohmachi K, Shimada K Morimoto H, Tsukamoto N, Inoue Y, Yakushijin Y, Wasada I, Nakamura S, Matsuo Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] A case of anaplastic large cell lymphoma, ALK- with T-LGL leukemia expressing aberrant phenotype2013
Author(s)
Kazuharu Kamachi, Noriyasu Fukushima, Hiroaki Kitamura, Mari Yoshihara, Hidekazu Itamura, Mariko Yoshimura, Masako Yokoo, Masaru Ide, Takero Shindo, Yasushi Kubota, Toshihiko Ando, Tatsuo Ichinohe, Eisabuzo Sueoka, Koichi Ohshima, Shinya Kimura
Organizer
第75回日本血液学会学術集会
Place of Presentation
ロイトン札幌他
Related Report
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[Presentation] Deferasirox in iron-overloaded patients with hematologic diseases at Saga University Hospital2013
Author(s)
Abe O, Yoshihara M, Kubota Y, Sueoka E, Kamachi K, Kitamura H, Itamura H, Nishi M, Shindo T, Fukushima N, Hamasaki Y, Kimura S
Organizer
第75回日本血液学会学術集会
Place of Presentation
ロイトン札幌他
Related Report
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