Inflammatory cytokines and chemokines in an autoinflammatory disorder, Nakajo-Nishimura syndrome.
Project/Area Number |
25461478
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Nagasaki University |
Principal Investigator |
ARIMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
|
Co-Investigator(Kenkyū-buntansha) |
IDA Hiroaki 久留米大学, 医学部, 教授 (60363496)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 慢性炎症 / 炎症性疾患 / 炎症 / 慢性 / シグナル伝達 |
Outline of Final Research Achievements |
The ubiquitin-proteasome pathway is responsible for selective degradation of short-lived, misfolded and toxic proteins. It plays an important rule in transcriptional regulation. Nakajo-Nishimura syndrome (NNS) (MIM 256040) is an autosomal recessive autoinflammatory disorder characterized by periodic fever, partial lipodystrophy, contracture of joints, skin rash and calcification of basal ganglia. Homozygous mutation in the PSMB8 gene and decreased chymotrypsin-like activity indicated that dysfunction of the proteasome can result in the autoinflammatory condition. Genes were identified in cultured cells under the condition of proteasome inhibition. These findings suggest that decrease of proteasome activity is associated with an increased expression of inflammatory cytokines. The ubiquitin-proteasome pathway would play an important rule against inflammation. This may provide a new insight into the pathogenesis of other persistent inflammatory diseases.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.2016
Author(s)
Ichinose K, Arima K, Umeda M, Fukui S, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Sato S, Origuchi T, Kawakami A.
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Journal Title
Cytokine.
Volume: 79
Pages: 31-37
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.2016
Author(s)
Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A, Tsokos GC.
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Journal Title
Arthritis Rheumatol.
Volume: 68
Issue: 4
Pages: 944-952
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] RS3PE症候群2015
Author(s)
折口 智樹, 有馬 和彦, 川尻 真也, 古賀 智裕, 玉井 慎美, 中村 英樹, 川上 純, 塚田 敏昭, 宮下 賜一郎, 藤川 敬太, 溝上 明成, 岩永 希, 古山 雅子, 中島 宗敏, 河部 庸次郎, 荒牧 俊幸, 植木 幸孝, 福田 孝昭, 江口 勝美
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Journal Title
九州リウマチ
Volume: 35
Pages: 1-6
NAID
Related Report
Peer Reviewed
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[Journal Article] Association between hemoglobin A1c and carotid atherosclerosis in rural community-dwelling elderly Japanese men.2015
Author(s)
Shimizu Y, Nakazato M, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Hayashida N, Yamasaki H, Kusano Y, Takamura N, Aoyagi K, Maeda T.
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Journal Title
J Physiol Anthropol.
Volume: 34
Issue: 1
Pages: 16-17
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Risk factors of adverse events during treatment in elderly patients with rheumatoid arthritis: an observational study.2015
Author(s)
Iwanaga N, Arima K, Terada K, Ueki Y, Horai Y, Suzuki T, Nakashima Y, Kawashiri SY, Ichinose K, Tamai M, Nakamura H, Aoyagi K, Kawakami A, Origuchi T.
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Journal Title
Int J Rheum Dis.
Volume: 0
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.2015
Author(s)
Suzuki T, Iwamoto N, Yamasaki S, Nishino A, Nakashima Y, Horai Y, Kawashiri SY, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Miyamoto C, Osaki M, Ohyama K, Kuroda N, Kawakami A.
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Journal Title
J Rheumatol.
Volume: 0
Pages: 0-0
Related Report
Peer Reviewed
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[Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2014
Author(s)
chinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
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Journal Title
Clin Immunol.
Volume: 157
Issue: 2
Pages: 114-120
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki islands study.2014
Author(s)
Shimizu Y, Nakazato M, Sekita T, Kadota K, Miura Y, Arima K, Yamasaki H, Goto H, Takamura N, Aoyagi K, Maeda T
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Journal Title
Aging Male
Volume: 23
Issue: 2
Pages: 100-105
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Nishino A, Iwamoto N, Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
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Journal Title
Rheumatology (Oxford).
Volume: -
Issue: 8
Pages: 1452-1456
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between renal impairment and anemia in older, rural Japanese men: the Nagasaki Islands study.2014
Author(s)
Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Tamai M, Arima K, Yamasaki H, Kusano Y, Takamura N, Maeda T
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Journal Title
J Physiol Anthropol
Volume: 33
Issue: 1
Pages: 7-8
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki Islands study.2014
Author(s)
Shimizu Y, Nakazato M, Sekita T, Kadota K, Miura Y, Arima K, Yamasaki H, Goto H, Takamura N, Aoyagi K, Maeda T.
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Journal Title
Aging Male.
Volume: 23
Pages: 1-6
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis.2014
Author(s)
Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
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Journal Title
Annals of Rheumatic Diseases
Volume: 73
Issue: 12
Pages: 2219-20
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study.2014
Author(s)
Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Tamai M, Arima K, Yamasaki H, Kusano Y, Takamura N, Maeda T.
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Journal Title
J Physiol Anthropol.
Volume: 33
Pages: 7-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: the Nagasaki Islands Study2014
Author(s)
Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Tamai M, Kadota K, Arima K, Yamasaki H, Takamura N, Aoyagi K, Maeda T
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Journal Title
Atherosclerosis
Volume: 233
Issue: 2
Pages: 525-529
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.2014
Author(s)
Kawashiri SY, Suzuki T, Nakashima Y, Horai Y, Okada A, Iwamoto N, Ichinose K, Tamai M, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
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Journal Title
Rheumatology (Oxford).
Volume: 53
Issue: 3
Pages: 562-569
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Relationship between adult height and body weight and risk of carotid atherosclerosis assessed in terms of carotid intima-media thickness: The Nagasaki Islands study.2013
Author(s)
Shimizu Y, Nakazato M, Sekita T, Kadota K, Arima K, Yamasaki H, Goto H, Shirama S, Takamura N, Aoyagi K, Maeda T.
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Journal Title
J Physiol Anthropol
Volume: 32
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] An elderly patient with chronic active Epstein-Barr virus infection with mixed cryoglobulinemia and review of the literature.2012
Author(s)
Ichinose K, Origuchi T, Tashiro N, Kawashiri SY, Iwamoto N, Fujikawa K, Aramaki T, Arima K, Tamai M, Yamasaki S, Nakamura H, Moriuchi H, Kawakami A.
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Journal Title
Mod Rheumatol.
Volume: Aug.16
Issue: 5
Pages: 1022-1028
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach.2012
Author(s)
Kita J, Tamai M, Arima K, Kawashiri SY, Horai Y, Iwamoto N, Okada A, Koga T, Nakashima Y, Suzuki T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
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Journal Title
Mod Rheumatol
Volume: 23
Issue: 2
Pages: 254-259
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 自己炎症症候群の診断と治療2015
Author(s)
井田 弘明
Organizer
(第112回(2015年) 日本内科学会講演会
Place of Presentation
みやこめっせ(京都府・京都市)
Year and Date
2015-04-10
Related Report
Invited
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[Presentation] STRINGENT THERAPIES IMPROVE BOTH RADIOGRAPHIC AND CLINICAL OUTCOME IN EARLY-STAGE RA PATIENTS FROM JAPANESE POPULATION: LONGITUDINAL STUDY FROM NAGASAKI EARLY ARTHRITIS COHORT2013
Author(s)
M. Tamai, Y. Nakashima, T. Suzuki, J. Kita, A. Okada, S.-Y. Kawashiri, N. Iwamoto, K. Ichinose, K. Arima, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, K. Eguchi, A. Kawakami
Organizer
European League against rheumatism 2013
Place of Presentation
Madrid, Spain
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[Presentation] AUTOMATED BREAST VOLUME SCANNER (ABVS), A NEW AUTOMATED ULTRASONIC DEVICE, IS USEFUL TO EXAMINE JOINT INJURY IN PATIENTS WITH RHEUMATOID ARTHRITIS2013
Author(s)
S.-Y. Kawashiri, T. Suzuki, Y. Nakashima, Y. Horai, A. Okada, N. Iwamoto, K. Ichinose, M. Tamai, K. Arima, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, K. Eguchi, A. Kawakami
Organizer
European League against rheumatism 2013
Place of Presentation
Madrid, Spain
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[Presentation] THE SEVERITY OF SYNOVIAL INFLAMMATION ASSESSED BY MUSCULOSKELETAL ULTRASONOGRAPHY CORRELATES WITH THAT OF OSTEITIS ASSESSED BY MAGNETIC RESONANCE IMAGING IN PATIENTS WITH RHEUMATOID ARTHRITIS2013
Author(s)
S.-Y. Kawashiri, T. Suzuki, Y. Nakashima, Y. Horai, A. Okada, N. Iwamoto, K. Ichinose, K. Arima, M. Tamai, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, K. Eguchi, A. Kawakami
Organizer
European League against rheumatism 2013
Place of Presentation
Madrid, Spain
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[Presentation] THE SEVERITY OF SYNOVIAL INFLAMMATION ASSESSED BY MUSCULOSKELETAL ULTRASONOGRAPHY CORRELATES WITH THAT OF OSTEITIS ASSESSED BY MAGNETIC RESONANCE IMAGING IN PATIENTS WITH RHEUMATOID ARTHRITIS - Guided Poster Tours2013
Author(s)
S.-Y. Kawashiri, T. Suzuki, Y. Nakashima, Y. Horai, A. Okada, N. Iwamoto, K. Ichinose, K. Arima, M. Tamai, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, K. Eguchi, A. Kawakami
Organizer
European League against rheumatism 2013
Place of Presentation
Madrid, Spain
Related Report
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