Where and how are mature platelets produced?
Project/Area Number |
25461458
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Iwate Medical University |
Principal Investigator |
Ishida Yoji 岩手医科大学, 医学部, 教授 (70151389)
|
Co-Investigator(Kenkyū-buntansha) |
KOWATA Syugo 岩手医科大学, 医学部内科学講座血液腫瘍内科分野, 教授 (30418884)
ITO Shigeki 岩手医科大学, 医学部腫瘍内科学科, 教授 (60316362)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | megakaryocyte / thrombocytopoiesis / proplatelet / thick protrusion / immature platelet / 血小板産生 / preplatelet / 血小板造血 / 巨核球 / 血小板前駆体 / 成熟血小板 |
Outline of Final Research Achievements |
How and where mature platelets are produced were investigated. Two evidences were obtained. The first, megakaryocytes in the bone marrow extended the proplatelets into the sinusoid and the proplatelet snapped, resulting in the immature platelets were released into the sinusoid in a steady state. The second, in the emergency state, in which a lot of platelets were demanded in thrombocytopenia, another immature platelets called "thick protrusion" were released into the sinusoid. These two types of immature platelets were converted into the mature platelets in the circulation.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Pharmacokinetics and pharmacodynamics of dasatinib in the chronic phase of newly diagnosed chronic myeloid leukemia2016
Author(s)
Ishida Y, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Ogawa K, Nagashima T, Sato S, Watanabe R, Yamamoto S, Hirose T, Saitou S, Yonezumi M, Kondo T, Kato Y, Mochizuki N, Ohno K, Kishino S, Kubo K, OyakeT, Ito S, Inter-Michinoku Dasatinib Study Group
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Journal Title
Eur J Clin Pharmacol
Volume: 72
Pages: 185-193
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A prospective analysis of clinical efficacy and safety in chronic myeloid leukemia-chronic phase patients with imatinib resistance or intolerance as evaluated using European LeukemiaNet 2013 criteria2015
Author(s)
Kazunori Murai, Tomoaki Akagi, Kenji Shimosegawa, Tomohiro Sugawara, Kenichi Ishizawa, Shigeki Ito, Keiko Murai, Mutsuhito Motegi, Hisayuki Yokoyama, Hideyoshi Noji, Katsushi Tajima, Jun Kimura, Takaaki Chou, Kazuei Ogawa, Hideo Harigae, Kohmei Kubo, Koji Oba, Junichi Sakamot, Yoji Ishida
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Journal Title
European Journal of Haematology
Volume: 95
Pages: 558-565
DOI
Related Report
Peer Reviewed
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[Journal Article] Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial2015
Author(s)
Imagawa, J. Tanaka, H. Okada, M. Nakamae, H. Hino, M. Murai, K. Ishida, Y. Kumagai, T. Sato, S. Ohashi, K. Sakamaki, H. Wakita, H. Uoshima, N. Nakagawa, Y. Minami, Y. Ogasawara, M. Takeoka, T. Akasaka, H. Utsumi, T. Uike, N. Sato, T. Ando, S. Usuki, K. Morita, S. Sakamoto, J. Kimura, S. Dadi Trial Group
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Journal Title
Lancet Haematol
Volume: 2
Pages: e528-35
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up2014
Author(s)
Fujisawa S, Nakamae H, Ogura M, Ishizawa K, Taniwaki M, Utsunomiya A, Matsue K, Takamatsu Y, Usuki K, Tanimoto M, Ishida Y, Akiyama H, Onishi S
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Journal Title
Int J Haematol
Volume: 99
Pages: 141-153
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of dasatinib versus imatinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia (CML-CP): Subset analysis of the DASISION trial with 2-year follow-up2013
Author(s)
Fujisawa, S. Nakamae, H. Ogura, M. Ishizawa, K. Taniwaki, M. Utsunomiya, A. Matsue, K. Takamatsu, Y. Usuki, K. Tanimoto, M. Ishida, Y. Akiyama, H. Onishi, S.
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Journal Title
Int J Hematol
Volume: 99
Pages: 1674-79
DOI
Related Report
Peer Reviewed
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[Journal Article] World’s first telepathology experiments employing ultra high speed Äb0internet satellite, nicknamed “KIZUNA”2013
Author(s)
Takashi Sawai, Miwa Uzuki, Yasuhiro Miura, Akihisa Kamataki, Tsubasa Matsumura, Kenji Saito, Akira Kurose, Yoshiyuki R. Osamura, Naoki Yoshimi, Hiroyuki Kanno, Takuya Moriya, Yoji Ishida, Yohichi Satoh, Masahiro Nakao, Emiko Ogawa, Satoshi Matsuo, Hiroyuki Kasai, Kazuhiro Kumagai, Toshihiro Motoda, Nathan Hopson
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Journal Title
J Pathol Inform
Volume: 4
Pages: 24
DOI
Related Report
Peer Reviewed
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[Presentation] Velocity of Early BCR-ABL Transcript Elimination As an Optimized Predictor of Deep Molecular Response in Chronic Myeloid Leukemia Patients in Chronic Phase on Treatment with Dasatinib2015
Author(s)
Kazunori Murai, Kohei Yamaguchi, Shigeki Ito, Tomoaki Akagi, Kazuei Ogawa, Inomata Mitsue, Kuniaki Meguro, Reiko Watanabe, Takuto Miyagishima, Kentaro Wakasa, Motohiro Shindo, Yasuhiko Tsukushi, Kohmei Kubo, Koji Oba, Junichi Sakamoto and Yoji Ishida,
Organizer
57th Annual Meeting of America Society of Hematology
Place of Presentation
Orland, FL, USA
Year and Date
2015-12-07
Related Report
Int'l Joint Research
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[Presentation] Recombinant Thrombomodulin for the Treatment of Transplantation-Associated Coagulopathy after Allogeneic Hematopoietic Stem Cell Transplantation: A Multi-Center Study in Japan2015
Author(s)
Kazuyoshi Ishii, Shosaku Nomura, Shinya Fujita, Atushi Satake, Tomoki Ito, Yuta Katayama, Taiichi Kyo, Shuichi Ota, Masanori Seki, Shigeru Chiba, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ikezoe, Hideo Yagi, Kunio Hayashi, Yoji Ishida, Naohito Fujishima, Kenichi Sawada, Masaya Okada, and Hiroyasu Ogawa,
Organizer
57th Annual Meeting of America Society of Hematology
Place of Presentation
Orland, FL, USA
Year and Date
2015-12-07
Related Report
Int'l Joint Research
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[Presentation] Platelet Progenitors after Leaving Bone Marrow2015
Author(s)
Shugo Kowata, Ryo Togawa, Yoshiaki Okano, Sumio Isogai, Jiro Hitomi, Kazunori Murai, Shigeki Ito, Yoji Ishida,
Organizer
57th Annual Meeting of America Society of Hematology
Place of Presentation
Orland, FL, USA
Year and Date
2015-12-06
Related Report
Int'l Joint Research
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[Presentation] Comparison of micafungin and liposome amphotericin B for empirical anti fungal therapy in febrile neutropenic patients with hematological malignancies: A randomized controlled study2015
Author(s)
Fujisawa Y, Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
Organizer
20th Congress of the European Hematology Association
Place of Presentation
Vienna, Austria
Year and Date
2015-06-11 – 2015-06-14
Related Report
Int'l Joint Research
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[Presentation] Doripenemu versus meropenem as the first-line mono-therapy in high risk febrile neutropenic patients with acute leukemia : A randomized, controlled study2015
Author(s)
Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fijishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
Organizer
20th Congress of the European Hematology Association
Place of Presentation
Vienna, Austria
Year and Date
2015-06-11 – 2015-06-14
Related Report
Int'l Joint Research
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[Presentation] COMPARISON OF MICAFUNGIN AND LIPOSOMAL AMPHOTERICIN B FOR EMPIRICAL ANTIFUNGAL THERAPY IN FEBRILE NEUTROPENIC PATIENTS WITH HEMATOLOGICAL MALIGNANCIES: A RANDOMIZED CONTROLLED TRIAL2015
Author(s)
Fujisawa Y, Tatsuo Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata1 S, Ito S, Ishida Y
Organizer
the 20th Congress of the European Hematology Association
Place of Presentation
Vienna, Austria
Year and Date
2015-06-11 – 2015-06-14
Related Report
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[Presentation] DORIPENEM VERSUS MEROPENEM AS THE FIRST-LINE MONO-THERAPY IN HIGH-RISK FEBRILE NEUTROPENIC PATIENTS WITH ACUTE LEUKEMIA: A RANDOMIZED, CONTROLLED TRIAL2015
Author(s)
Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
Organizer
the 20th Congress of the European Hematology Association
Place of Presentation
Vienna, Austria
Year and Date
2015-06-11 – 2015-06-14
Related Report
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[Presentation] Clinical Efficacy and Safety Of Dasatinib For Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase In Japa2013
Author(s)
Kohei Yamaguchi, Kazunori Murai, Shigeki Ito, Tomoaki Akagi, , Kazuei Ogawa, Kuniaki Meguro, Mitsue Inomata, Reiko Watanabe, Takuto Miyagishima, Kentaro Wakasa, Motohiro Shindo, Yasuhiko Tsukushi, Kohmei Kubo, and Yoji Ishida
Organizer
55th ASH annual Meeting and Exposition
Place of Presentation
New Orleans
Year and Date
20131208-20131211
Related Report
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[Presentation] The prospective analysis of clinical efficacy and adverse events in CML-CP patients with imatinib resistance or intolerance, evaluated by European LeukemicNet (ELN) 2013 criteria2013
Author(s)
Kazunori Murai, Tomoaki Akagi, Kenji Shimosegawa, Kenichi Ishizawa, Tomohiro Sugawara, Hisayuki Yokoyama, Hideyoshi Noji, Kazuei Ogawa, Katsushi Tajima, Koji Ooba, Junichi Sakamoto, Koumei Kubo, Hisashi Sakamaki, Hideo Harigae, and Yoji Ishida
Organizer
55th ASH annual Meeting and Exposition
Place of Presentation
New Orleans
Year and Date
20131208-20131211
Related Report
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[Presentation] Pharmacokinetic (PK) & Pharmacodynamic (PD) analysis of Dasatinib in Chronic Phase of Newly Diagnosed Chronic Myeloid Leukemia (CML-CP)2013
Author(s)
Ishida Y, Murai K, Yamaguchi K, Miyagishima T, Shindo M, Ogawa K, Nagashima T, Sato S, Watanabe R, Yamamoto S, Hirose T, Saitou S, Yonezumi M, Kondo K, Kato Y, Mochizuki N, Ohno K, Kishino S, Ito S, Kubo K and Inter-Michinoku Dasatinib Study Group(IMIDAS)
Organizer
55th ASH annual Meeting and Exposition
Place of Presentation
New Orleans
Year and Date
20131208-20131211
Related Report
-
[Presentation] Discontinuation of Dasatinib in Patients with CML Who Have Maintained Complete Molecular Response for at least One Year: Results From a Prospective Discontinuation (DADI) Trial2013
Author(s)
Tanaka H, Imagawa J, Okada M, Nakamae H, Hino M, Murai K,Ishida Y, Kumagai T, Sato S, Ohashi K, Sakamaki H, Wakita H, Uoshima N, Nakagawa Y, Minami Y, Ogasawara M, Takeoka T, Akasaka H, Morita S, Sakamoto J, and Kimura S, on behalf of the DADI Trial Group, JAPAN
Organizer
55th ASH annual Meeting and Exposition
Place of Presentation
New Orleans
Year and Date
20131208-20131211
Related Report
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