Establishment of an immune regulation of T cell function through gut microbiota modulation
| Project/Area Number |
25461488
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
Shimizu Jun 聖マリアンナ医科大学, 医学部, 准教授 (30509964)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Takai Kenji 聖マリアンナ医科大学, 医学部, (客員)教授 (60121167)
Fujiwara Naruyoshi 聖マリアンナ医科大学, 医学部, 助教 (50365425)
Arimitsu Nagisa 聖マリアンナ医科大学, 医学部, 助教 (40408688)
Takada Erika 聖マリアンナ医科大学, 医学部, 研究技術員 (90398959)
Hirotsu Chieko 聖マリアンナ医科大学, 医学部, 研究技術員 (90647174)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 腸内細菌叢メタゲノミクス / T細胞 / ベーチェット病 / Tリンパ球 / 腸内細菌メタゲノミクス / Th17細胞 / 炎症性腸疾患 / 再発性多発軟骨炎 / 全身性エリテマトーデス |
|---|
| Outline of Final Research Achievements |
We have reported that T cell differentiation was skewed in the peripheral blood of patients with Behcet’s disease (BD). We hypothesized that gut microbiota of BD patients involved in the skewed T cell differentiation from a review of the literature. We conducted metagenomic analysis of microbiota using next generation sequencer. We showed that the phylum Actinobacteria and the genus Bifidobacterium were prevalent in BD patients with statistical significance. The order Clostridia and the genus Megamonas were prevalent in normal individuals with statistical significance. Bacterial diversity of each sample was comparable in BD patients and normal individuals and the two group’s plots of PcoA had a significant distance as beta diversity. These data suggest that the compositional changes of gut microbes may be one type of dysbiosis (unfavorable microbiota alteration) in patients with BD. The dysbiosis may have an association with the pathophysiology of BD.
|
Report
(4 results)
Research Products
(15 results)
-
-
-
-
-
-
[Journal Article] Pax7 Gene Induction Rapidly Regulates Myocyte Homeostasis in Human Induced Pluripotent Stem (iPS) Cells.2014
Author(s)
Misawa H, Saito A, Shimizu J, Iinuma M, Shiratsuchi T, Fujiwara N, Takai K, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Beppu M, Suzuki N.
-
Journal Title
St. Marianna Medical Journal.
Volume: 5
Pages: 59-67
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.2014
Author(s)
Sato T, Yamano Y, Tomaru U, Shimizu Y, Ando H, Okazaki T, Nagafuchi H, Shimizu J, Ozaki S, Miyazawa T, Yudoh K, Oka H, Suzuki N.
-
Journal Title
Mod Rheumatol
Volume: 24(1)
Issue: 1
Pages: 129-136
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells.2013
Author(s)
Fujiwara N, Shimizu J, Takai K, Arimitsu N, Saito A, Kono T, Umehara T, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.
-
Journal Title
Neurosci Lett.
Volume: 13
Pages: 947-6
DOI
Related Report
Peer Reviewed
-
[Journal Article] Transplantation of Motor Neurons Derived from Human iPS Cells into Total Transection Model of Spinal Cord Injury in Mice.2013
Author(s)
Umehara T, Arimitsu N, Iinuma M, Shimizu J, Takai K, Fujiwara N, Saito A, Kono T, Ueda Y, Wakisaka S, Suzuki T, Beppu M, Suzuki N.
-
Journal Title
St. Marianna Medical J
Volume: 4
Pages: 21-30
NAID
Related Report
Peer Reviewed
-
[Journal Article] Human iPS Cell Derived Neurons with Cortical Motor Neuron Phenotype are Relevant for Functional Recovery of Hemiplegic Mice with Injured Motor Cortex.2013
Author(s)
T, Arimitsu N, Shimizu J, Takai K, Fujiwara N, Umehara T, Saito A, Ueda Y, Wakisaka S, Suzuki T, Hashimoto T, Tanaka Y, Suzuki N.
-
Journal Title
St. Marianna Medical J
Volume: 4
Pages: 31-40
NAID
Related Report
Peer Reviewed
-
[Journal Article] IGFII/Akt Signaling Regulates Myocyte Homeostasis in Human Induced Pluripotent Stem (iPS) Cells.2013
Author(s)
Saito A, Shimizu J, Fujiwara N, Takai K, Arimitsu N, Umehara T, Kono T, Misawa H, Ueda Y, Wakisaka S, Suzuki T, Beppu M, Suzuki N.
-
Journal Title
St. Marianna Medical J
Volume: 4
Pages: 41-48
NAID
Related Report
Peer Reviewed
-
-
