| Project/Area Number |
25461472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Wakayama Medical University (2015)
Kyoto University (2013-2014) |
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Principal Investigator |
FUJII Takao 和歌山県立医科大学, 医学部, 教授 (70255462)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Motomu 京都大学, 大学院医学研究科, 助教 (60512845)
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| Research Collaborator |
KONDO Seiko
ISHIGOOKA Nozomi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 全身性エリテマトーデス / 中枢神経障害 / 自己抗体 / サイトカイン / 抗核抗体 / 脳脊髄液 / ケモカイン / 中枢神経症状 |
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| Outline of Final Research Achievements |
In patients with systemic lupus erythematosus (SLE), neuropsychiatric manifestations (NPSLE) is a refractory disorder, because their disease-specific markers and treatment strategy are not well determined. The present study shows a certain subset of NPSLE, which has a link of cerebrospinal fluid (CSF)-autoantibodies, CSF-inflammatory mediators, and blood brain barrier (BBB) permeabilities. Especially, CSF-IL-6 concentration was elevated in association with anti-NR2 antibodies by BBB injury. Also, anti-U1RNP antibodies may activate IFN-α production intrathecally and up-regulate CSF-IL-6 in the presence of CSF-anti-NR2 antibodies. We can conclude that both anti-NR2 and U1RNP antibody detections in NPSLE may be useful not only for diagnosis, but also treatment decision in primary NPSLE patients.
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