Genotype identification of RA and SLE using Fc gamma RIIB-deficient B6 mice.
| Project/Area Number |
25461486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSE Sachiko 順天堂大学, 医学部, 准教授 (00127127)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 全身性エリテマトーデス / 疾患モデルマウス / 遺伝子 / Fcレセプター / 関節リウマチ / モデルマウス / Yaa遺伝子 / FcγRIIB |
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| Outline of Final Research Achievements |
Background: FcγRIIB negatively regulates BCR-mediated activation signals. We used FcγRIIB-deficient B6-congenic mouse strain (KO1) spontaneously developed pathology of rheumatoid arthritis (RA). Methods: To analyse the phenotypic change of KO1 by crossing with lupus prone B6.Yaa and New Zealand White (NZW) mice, we established the KO1.Yaa mice,F1 and F2 hybrid of KO1 and NZW mice.Results: The KO1.Yaa mice and (KO1 x NZW)F1 mice did not develop the phenotype of RA, but developed lupus phenotype.In (KO1 x NZW) F2 mice, RA, SLE, and Sjogren syndrome developed independently or overlapped in an individual mouse. We found that the B6-derived locus located in the centromeric region on chromosome 12 was significantly associated with all these disease phenotypes, suggesting that this locus may play a role in common process shared by these diseases.Conclusion: Phenotypic specificity depends on the genetic factors sharing RA, SLE, and Sjogren syndrome.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus2015
Author(s)
Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y
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Journal Title
J Rheumatol
Volume: 42
Issue: 5
Pages: 826-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013
Author(s)
Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
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Journal Title
mice.
Volume: 43
Issue: 3
Pages: 770-778
DOI
Related Report
Peer Reviewed
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[Presentation] Disease flare-up patterns and predictors in a long-term follow-up of 423 Japanese SLE patients from the monocentric cohort JUDE study.2015
Author(s)
Hirofumi Amano, Seiichiro Ando, Kentaro Minowa, Takashi Watanabe, Michihiro Ogasawara, Shinji Morimoto, Yoshiaki Tokano, Ken Yamaji, Naoto Tamura, Yoshinari Takasaki.
Organizer
EULAR (Annual European Congress of Rheumatology)
Place of Presentation
Rome, Italy
Year and Date
2015-06-10
Related Report
Int'l Joint Research
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[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice2014
Author(s)
Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Norihiro Tada, Hiroyuki Nishimura, Toshiyuki Takai, Shirai Toshikazu, Sachiko Hirose, Yoshinari Takasaki
Organizer
日本リウマチ学会総会・学術集会
Place of Presentation
東京
Related Report
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