| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To explore the role of NFκB in fibrosis, we made mice with deletion of IKKβ, an essential kinase for the activation of NFκB, in myofibroblasts. The mice presented massive fibrosis in skin and internal organs more in females, and autoantibodies were detected in serum. We submitted world patent application claiming this mouse as a novel animal model for fibrosis and scleroderma. We tried to unveil the mechanism of this phenotype, and found that kinase-independent function of IKKβ is responsible for the phenotypes, and identified AMAP1 as a binding protein with IKKβ.
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