IgG4-related disease can cause MALT lymphoma
| Project/Area Number |
25461496
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Collagenous pathology/Allergology
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
Takizawa Jun 新潟大学, 医歯学系, 准教授 (70463990)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
尾山 徳秀 新潟大学, 医歯学総合病院, 特任准教授 (10600489)
曽根 博仁 新潟大学, 医歯学系, 教授 (30312846)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | MALTリンパ腫 / IgG4関連疾患 / 眼窩MALTリンパ腫 / 肺MALTリンパ腫 / リンパ形質細胞性リンパ腫 / MYD88変異 / MALT1遺伝子 / MATリンパ腫 / MYD88遺伝子 / 原発性マクログロブリン血症 |
|---|
| Outline of Final Research Achievements |
Recently some cases with MALT lymphoma arising from IgG4-related disease (IgG4-RD) were reported. To assess the association between MALT lymphoma and IgG4-RD, 69 patients with MALT lymphoma diagnosed in our hospital were examined. Of the 69 cases of MALT lymphoma, 11 (16 %) had IgG4-related disease by comprehensive diagnostic criteria for IgG4-RD. Orbita was the most frequently involved site (10 cases), followed by lung (one case). Three cases with orbital MALT lymphoma associated with IgG4-RD occurred second lymphoid neoplasms with different sites and clones, suggesting chronic inflammation produced by IgG4-RD can promote the development of lymphoid malignancies such as MALT lymphoma.
|
Report
(5 results)
Research Products
(6 results)
