Development of novel therapeutic strategy for acute GVHD using IL-21 signal blockade
| Project/Area Number |
25461459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
oh iekuni 自治医科大学, 医学部, 講師 (20398514)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | IL-21 / ヒト化マウスGVHDモデル / HLA半合致移植 / Alemtuzumab / ATG / PT-CY / GVHD / リンパ球混合反応 / IFN-g / 遺伝子改変T細胞 / CRISPR/Cas9 / RGEN / 同種造血幹細胞移植 / 移植片対宿主病 / 移植片対白血病効果 / CD19キメラ抗原受容体 / Si-TCR |
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| Outline of Final Research Achievements |
Over the past several years, some studies have been made on relationship between GVHD and IL-21 by using experimental mouse GVHD model. From these animal studies, blocking the IL-21 signaling after bone marrow transplantation can attenuate GVHD without compromising the GVL effect. IL-21 signal blockade may be an ideal therapeutic target molecule to treat GVHD. Near future, when anti-human IL-21 neutralizing antibody that can be administered to human are developed, they can be used as antibody drugs like tocilizumab and infliximab already used for the treatment of rheumatoid arthritis.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] A low-dose cytarabine, aclarubicin and granulocyte colony-stimulating factor priming regimen versus a daunorubicin plus cytarabine regimen as induction therapy for older patients with acute myeloid leukemia: A propensity score analysis.2016
Author(s)
Minakata D, Fujiwara S, Ito S, Mashima K, Umino K, Nakano H, Kawasaki Y, Sugimoto M, Yamasaki R, Yamamoto C, Ashizawa M, Hatano K, Okazuka K, Sato K, Oh I, Ohmine K, Suzuki T, Muroi K, Kanda Y.
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Journal Title
Leuk Res.
Volume: 42
Pages: 82-87
Related Report
Peer Reviewed / Open Access
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