Exploring the inflammation-autoimmune-fibrosis interaction by using novel mouse model for fibrosis and scleroderma
| Project/Area Number |
25461497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kyoto University |
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Principal Investigator |
Ashida Noboru 京都大学, 医学(系)研究科(研究院), 講師 (00538978)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 線維化 / 炎症 / 強皮症 / 自己免疫 |
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| Outline of Final Research Achievements |
To explore the role of NFκB in fibrosis, we made mice with deletion of IKKβ, an essential kinase for the activation of NFκB, in myofibroblasts. The mice presented massive fibrosis in skin and internal organs more in females, and autoantibodies were detected in serum. We submitted world patent application claiming this mouse as a novel animal model for fibrosis and scleroderma. We tried to unveil the mechanism of this phenotype, and found that kinase-independent function of IKKβ is responsible for the phenotypes, and identified AMAP1 as a binding protein with IKKβ.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.2014
Author(s)
Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M. and Ashida, N.
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Journal Title
Sci Rep.
Volume: 4
Issue: 1
Pages: 5094-5094
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Roles of IKKβ in fibrosis2014
Author(s)
Dat Nguyen-Tien, Masako Kishihata, Megumi Nishio, Kaeko Kamei, Kenji Kabashima, Yoshiki Miyachi, Masayuki Yokode, Takeshi Kimura, Noboru Ashida
Organizer
第37回日本分子生物学会年会
Place of Presentation
横浜
Year and Date
2014-11-25
Related Report
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[Presentation] The roles of NFχB in Fibrosis and Systemic Sclerosis2014
Author(s)
Dat Nguyen Tien, Satoshi Nakamizo, Akihiko Kitoh, Kaeko Kamei, Kenji Kabashima, Yoshiki Miyachi, Atsushi Utani, Hidenori Arai, Takeshi Kimura, Masayuki Yokode, Noboru Ashida
Organizer
第46回日本結合組織学会・第61回マトリックス研究会合同学術集会
Place of Presentation
名古屋
Year and Date
2014-06-05
Related Report
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