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Metabolomics-based molecular phenotyping of severe asthma

Research Project

Project/Area Number 25461504
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionTokai University

Principal Investigator

ASANO Koichiro  東海大学, 医学部, 教授 (60192944)

Co-Investigator(Kenkyū-buntansha) ABE Tadashi  東海大学, 医学部内科学系呼吸器内科学, 教授 (80129311)
Co-Investigator(Renkei-kenkyūsha) FUKUNAGA Koichi  慶應義塾大学, 医学部呼吸器内科, 講師 (60327517)
NAGAOKA Takashi  早稲田大学, 理工学術院, 講師 (00367054)
ARITA Makoto  東京大学, 薬学研究科, 准教授 (80292952)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords重症喘息 / バイオマーカー / メタボロミクス / 呼気ガス分析 / 揮発性有機化合物 / 喘息
Outline of Final Research Achievements

Cluster analyses using clinical parameters have identified several phenotypes of severe asthma, including early-onset allergic phenotype and later-onset eosinophilic phenotype. In the present study, we aimed to clarify molecular phenotypes of severe asthma using motabolomic approach.
We have identified that the levels of volatile organic compounds including benzene, xylene, and nonan in exhaled air of the patients with severe asthma were increased. In addition, serum levels of periostin were increased in a subpopulation of patients with severe asthma, who exhibited later-onset, non-atopic eosinophilic disease often accompanied with eosinophilic rhinosinusitis with nasal polyps. In conclusion, we were able to identify several non-invasive biomarkers that reflect either the severity or the phenotype of asthma.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] 気管支喘息とバイオマーカー2016

    • Author(s)
      松坂雅子、浅野浩一郎
    • Journal Title

      Annual Review 2016 呼吸器

      Volume: 無 Pages: 92-97

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phenotype of asthma related with high serum periostin levels2015

    • Author(s)
      Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 2 Pages: 175-180

    • DOI

      10.1016/j.alit.2014.07.003

    • NAID

      130005290305

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double Cold Trap Method to Determine the Concentrations of Volatile Organic Compounds in Human Expired Gas2015

    • Author(s)
      T. Nagaoka, N. Kobayashi, M. Kurahashi, T. Oguma, T. Aoki, T. Urano, C. Tsuji, K. Asano, T. Abe, K. Magatani, S. Takeda
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 4 Issue: 0 Pages: 112-118

    • DOI

      10.14326/abe.4.112

    • NAID

      130005084357

    • ISSN
      2187-5219
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Double cold-trap method to determine the concentrations of volatile organic compounds in human expired gas2015

    • Author(s)
      T. Nagaoka, N. Kobayashi, M. Kurahashi, T. Oguma, T. Aoki, T. Urano, C. Tsuji, K. Asano, T. Abe, K. Magatani, S. Takeda.
    • Journal Title

      Adv Biomed Eng

      Volume: 未確定

    • NAID

      130005084357

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exhaled nitric oxide measurement may predict asthma exacerbation after stepping down formoterol/budesonide combination therapy in adult asthma2014

    • Author(s)
      T. Shirai, T. Kawayama, H. Nagase, H. Inoue, S. Sato, K. Asano, H. Kume
    • Journal Title

      J Allergy Ther

      Volume: 5 Pages: 173-173

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis.2014

    • Author(s)
      Ueda T, Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, Obata T, Asano K, Betsuyaku T, Takeda J.
    • Journal Title

      Crit Care Med

      Volume: 42 Issue: 4 Pages: 288-295

    • DOI

      10.1097/ccm.0000000000000162

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Critical role of p38 and GATA3 in natural helper cell function.2013

    • Author(s)
      Kabata H, Moro K, Fukunaga K, Suzuki Y, Miyata J, Masaki K, Betsuyaku T, Koyasu S, Asano K.
    • Journal Title

      Nat Commun.

      Volume: 4 Issue: 1 Pages: 2675-2675

    • DOI

      10.1038/ncomms3675

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus2013

    • Author(s)
      Hata T, Nishimoto S, Nagao K, Takahashi H, Yoshida K, Ohyama M, Yamada T, Asano K, Amagai M
    • Journal Title

      J Immunol

      Volume: 191(1) Issue: 1 Pages: 83-90

    • DOI

      10.4049/jimmunol.1203536

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between serum periostin levels and severity/phenotype of asthma

    • Author(s)
      16. H Kabata, M Matsusaka, K Fukunaga, Y Suzuki, J Miyata, K Tanaka, K Masaki, T Mochimaru, S Ohta, K Izuhara, K Asano, T Betsuyaku
    • Organizer
      ATS2013 American Thoracic Society International Conference
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Phenotypes of asthma/COPD and exacerbation

    • Author(s)
      K Asano
    • Organizer
      18th Congress of the Asia Pacific Society of Respirology
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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