| Project/Area Number |
25461455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SUZUKI YUHKO 福島県立医科大学, 医学部, 講師 (80406941)
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| Co-Investigator(Kenkyū-buntansha) |
井上 浄 慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 (00433714)
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| Co-Investigator(Renkei-kenkyūsha) |
MINATO Nagahiro 京都大学, 医学研究科, 教授 (40137716)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 免疫老化 / T細胞 / 健常人 / CML / CLL / MDS / 年齢 / Eomesdermin / PD-1 / ヘルパーT細胞 / 人 / 慢性骨髄性白血病 / 急性骨髄性白血病 |
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| Outline of Final Research Achievements |
According to Minato and colleagues at Kyoto University, aging-related T cells that appeared in large amounts due to aging of the mouse and onset of blood cancer were reported. We examined healthy humans and patients with hematological cancers. In peripheral blood of healthy volunteers, scenescence associated T-cells showing the same surface traits as mice increased with age. This cell had poor proliferative capacity after T cell receptor stimulation for 72 hours. Interferon Γ was mainly produced, and transcription factors “Eomesdermin” were frequently observed in these scenescence associated T cells.
Among patients with hematological cancers, similar cells were observed. However, there was no dramatic increase like mice which were reported by Minato, and the frequency of expression varied among cases.
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