Clinical and basic research for the overcoming of steroid induced osteoporosis

• Project/Area Number: 25461475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kobe University
• Principal Investigator: Kageyama Goichi 神戸大学, 医学(系)研究科(研究院), 研究員 (80631621)
• Co-Investigator(Kenkyū-buntansha): MORINOBU Akio 神戸大学, 大学院, 准教授 (10294216)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ステロイド性骨粗鬆症 / 脆弱性骨折 / 膠原病 / FRAX / ビスフォスフォネート製剤

Outline of Final Research Achievements

Clinical research) Incidence of fragility fracture of patients undergoing high dose glucocorticoid therapy at Kobe University Hospital were studied retrospectively. We found high-dose GC therapy caused the fragility fracture very frequently. And we found some risk factors associating with fragility fractures. The prospective study about high-dose GC therapy is currently undergoing.
Basic research) The effects on osteoclast differentiation of steroids, as well as various endogenous substances were carried out. We found some substances affect the differentiation of osteoclast.

Research Products

• [Journal Article] ステロイド大量療法下におけるビスホスホネート製剤の骨折予防効果と骨折リスクについて (2014)
  • Author(s): 蔭山豪一 森信暁雄
  • Journal Title: Osteoporosis Japan Volume: 22 Pages: 697-701
  • Acknowledgement Compliant
• [Presentation] Very High Frequency of Fragility Fractures Associated with High-Dose Glucocorticoids in Postmenopausal Women: A Retrospective Study (2015)
  • Author(s): Goichi Kageyama, Takaichi Okano, Yuzuru Yamamoto, Keisuku Nishimura, Daisuke Sugiyama, Jun Saegusa, Go Tsui, Shunichi Kumagai, Akio Morinobu1
  • Organizer: 2015 American College of Rheumatology Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] FRAX主要骨折確率9.3%以上の患者がステロイド大量療法を行うときには、ビスフォスフォネート剤の脆弱性骨折の予防効果は不十分である (2014)
  • Author(s): 蔭山豪一 他
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 9.3% (2014)
  • Author(s): G Kageyama et al
  • Organizer: アメリカ骨代謝学会
  • Place of Presentation: アメリカ ヒューストン
  • Year and Date: 2014-06-12 – 2014-06-16
• [Presentation] Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 9.3% (2014)
  • Author(s): G Kageyama et al
  • Organizer: ヨーロッパリウマチ学会
  • Place of Presentation: フランス パリ
  • Year and Date: 2014-06-10 – 2014-06-14
• [Presentation] Ineffective fracture prevention by bisphosphonate in patients undergoing high dose glucocorticoid therapy with a FRAX ten year probability greater than 5.8% (2014)
  • Author(s): Goichi Kageyama , Takaichi Okano, Yuzuru Yamamoto, Daisuke Sugiyama, Go Tsuji, Kousaku Tsuda, Soshi Takahashi, Miwa Nishida, Kengo Akashi, Keisuke Nishimura, Sho Sendo, Yoshinori Kogata, Jun Saegusa, Seiji Kawano, Shunichi Kumagai, Akio Morinobu
  • Organizer: Annual European Congress of Rheumatology EULAR 2014
  • Place of Presentation: パリ