The mechanism of dysregulation of inflammation in systemic lupus erythematosus

• Project/Area Number: 25461479
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Yokohama City University
• Principal Investigator: ASAMI Yukiko 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (40644464)
• Co-Investigator(Kenkyū-buntansha): YOSHIMI Ryusuke 横浜市立大学, 附属病院, 助教 (70585265) ; TAKENO Mitsuhiro 日本医科大学, 医学部, 准教授 (50236494) ; UEDA Atsuhisa 横浜市立大学, 医学部, 准教授 (60295483)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 免疫学 / 内科学 / 膠原病学

Outline of Final Research Achievements

The pathogenesis of systemic lupus erythematosus (SLE) or Sjogren's syndrome (SS) is still unknown. In this study, we investigated the role of autoantigen TRIM21 in SLE pathogenesis. The mRNA level of TRIM21 was higher in peripheral blood mononuclear cells from patients with SLE as compared to healthy controls (HC). TRIM21 mRNA levels correlated positively with SLE disease activity. Type I interferon (IFN) mRNA levels showed a negative correlation with TRIM21 mRNA levels in HC but not in patients with SLE. These results suggest that dysregulation of TRIM21 to function as an negative regulator for type I IFN expression is one of the cause of SLE pathogenesis. Thus TRIM21 may have potential as a therapeutic target for SLE.

Research Products

• [Presentation] 強皮症における抗SS-A抗体やリウマチ因子の臨床的意義． (2016)
  • Author(s): 神山玲光, 吉見竜介, 土田奈緒美, 杉山裕美子, 峯岸薫, 田村真麻, 桐野洋平, 上原武晃, 浅見由希子, 関口章子, 出口治子, 井畑淳, 大野滋, 川井孝子, 五十嵐俊久, 長岡章平, 石ヶ坪良明, 上田敦久
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-04-21
• [Presentation] 全身性エリテマトーデスにおける自己抗原TRIM21の役割． (2014)
  • Author(s): 神山玲光, 吉見竜介, 國下洋輔, 岸本大河, 峯岸薫, 浜真麻, 桐野洋平, 浅見由希子, 上田敦久, 岳野光洋, 石ヶ坪良明.
  • Organizer: 第58回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京港区）
  • Year and Date: 2014-04-24 – 2014-04-26
• [Presentation] 全身性エリテマトーデスにおける自己抗原TRIM21の役割 (2014)
  • Author(s): 神山玲光, 吉見竜介, 國下洋輔, 岸本大河, 峯岸薫, 浜真麻, 桐野洋平, 浅見由希子., 上田敦久, 岳野光洋, 石ヶ坪良明
  • Organizer: 第58回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京）